Synthesis And Characterisation Of Some Novel 5-Chloro Benzimidazole-2-One Derivatives With Specific Docking Studies Against PPAR-γ

Pharmaceutical Science-Pharmaceutical Chemistry for Novel drug discovery

Abstract

It is necessary to discover antidiabetic agents since diabetes is one of the most rapidly growing disorders . It is estimated by WHO that more than 420 million people are suffering from diabetes worldwide. It is very important to synthesize novel molecules for the treatment of diabetes. One of recent and very effective targets is Peroxisome Proliferator Activated Receptor γ (PPAR- γ) . In our current study, we have followed standard methods for the synthesis of   novel molecules and docking. A series of 5-chloro-1-(piperidin-4-yl)-1H-benzo[d]imidazole-2(3H)-one derivatives have been synthesized and characterized  by  various  spectroscopic  techniques  including  FT-IR,  Mass  and 1H NMR. All the synthesized  molecules  were analysed by suitable spectral methods i.e. FT-IR, Mass and 1H NMR. The compounds were docked against PPAR-γ by using MCULE software.  It was found that the synthesized molecules were active against PPAR-γ by their comparative docking scores with that of standard marketed drugs i.e. Rosiglitazone and Pioglitazone. In particular DSR-16, DSR-8 and  DSR-5 are showing more binding capacity. The synthesized molecules were identified to have good binding capacity with PPAR- γ according to their docking data.