https://www.ijlpr.com/index.php/journal <p data-start="131" data-end="696"><strong>Welcome to the IJLPR</strong></p> <p data-start="131" data-end="696">International Journal of Life Science and Pharma Research (IJLPR) [Online ISSN: 2250-0480] is a peer-reviewed international journal, published quarterly in English. IJLPR aims to disseminate high-quality review and research articles in the rapidly evolving fields of pharmaceutical and life sciences. As an open-access online journal, it ensures unrestricted access to all published content. Manuscripts submitted to the journal undergo an initial assessment by the editorial team and are subsequently reviewed by qualified peer reviewers, with additional expert evaluation as needed.</p> <p data-start="131" data-end="696"> </p> Lapin Press Publications [LPP] en-US International Journal of Life Science and Pharma Research 2250-0480 https://www.ijlpr.com/index.php/journal/article/view/2053 <p>Diabetic foot ulcers (DFUs) are one of the most serious consequences of diabetes mellitus, contributing significantly to infection, hospitalization, lower-limb amputation, decreased quality of life, and healthcare expenses. The burden of DFUs in India and the US between 2020 and 2025 is compared in this review, with an emphasis on prevalence, incidence, risk factors, clinical features, sequelae, and economic effects. The prevalence of DFUs is estimated to be around 6.3% worldwide, with the United States reporting a greater frequency (around 13%) than the pooled estimate for India (6.2%). India's vast population of diabetics results in a significant absolute burden, with significant regional and healthcare setting variations, notwithstanding the country's reported lower frequency. While neuro-ischemic ulcers are more commonly described in Western populations, DFUs in India are primarily neuropathic. Longer duration of diabetes, peripheral neuropathy, peripheral vascular disease, advanced age, male sex, infection, and poor foot care are important risk factors. In both countries, DFUs often lead to amputation, delayed recovery, recurrence, and substantial financial burden. However, direct comparisons are limited by variations in demographic characteristics, study methodologies, diagnostic techniques, and healthcare availability. Early screening, patient education, appropriate foot care, pressure offloading, infection control, vascular evaluation, and multidisciplinary care are all necessary for effective prevention.To produce accurate estimates and improve DFU prevention and clinical outcomes in India and the US, community-based surveillance must be strengthened and prospective studies must be carried out.</p> Pranathi Kurapati Devi Vara Prasad Rajulapati Tabitha R J Chandrika P Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0 2026-10-01 2026-10-01 8 19 10.22376/ijlpr.v16i3.2053 https://www.ijlpr.com/index.php/journal/article/view/2052 <p>Modified nucleoside analogues are re-emerging as candidate antibacterial scaffolds, but their systemic redox cost under inflammation and the value of a dietary antioxidant co-treatment are poorly quantified. Eighty-five male Wistar rats were randomised into 17 groups (n = 5): naive control, LPS-only, LPS + quercetin, and seven analogues (2FaraA, 6ClAraPur, araCMP, TTU, FluMP, araC, cCMP) each with and without quercetin on a uniform LPS background. Six hepatic oxidative markers and eleven haematological markers were measured and compressed using the Integrated Biomarker Response (IBR), an Oxidative Stress Index (OSI), principal-component analysis (PCA) and ROC analysis. The analogues imposed a reproducible, rank-ordered oxidative burden: araC (IBR = 21.57) &gt;cCMP (18.57) &gt; 2FaraA (16.34) &gt;FluMP (13.38) &gt; TTU (12.74) &gt; 6ClAraPur (11.43) &gt;araCMP (11.30), all above LPS-only (7.70) and control (0.40). OSI mirrored IBR (Pearson r = 0.983). Quercetin restored the IBR toward control in every analogue, by 64.9–84.3 % (mean 74.4 %), with the largest rescue for araC, the most pro-oxidant member. PC₁ captured 80.2 % of variance, ordering the groups along a single oxidative-burden axis. The antioxidant enzymes GPX, GSH and SOD (directed AUC 0.81–0.86) were most sensitive to quercetin, whereas serum AST was not (Kruskal–Wallis p = 0.73), indicating a redox-specific rather than a generalised hepatoprotective effect. These results establish a compact, integrative safety-screening framework that ranks modified nucleosides by systemic oxidative liability and demonstrates a consistent, class-independent quercetin redox rescue of approximately 74 %, offering a quantitative read-out for nucleoside-based antibacterial development.</p> ArshedAbd Ali Shihad Aliaksei G Sysa Copyright (c) 2026 https://creativecommons.org/licenses/by-nc-nd/4.0 2026-09-30 2026-09-30 1 7 10.22376/ijlpr.v16i3.2052