IN VIVO AND IN VITRO APPROACHES TO STUDY ALZHEIMER’S DISEASE

Pharmaceutical Science-Biotechnology

Authors

  • BIPASHA BARUA University School of Biotechnology, GGS Indraprastha university, Dwarka, Sector 16C, New Delhi
  • SURESH KUMAR University School of Biotechnology, GGS Indraprastha university, Dwarka, Sector 16C, New Delhi

Keywords:

Alzheimer’s disease, amyloid β, neurofibrillar tangles, gamma secretase, cholinesterase enzymes, acetylcholine receptors, GABA

Abstract

Alzheimer’s disease (AD) is a neurodegenerative disorder mainly causes cognitive impairments like deterioration in learning, reading, memory and cognition. The pathological hallmark associated with AD is the accumulation of amyloid beta (Aβ) peptides in the brain of the patients. The Aβ aggregation leads to plaque formation which is the main cause of neurodegeneration. The other characteristic which leads to AD involves cholinergic deficits and synaptic loss. In this review, the various in vivo and in vitro approaches are discussed to understand the pathophysiology of AD.

 

Published

2022-06-17

How to Cite

BIPASHA BARUA, & SURESH KUMAR. (2022). IN VIVO AND IN VITRO APPROACHES TO STUDY ALZHEIMER’S DISEASE: Pharmaceutical Science-Biotechnology. International Journal of Life Science and Pharma Research, 5(4), 9–20. Retrieved from https://www.ijlpr.com/index.php/journal/article/view/421

Issue

Volume 5 Issue 4, October - December 2015

Section

Review Articles
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