EFFECT OF METHYL METHANE SULFONATE ON EHRLICH ASCITES CARCINOMA CELLS: DOSE EFFECT RELATIONSHIPS

Life Science-cytology

Authors

  • P. VISHWAPRAKASH MAHADIMANE Department of Studies in Bioscience, University of Mysore, PG. Center, Hemagangothri, Hassan-573220, Karnataka, India.
  • V. VASUDEV Department of Studies in Bioscience, University of Mysore, PG. Center, Hemagangothri, Hassan-573220, Karnataka, India.

Keywords:

Ehrlich ascites carcinoma cells, Methyl methanesulfonate, Chromosomal aberrations, Dose effect relationships

Abstract

A well known monofunctional alkylating agent, Methyl methanesulfonate (MMS) has been employed to understand its influence on the chromosomes of Ehrlich ascites carcinoma (EAC) cells. The literature review revealed that there are no reports on this aspect. Hence, a dose range of 25 to 150mg/kg bw MMS were used and ascitic fluid was drawn from treated animals to analyze the chromosomal aberrations. The analysis of chromosomal aberrations revealed that there is significant increase in frequency of aberrations compared to controls. Further there was also a linear increase of aberrations as dose increased indicating the dose effect relationship. The results are discussed to highlight the exploitation of EAC model for clastogenicity in general and carcinogenesis in particular.

Published

2013-06-30

How to Cite

MAHADIMANE, P. V., & V. VASUDEV. (2013). EFFECT OF METHYL METHANE SULFONATE ON EHRLICH ASCITES CARCINOMA CELLS: DOSE EFFECT RELATIONSHIPS : Life Science-cytology. International Journal of Life Science and Pharma Research, 3(2), L22-L31. Retrieved from https://www.ijlpr.com/index.php/journal/article/view/337

Issue

Volume 3 Issue 2, April - June 2013

Section

Research Articles

Copyright (c) 2022 P. VISHWAPRAKASH MAHADIMANE, V. VASUDEV

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.