OVERPRODUCTION STRATEGIES FOR MICROBIAL SECONDARY METABOLITES: A REVIEW

Life Science-Molecular Biology

Authors

  • NAFISEH DAVATI Ph.D Student of Food Microbiology, Department of Food Science & Technology, Ferdowsi University of Mashhad, Mashhad, Iran
  • MOHAMMAD. B HABIBI NAJAFI Professor, Department of Food Science & Technology, Faculty of Agriculture, Ferdowsi University of Mashhad, P. O. Box 91775-1163, Mashhad, Iran

Keywords:

Secondary metabolites, Overproduction, Microbial, Strategies Genetic

Abstract

The formation of secondary metabolites is regulated by nutrients, growth rate, feedback control, enzyme inactivation, and enzyme induction. Regulation is influenced by unique low molecular mass compounds, transfer RNA, sigma factors and gene products formed during post-exponential development. The synthases of secondary metabolism are often coded by clustered genes on chromosomal DNA and infrequently on plasmid DNA. Strategies for overproduction of microbial products can be based on microbial response (Elicitors, quorum sensing), genetic engineering, metabolic engineering and ribosome engineering. Also molecular genetic improvement methods include amplification of SM biosynthetic genes, inactivation of competing pathways, disruption or amplification of regulatory genes, manipulation of secretory mechanisms, expression of a convenient heterologous protein, combinatorial biosynthesis.

Published

2013-03-31

How to Cite

DAVATI, N., & B HABIBI NAJAFI, M. (2013). OVERPRODUCTION STRATEGIES FOR MICROBIAL SECONDARY METABOLITES: A REVIEW: Life Science-Molecular Biology. International Journal of Life Science and Pharma Research, 3(1), L23-L37. Retrieved from https://www.ijlpr.com/index.php/journal/article/view/309

Issue

Volume 3 Issue 1, January - March 2013

Section

Review Articles

Copyright (c) 2022 NAFISEH DAVATI, MOHAMMAD. B HABIBI NAJAFI

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.