PARAOXONASE ACTIVITY AND PON1 (Q/R192) GENE POLYMORPHISM IN ISCHEMIC STROKE PATIENTS

Life Science-Genetics

Authors

  • MAGESH MUGUNDAN MURUGAN Research Scholar, Institute of Biochemistry, Madras Medical College, Chennai 600003, India
  • RENUKA ALAGIRISAMY Professor and Head, Department of Biochemistry, Sri Muthukumaran Medical College Hospital &Research Institute, Chennai 600069, India
  • SHARMILA MANOKARAN Research Scholar, Institute of Biochemistry, Madras Medical College, Chennai 600003, India
  • ANANDAN BALAKRISHNAN Department of Genetics, ALMPGIBMS, University of Madras, Taramani, Chennai 600113, India

Keywords:

Paraoxonase, allele, ischemic stroke, polymorphism

Abstract

Background: Paraoxonase (PON1) has two polymorphisms Q/R192 and L/M 55 associated with ischemic stroke. The effect of Q/R192 PON1 variants, its activity, and lipid profile in ischemic stroke were studied in South Indians. Design and Methods: The PON1-Q192R polymorphism, serum PON1-ARE activity and lipid profile were analyzed in 308 ischemic stroke patients and in 330 age and sex matched controls. Results: R allele frequency of the codon 192 polymorphism was higher in ischemic stroke cases when compared with controls. Odds ratio of the cases with RR + QR genotype versus QQ genotype was 1.67 (P < 0.01). Patients with ischemic stroke cases with QQ, QR, RR genotypes had highly significant LDL (P < 0.01) and HDL cholesterol (P < 0.01). Conclusion: Our data suggested that there was a significant association between PON1 activity, and PON1-Q192R genotypes in ischemic stroke in South Indians.

Published

2012-12-31

How to Cite

MUGUNDAN MURUGAN, M., ALAGIRISAMY, R., MANOKARAN, S., & BALAKRISHNAN, A. (2012). PARAOXONASE ACTIVITY AND PON1 (Q/R192) GENE POLYMORPHISM IN ISCHEMIC STROKE PATIENTS: Life Science-Genetics. International Journal of Life Science and Pharma Research, 2(4), L169-L176. Retrieved from https://www.ijlpr.com/index.php/journal/article/view/282

Issue

Volume 2 Issue 4, October - December 2012

Section

Research Articles

Copyright (c) 2022 MAGESH MUGUNDAN MURUGAN, RENUKA ALAGIRISAMY, SHARMILA MANOKARAN, ANANDAN BALAKRISHNAN

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.