Ameliorative Effect of Lagenaria siceraria on Cisplatin-Induced Kidney Injury in Wistar Rats
Keywords:
Lagenaria siceraria, Nephroprotective activity, Cisplatin, Hydro-alcoholic extractAbstract
The objective of the present study was conducted to investigate the nephroprotective activity of hydroalcoholic extract of Lagenaria siceraria against cisplatin-induced nephrotoxicity in Albino Wistar rats. Cisplatin (6mg/kg.bw.t, i.p.) used as nephrotoxicant. The oral administration of hydroalcoholic extract at two different doses (200mg/kg.bw.t and 400mg/kgb.w.t) of Lagenaria siceraria were used to examine the Nephroprotection using Urinary and serum biomarkers, as well as renal oxidative stress biomarkers, histological and immunohistological studies. Enhanced levels of Urinary, serum biomarkers, total protein and lipid peroxidation and decreased urinary creatinine and anti-oxidant enzymes observed after cisplatin induction. Treatment with Hydroalcoholic extract alters the Cisplatin induced nephrotoxic effects. Histopathological studies and immunohistochemical observations provided evidence consistent with the biochemical findings. Thus, the current study reveals the advantageous use of Lagenaria siceraria in renal toxicity.
References
Amina Džidić-Krivić, Emina K. Sher, Jasna Kusturica, Esma K. Farhat, Asma Nawaz, Farooq Sher, unveiling drug induced nephrotoxicity using novel biomarkers and cutting-edge preventive strategies, Chemico-Biological Interactions,Volume 388,2024, 110838.
Thiruchenthooran, V., Sánchez-López, E., & Gliszczyńska, A. (2023). Perspectives of the Application of Non-Steroidal Anti-Inflammatory Drugs in Cancer Therapy: Attempts to Overcome Their Unfavorable Side Effects. Cancers, 15(2), 475.
Ranmali Ranasinghe, Michael L. Mathai, Anthony Zulli, Cisplatin for cancer therapy and overcoming chemoresistance, Heliyon, Volume 8, Issue 9, 2022, e10608.
Piko N, Bevc S, Hojs R, Ekart R. The Role of Oxidative Stress in Kidney Injury. Antioxidants (Basel). 2023 Sep 16;12(9):1772.
Zhang J, Ye ZW, Tew KD, Townsend DM. Cisplatin chemotherapy and renal function. Adv Cancer Res. 2021; 152:305-327.
Tamargo, C., Hanouneh, M., & Cervantes, C. E. (2024). Treatment of Acute Kidney Injury: A Review of Current Approaches and Emerging Innovations. Journal of Clinical Medicine, 13(9), 2455.
Balkrishna A, Sharma N, Srivastava D, Kukreti A, Srivastava S, Arya V. Exploring the Safety, Efficacy, and Bioactivity of Herbal Medicines: Bridging Traditional Wisdom and Modern Science in Healthcare. Future Integr Med. 2024;3(1):35-49.
akshmi, S. & Thimmapuram, Usha & Rani, K.S (2012). A review on medicinal plants for nephroprotective activity. Asian Journal of Pharmaceutical and Clinical Research. 5. 8-14.
Mitali Bhutani, Supriya Singh Gaur, Rafeeya Shams, Kshirod Kumar Dash, Sustainable utilization of bottle gourd by-products: A nutritional and functional perspective,Food Chemistry Advances, Volume 8,2025,101073.
Begum Nabila, Khan Qudrat Ullah, Liu Leyna G., Li Wenwen, Liu Dahai, Haq Ijaz Ul Nutritional composition, health benefits and bio-active compounds of chickpea Frontiers in Nutrition Volume 10 - 2023
R.V, Desai & A.K, Seth & B.N, Shah. (2010). Phytopharmacological Profile of Lagenaria siceraria: A Review. Asian Journal of Plant Sciences. 9. 10.3923/ajps.2010.152.157.
Hasin Hasnat, Suriya Akter Shompa, Md. Mirazul Islam, Safaet Alam, Fahmida Tasnim Richi, Nazim Uddin Emon, Sania Ashrafi, Nazim Uddin Ahmed, Md. Nafees Rahman Chowdhury, Nour Fatema, Md. Sakhawat Hossain, Avoy Ghosh, Firoj Ahmed, Flavonoids: A treasure house of prospective pharmacological potentials, Heliyon, Volume 10, Issue 6,2024, e27533.
Sinan Saral, Eda Dokumacioglu, Tolga Mercantepe, Mehtap Atak, Seda Cinar, Ozlem Saral, Lamiye Yildiz, Hatice Iskender, Levent Tumkaya, The effect of white tea on serum TNF-α/NF-κB and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats, Biomedicine & Pharmacotherapy, Volume 112, 2019, 108604.
Sreedevi, Adikay; Saisruthi, Kaveripakam. Attenuation of Cisplatin-induced Nephrotoxicity by Ethanol Extract of Seeds of Lens Culinaris Medik. Ancient Science of Life 37(2):p 74-80, Oct–Dec 2017.
Spandana Uppuluri and Shaik Liakhat Ali and Thota Nirmala and Markapudi Shanthi and Babu Sipay and Kiran Babu Uppuluri Nephroprotector activity of hydro alcoholic extract of Tinospora cordifolia roots on cisplatin induced nephrotoxicity in rats Drug Invention Today volume (5) (4) 281-287, 2013.
YADAV, A. V., and C. D. UPASANI. “NEPHROPROTECTIVE ACTIVITY OF PLUMERIA RUBRA AGAINST CISPLATIN INDUCED NEPHROTOXICITY IN EXPERIMENTAL RATS”. International Journal of Pharmacy and Pharmaceutical Sciences, vol. 11, no. 4, Apr. 2019, pp. 108-13.
Yıldırım, Ayşegül and DEĞER, Necla and SAYAN, Meryem and Akin, Ali and Ceylan, Tayfun and Kaymak, Emin and KARA, Mehmet and ÜNSAL, Murat and Karabulut, Derya , Investigation of the effect of thymoquinone on kidney damage in isoproterenol-induced myocardial infarction in rats and cardiorenal interactions Experimental and Applied Medical Science 4, 515-525, 2023.
Ghane Shahrbaf F, Assadi F. Drug-induced renal disorders. J Renal Inj Prev. 2015 Sep 1;4(3):57-60. doi: 10.12861/jrip.2015.12. PMID: 26468475; PMCID: PMC4594214.
Shraddha I. Khairnar and Yogesh A. Kulkarni and Kavita Singh Mitigation of cisplatin-induced nephrotoxicity by chelidonic acid in Wistar rats Journal of Trace Elements in Medicine and Biology (81),127321, 2024.
20. Saraswati Patel and V. Sathyanathan and Samsi D. Salaman Molecular mechanisms underlying cisplatin-induced nephrotoxicity and the potential ameliorative effects of essential oils: A comprehensive review, Tissue and Cell, 88, 102377. 2024.
Al-Snafi, Ali and Talab, Tayseer A review of medicinal plants with nephroprotective effects GSC Biological and Pharmaceutical Sciences (8) 114-122:2019.
Buthelezi LG, Mavengahama S, Sibiya J, Mchunu CN, Ntuli NR. Phytochemical composition of Lagenaria siceraria fruits from KwaZulu-Natal and Limpopo, South Africa. Food Chem X. 2024 Mar 30; 22:101338.
Elsayed A. Elmorsy and Sameh Saber and Rabab S. Hamad and Mustafa Ahmed Abdel-Reheim and Attalla F. El-kott and Mohammed A. AlShehri and Kareem Morsy and Salama Advances in understanding cisplatin-induced toxicity: Molecular mechanisms and protective strategies, European Journal of Pharmaceutical Sciences, (203): 106939: 2024.
Adikay Sreedevi Nephroprotective Potential of Lens Culinaris Against Cisplatin-induced Nephrotoxicity Indian journal of Physiology Pharmacology 62 (1) 139-148: 2018.
Sreedevi, Adikay and Koganti, Bharathi and Prasad, Koganti, Effect of decoction of root bark of berberis aristata against cisplatin- induced nephrotoxicity in rats International Journal of Pharmacy and Pharmaceutical Sciences (2), 51-56:2010.
Alanezi AA, Almuqati AF, Alfwuaires MA, Alasmari F, Namazi NI, Althunibat OY, Mahmoud AM. Taxifolin Prevents Cisplatin Nephrotoxicity by Modulating Nrf2/HO-1 Pathway and Mitigating Oxidative Stress and Inflammation in Mice. Pharmaceuticals (Basel). 2022 Oct 24;15(11):1310.
Tanabe K, Tamura Y, Lanaspa MA, Miyazaki M, Suzuki N, Sato W, Maeshima Y, Schreiner GF, Villarreal FJ, Johnson RJ, Nakagawa T. Epicatechin limits renal injury by mitochondrial protection in cisplatin nephropathy. Am J Physiol Renal Physiol. 2012 Nov 1;303(9): F1264-74.
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