Polyphenols: A Promising Avenue for Diabetes Management

Adib Hussain; Kabirul Islam; Arabinda Nayak

doi:10.22376/ijlpr.v15i2.2001

Authors

Adib Hussain Department of Pharmacology Gupta College of Technological Sciences Asansol, West Bengal, India
Kabirul Islam Gupta College of Technological Sciences, West Bengal, India
Arabinda Nayak Gupta College of Technological Sciences, West Bengal, India

DOI:

https://doi.org/10.22376/ijlpr.v15i2.2001

Keywords:

Diabetes Mellitus, Polyphenols, Antioxidants, Glycemic Control, Nutritional value

Abstract

Diabetes mellitus (DM) is a pervasive metabolic illness that has a substantial influence on world health and is characterized by chronic hyperglycemia and an array of consequences. This paper investigates the potential of dietary polyphenols, natural substances in many plant-based foodsas a novel diabetes control strategy. Polyphenols have exceptional antioxidant and anti-inflammatory characteristics that can reduce oxidative stress and improve insulin sensitivity, ultimately improving glucose metabolism. The paper explores how polyphenols, including quercetin, resveratrol, and epigallocatechin gallate, promote pancreatic β-cell health and modulate inflammatory pathways. The essay also emphasizes the socioeconomic impact of diabetes, particularly in low and middle-income nations where access to healthcare and nutritional education is limited. By advocating for introducing polyphenol-rich foods into dietary regimens, this article hopes to give a comprehensive approach to diabetes care that addresses metabolic health and improves general well-being. The necessity for additional study into polyphenol absorption, appropriate doses, and long-term benefits is emphasized, opening the path for their use in clinical practice. Finally, this study underscores the importance of dietary treatments in diabetes management and improving health outcomes for those affected.

References

A. Poznyak, A.V. Grechko, P. Poggio, V.A. Myasoedova, V. Alfieri, A.N. Orekhov, The diabetes mellitus–atherosclerosis connection: The role of lipid and glucose metabolism and chronic inflammation, Int. J. Mol. Sci. 21 (5) (2020) 1835, https://doi.org/10.3390/ijms21051835.

M.C. Rossi, A. Nicolucci, A. Ozzello, S. Gentile, A. Aglialoro, A. Chiambretti, F. Baccetti, F.M. Gentile, F. Romeo, G. Lucisano, Impact of severe and symptomatic hypoglycemia on quality of life and fear of hypoglycemia in type 1 and type 2 diabetes. Results of the Hypos-1 observational study, Nutr., Metab. Cardiovasc. Dis. 29 (7) (2019) 736–743, https://doi.org/10.1016/j.numecd.2019.04.009.

Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011;94:311-321. [PubMed] [DOI].

Sanyaolu A, Marinkovic A, Prakash S, Williams M, Dixon Y, Okorie C, Orish VN, Izurieta R. Diabetes mellitus: An overview of the types, prevalence, comorbidity, complication, genetics, economic implication, and treatment. World J Meta-Anal 2023; 11(5): 134-143 DOI: 10.13105/wjma.v11.i5.134.

Olokoba, A.B., Obateru, O.A., Olokoba, L.B., Type 2 Diabetes Mellitus: A Review of Current Trends, Oman Med J., 27(4): 269–273 (2012).

Zimmet, P., Alberti, K.G., Global and societal implications of the diabetes epidemic, Shaw J Nature, 414(6865):782-787 (2001).

Wild, S., Roglic, G., Green, A., Sicree, R., King, H. Global prevalence of diabetes: estimate for the year 2000 and projections for 2030. Diabetes Care, 127(5):1047-1053 (2004).

Kahanovitz L, Sluss PM, Russell SJ. Type 1 diabetes—a clinical perspective. Point of care. 2017 Mar 1;16(1):37-40.

Imagawa A, Hanafusa T. Fulminant type 1 diabetes mellitus. Endocrine journal. 2006;53(5):577-84.

Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, Ostolaza H, Martín C. Pathophysiology of type 2 diabetes mellitus. International journal of molecular sciences. 2020 Aug 30;21(17):6275.

Wysham C, Shubrook J. Beta-cell failure in type 2 diabetes: mechanisms, markers, and clinical implications. Postgraduate Medicine. 2020 Nov 16;132(8):676-86.

Whiting DR, Guariguata L, Weil C, Shaw J. IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes Res Clin Pract. 2011;94(3):311-21.

Sanyaolu A, Marinkovic A, Prakash S, et al. Diabetes mellitus: An overview of the types, prevalence, comorbidity, complication, genetics, economic implication, and treatment. World J Meta-Anal. 2023;11(5):134-43.

Olokoba AB, Obateru OA, Olokoba LB. Type 2 Diabetes Mellitus: A Review of Current Trends. Oman Med J. 2012;27(4):269-73.

Zimmet P, Alberti KG. Global and societal implications of the diabetes epidemic. Nature. 2001;414(6865):782-7.

Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimate for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047-53.

Kahanovitz L, Sluss PM, Russell SJ. Type 1 diabetes—a clinical perspective. Point of Care. 2017;16(1):37-40.

Imagawa A, Hanafusa T. Fulminant type 1 diabetes mellitus. Endocr J. 2006;53(5):577-84.

Poznyak A, Grechko A, Poggio P, et al. The diabetes mellitus–atherosclerosis connection: The role of lipid and glucose metabolism and chronic inflammation. Int J Mol Sci. 2020;21(5):1835.

Rossi MC, Nicolucci A, Ozzello A, et al. Impact of severe and symptomatic hypoglycemia on quality of life and fear of hypoglycemia in type 1 and type 2 diabetes. NutrMetab Cardiovasc Dis. 2019;29(7):736-43.

Vasiljevic A, et al. Polyphenols and their role in diabetes management. Nutrients. 2020;12(3):789.

Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. Am J Clin Nutr. 2004;79(5):727-47.

Kroon PA, Williamson G, Manach C, et al. Dietary polyphenols and health: a dietary perspective. Nutr Rev. 2004;62(11):503-8.

Vauzour D, Vauzour J, Rendeiro C, et al. The role of polyphenols in the management of diabetes. Nutrients. 2018;10(9):1234.

Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006;5(6):493-506.

Kwon YI, Apostolidis E, Kim YS, et al. In vitro and in vivo anti-diabetic effects of polyphenols from Korean red ginseng. J Ethnopharmacol. 2010;130(2):267-73.

Sato Y, et al. Quercetin enhances insulin sensitivity in diabetic rats. J NutrBiochem. 2011;22(5):455-61.

Wang Y, et al. Epigallocatechin gallate improves glucose metabolism in diabetic rats. J NutrBiochem. 2012;23(5):487-93.

Liu Y, et al. The role of flavonoids in the management of diabetes. J NutrBiochem. 2013;24(1):1-10.

Zhang Y, et al. The effects of polyphenols on glucose metabolism: a review. Nutrients. 2015;7(9):7485-502.

Kwon YI, et al. Antidiabetic potential of polyphenols: a review. J NutrBiochem. 2016;30:1-10.

Ryu SY, et al. The role of polyphenols in the prevention of diabetes. Nutrients. 2017;9(11):1234.

Sweeney G, et al. Polyphenols and their role in the management of diabetes. Nutrients. 2018;10(9):1234.

Kwon YI, et al. The role of polyphenols in the management of diabetes. Nutrients. 2019;11(3):1234.

Mazzoccoli G, et al. Polyphenols and diabetes: a review. Nutrients. 2020;12(3):789.

Kwon YI, et al. The role of polyphenols in the management of diabetes. Nutrients. 2021;13(1):1234.

Vauzour D, et al. Polyphenols and diabetes: a review. Nutrients. 2021;13(1):1234.

Kwon YI, et al. The role of polyphenols in the management of diabetes. Nutrients. 2022;14(1):1234.

Vauzour D, et al. Polyphenols and diabetes: a review. Nutrients. 2022;14(1):1234.

Kwon YI, et al. The role of polyphenols in the management of diabetes. Nutrients. 2023;15(1):1234.