Synthesis, Characterization, Docking Study and Biological Evaluation of Substituted Pyrimidines
DOI:
https://doi.org/10.22376/ijlpr.v15i3.1995Keywords:
Chalcone, 2-thioPyrimidine, Anti-microbial activity, Ciprofloxacin, Molecular dockingAbstract
Objective: Synthesis and antimicrobial evaluation of a series of substituted pyrimidines.
Methods: A series of substituted pyrimidines (4a-g) were synthesized from the corresponding chalcones. The chalcones were prepared via Claisen Schimdt condensation between p-Chloroacetophenone and substituted benzaldehyde. These chalcones were then cyclized with thiourea in methanol medium via Michael’s addition to obtain substituted pyrimidines. All pyrimidine derivatives were characterized by IR (Infrared radiation), 1 HNMR (Proton nuclear magnetic resonance) spectral studies. Their in-vitro antimicrobial activity was evaluated using the cup-plate method. Molecular docking studies were conducted using PyRx and other computational tools.
Results: Some of the compounds have exhibited promising antimicrobial activities.
Conclusion: According to the activity studies, it is observed that the synthesis and antimicrobial activity of substituted pyrimidines have been shown better activity. Furthermore, the findings from molecular docking offer guidance on how to further modify the lead compound to enhance its inhibitory effectiveness.
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Copyright (c) 2025 Narendra B Gowda, Nisarga Prakash M, Rachana M L
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