Safety and Efficacy of Charakokta Raktapachak Yoga in Patients of Urticaria (Kotha) Caused Due to Dooshivisha – A Randomized Controlled Trial
Pharmaceutical sciences-Pharmacology
DOI:
https://doi.org/10.22376/ijlpr.2024.14.2.P1-P15Keywords:
Dooshivisha, Kotha, Urticaria, Raktapachak Yoga, kandu, daha, todaAbstract
This controlled clinical study aimed to assess the safety and efficacy of Charkokta Raktapachak Yoga in treating DooshivishajanyaKotha (urticaria), a condition known for its challenging recurrence. Two groups, each comprising 30 patients, were formed: a standard groupreceiving Tab. Cetrizine 10mg OD, and an experimental group receiving Tab. Raktapchak Yoga 500mg/day in two divided doses for 42 days.Follow-ups occurred every 7 days. The study evaluated manifestations such as raised edematous swelling (kotha), itching (kandu), burningsensation (daha), and pricking sensation (toda). Objective parameters like Hb, ESR, AEC, and stool examination were assessed before andafter the study. Statistical analysis revealed significant inter-group differences after treatment for urticaria (p = 0.0047), itching (p < 0.0001),pricking sensation (p = 0.0025), and burning sensation (p = 0.0018). In the experimental group, significant improvements were observed inobjective parameters: hemoglobin levels (p = 0.0026), ESR (p < 0.0001), AEC levels (p < 0.0001), and stool examination (p = 0.0176).Symptoms such as the urticarial wheel, itching, pricking, and burning sensation were alleviated more in the experimental group than in thecontrol group. Recurrence of symptoms was reduced in the experimental group post-treatment compared to the standard group. Objectiveparameters improved in the experimental group, affirms the safety and efficacy of Charkokta Raktapachak Yoga in treating urticaria caused byDooshivisha.
References
Dr. Bramhanand Tripathi C-S, Prakashan CS, Varanasi. Chikitsasthana 23/4-6. rev ed; 2007.
Shastri A, Samhita S, Kalpsthana. Vol. 18. Varanasi: Choukhamba Sanskrit Sansthana [reprint]; 2007,Page-427. p. 2/17.
Prof Shrikantha Murthy KR, Bhavaprakasha of Bhavmishra, Krishnadas Academy, Varanasi. 1st ed, 2000. Ch67-1.
Sushrut Samhita of Maharshi-Sushruta edited with Ayurved Tattva Sandipika by Kaviraj Ambikadutta Shastri Forwarded by Dr. Pranajivana Manekchanda Mehta Part I. Chaukhamba Sanskrit sansthan. 14th ed: 2003, Kalpasthan chapter no 2/verse no 25-33, page 25-6.
Bioaccumulation - https:. Wikipedia. Wikipedia. Available from: http://en.wikipedia.org/wiki/Bioaccumulation-assessed on 22/8/20223PM.
Sharma RK. CharakaSamhita, Chikitsa sthana,23/31,Varanasi,Choukhamba Sanskrit Sansthana,Page-339.
Sushrut Samhita of Maharshi-Sushruta edited with Ayurved Tattva Sandipika by Kaviraj Ambikadutta Shastri Forwarded by Dr. Pranajivana Manekchanda Mehta Part I. Chaukhamba Sanskrit sansthan. 14th ed: 2003, Kalpasthan chapter no 2/ verse no 30-32 page no 26.
Nidana M, Chapter 57, verse 1. Hindi Translation by Narendranath Shastri, Motilal banarasidas Pratisthana. Delhi. p. 638.
Available from: https://emedicine.medscape.com/article/762917-overview assessed on 31/10/22 3PM.
Losol P, Yoo HS, Park HS. Molecular genetic mechanisms of chronic urticaria. Allergy Asthma Immunol Res. 2014;6(1): 1321PMC 3881394:13-21:13-21. doi: 10.4168/aair.2014.6.1.13, PMID 24404388.
Sushrut Samhita of Maharshi-Sushruta edited with Ayurved Tattva Sandipika by Kaviraj Ambikadutta Shastri Forwarded by Dr. Pranajivana Manekchanda Mehta Part I. Chaukhamba Sanskrit sansthan. 14th ed: 2003, Kalpasthan chapter no 2/ verse no 53-54 page no 29.
Sharma RK, CharakaSamhita C. Varanasi,Choukhamba Sanskrit Sansthana,Page-343. p. 23/61-64.
Sharma RK. CharakaSamhita,Chikitsa sthana,3/202,Varanasi,Choukhamba Sanskrit Sansthana, Page-301.
Dr. Sastry JLN. illustrated DravyagunaVijnana: a study of the Essential Medicinal Plants in Ayurveda. 1st ed. Vol. II. Varanasi: Chaukhamba Orientalia; 1999.
Sharma RK. CharakaSamhita, sutra sthana,4,Varanasi,Choukhamba Sanskrit Sansthana, pages-245-253.
Shastri A, Samhita S, Sthana S, Varanasi CSS [reprint] 2007, pages-276-281.
Anonymous. Ayurvedic pharmacopoeia of India. Vol. I. New Delhi: Ministry of Family Health and Welfare. p. p. III, V.
Bhattacharya S, Haldar PK. Trichosanthes dioica root possesses stimulant laxative activity in mice. Nat Prod Res. 2012;26(10):952-7. doi: 10.1080/14786419.2010.535161, PMID 21827370.
Bhattacharya S, Haldar PK, Ghosh AK. Paralytic and lethal effects of Trichosanthes dioica root extracts in experimental worms. Pharm Biol. 2010 Sep;48(9):960-5. doi: 10.3109/13880200903311144, PMID 20695728.
Bhattacharya S, Haldar PK. Protective role of triterpenoid enriched extract of T. dioica root against experimentally induced pain and inflammation in rodents.
Kumar Rai P, Gupta SK, Srivastava A. Kumari, Gupta RK, Watal. GA Sci Validation Antihyperglycemic Antihyperlipidemic Attributes Trichosanthes dioicaISRN Pharmacol;2013:7.
Gayathri M, Kannabiran K. Antimicrobial activity of Hemidesmus indicus, Ficus bengalensis and Pterocarpus marsupium roxb. Indian J Pharm Sci. 2009;71(5):578-81. doi: 10.4103/0250-474X.58182, PMID 20502584.
Sundaram MS, Sivakumar T, Balamurugan G. Anti-inflammatory effect of Cyperus rotundus Linn. leaves on acute and subacute inflammation in experimental rat models. Biomedicine. 2008;28:302-4.
Gupta MB, Palit TK, Singh N, Bhargava KP. Pharmacological studies to isolate the active constituents from Cyperus rotundus possessing anti-inflammatory, antipyretic and analgesic activities. Indian J Med Res. 1971 Jan;59(1):76-82. PMID 5574385.
Singh N, Kulshrestha VK, Gupta MB, Bhargava KP. Pharmacological studies on Cyperus rotundus. Indian J Pharmacol. 1969;1(2):9.
Rem BJN. Swamy, Shivakumar & Hiremath, Suresh & Hallikeri, C.s & Hatapakki, B.C. & Handiganur, J.S. & Sankh, Kuber & Shivakumar. 2009. Anticonvulsant Effect of Cyperus rotundus Linn Rhizomes in Rats;9:192-6. doi: 10.18311/Jnr/2009/239.
Amresh G, Singh PN, Rao ChV. The antinociceptive and antiarthritic activity of Cissampelospareiraroots-Journal of Ethnopharmacology. J Ethnopharmacol. 2007;111(3):531-6. doi: 10.1016/j.jep.2006.12.026, PMID 17240096.
Amresh G, Reddy GD, Rao ChV, Singh PN. Evaluation of the anti-inflammatory activity of Cissampelos pareiraroot in rats. J Ethnopharmacol. 2007 Apr 4;110(3):526-31. doi: 10.1016/j.jep.2006.10.009, PMID 17097249.
Ganguly M, Borthakur Kr. M, Devi N, Mahanta R. Antifertility activity of the methanolic leaf extract of Cissampelos pareira in female albino rats. J Ethnopharmacol. 2007;111(3):688-91. doi: 10.1016/j.jep.2007.01.023, PMID 17324540.
Amresh G, Rao CV, Singh PN. Antioxidant activity of Cissampelos pareiraon benzo (a) pyrene-induced mucosal injury in mice. Nutr Res. 2007;27(10):625-32. doi: 10.1016/j.nutres.2007.05.009.
Badilla B, Chaves F, Jimenez S. Effects of an extract of Cissampelos pareiraon the hemorrhagic and proteolytic activities from Bothrops asper venom. Pharmacogn Mag. 2008;4:27-31.
Zhang DK, Yu JJ, Li YM, Wei LN, Yu Y, Feng YH, et al. A Picrorhiza kurroa Derivative, picroliv, Attenuates the Development of dextran-SulfateSodium-Induced Colitis in Mice. Mediators Inflamm. 2012;2012:751629. doi: 10.1155/2012/751629, PMID 23125487.
Dorsch W, Stuppner H, Wagner H, Gropp M, Demoulin S, Ring J. Antiasthmatic effects of Picrorhiza kurroa: androsin prevents allergen and PAF-induced bronchial obstruction in guinea pigs. Int Arch Allergy Appl Immunol. 1991;95(2-3):128-33. doi: 10.1159/000235416, PMID 1718906.
Rajeshkumar NV, Kuttan R. Protective Effect of picroliv, the Active Constituent of Picrorhiza kurroa, Against Chemical Carcinogenesis in Mice. Teratog Carcinog Mutagen. 2001;21(4):303-13. doi: 10.1002/tcm.1018, PMID 11406836.
Kumar PV, Sivaraj A, Madhumitha G, Saral AM, Kumar BS. In vitro antibacterial activities of Picrorhiza kurroa rhizome extract using agar well diffusion method. Int J Curr Pharm Res. 2010;2(1):30-3.
Gupta A, Khajuria A, Singh J, Bedi KL, Satti NK, Dutt P, et al. Immunomodulatory activity of biopolymeric fraction RLJ-NE-205 from Picrorhiza kurroa. Int Immunopharmacol. 2006;6(10):1543-9. doi: 10.1016/j.intimp.2006.05.002, PMID 16919826.
Sharma RK. CharakaSamhita,Chikitsa sthana,3/200-203,Varanasi,Choukhamba Sanskrit Sansthana, Page-301.
BhavprakashNighantu. By Acharya Bhava Mishra With Hindi commentary by K-Chunekar 7th Edi,Chaukhambha. Varanasi: Amara Bharati Academy; 1986.
Available from: https://www.mdcalc.com › calc › urticaria-activity-score. Asssed on 31/12/2023. 1:00PM.
Assessed on 31/12/2022;1:20PM.
Available from: https://pubmed.ncbi.nlm.nih.gov. Assessed on 31/12/2022. Vol. 2. 00 PM.
Available from: https://www.statisticshowto.com/probability-and-statistics/statistics-definitions/wilcoxon-signed-rank-test/Assessed on 31/12/2022;3:20 PM.
Available from: https://sixsigmastudyguide.com/mann-whitney-non-parametric-hypothesis-test/Assessed on 31/12/2022 3:45PM.
BK Mahajan methods in biostatistics, Chapter 9. Jaypee brothers Medical Publishers Ltd. In:. 6th ed; 2006, Page-147.
BK Mahajan methods in biostatistics, Chapter 9. Jaypee brothers Medical Publishers Ltd. In:. 6th ed; 2006, Page-142.
BK Mahajan methods in biostatistics, Chapter 11. Jaypee brothers Medical Publishers Ltd. In:. 6th ed; 2006, Page-168.
Available from: https://www.sciencedirect.com/science/article/abs/pii/S2213219817305378 assessed on 31/12/2022 3:00 PM.
Pradeep Patil et.al. Conceptual Study of Dooshivisha (Cumulative toxicity). Journal of Ayurveda and integrated medical sciences | Sep - Oct 2016 | Vol. 1 | Issue 3, p-149.
Sahu SC. Food additives: a special issue of the journal Food and Chemical Toxicology. Food Chem Toxicol. 2017;107(B):529. doi: 10.1016/j.fct.2017.05.018, PMID 28501486.
Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5949545/assessed o 31/12/2022;3:30 PM.
Shastri A, Samhita S, Varanasi SK. Choukhamba Sanskrit Sansthana [reprint]; 2007. p. 2/30-32, Page-423.
Sharma RK. CharakaSamhita,Chikitsa sthana,3/202,Varanasi,Choukhamba Sanskrit Sansthana, Page-301.
Mishra BR, Dhatupachak Yoga A. Int J Res Indian Med. 2018;2(1):1-8.
Dr.vandana chandel. International Research journal of Ayurveda and Yoga, IJRAY. Vol. 2(2, Mar-Apr); 2019. p. 57-63.
Rathod R, Thakre PP, Ade V. Evaluation of efficacy of Navakarshik Kwath Ghan in Sheetpitta WSR to urticaria. IJAM;11(3):441-5. doi: 10.47552/ijam.v11i3.1624.
Chavhan NS, Rathi B. Pharmaceutico-analytical study of Adraka Khanda. J Indian Sys Medicine. 2019;7(2):112-8. doi: 10.4103/JISM.JISM_19_19.
Shere A, Meenakshi R-K. Ayurvedic management of Shitpitta W.S.R. To urticaria- A Case Report, IAMJ August 2021, page-1896.
Priti L et al. Dooshivishari agada in Kotha (urticaria). J Indian Syst Vol. Apr-Jun 2018, Page-50.
European. J Mol Clin ISSN 2515. 2018;8260;05(1):447-53.
Avhad MR. Ayurvedic management of kitibha kushta- a case study. Ayurlog N Atl J Res Ayurved Sci. Apr 2020;8(02):2020;8,page-01-03.
Gabhane SM. Ayurvedic management of Vipadika Kushtha (palmoplantar psoriasis) – A single case study, IJCRR - 13. 2021;4(Feb):171-5.
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