A Case Study of Stomatitis Medicamentosa Due to Trigeminal Neuralgia Medication
Life Sciences- Dentistry
DOI:
https://doi.org/10.22376/ijlpr.2023.13.6.L557-L561Keywords:
Allergic stomatitis medicamentosa, IgE reaction, eosinophils, Adverse drug reaction, ulcerations.Abstract
Our study aim is to characterize and assess the case of Stomatitis medicamentosa in a patient who developed manyoral ulcers after using Carbamazepine for the treatment of Trigeminal Neuralgia of a 35-year-old female patient with a medicalhistory of hypertension for the past ten years and under medication. The patient also gave a history of electric shock-like painon the left side of the face for the past month and was prescribed Tegretol 100mg (Carbamazepine) twice daily. After taking thismedication, the patient suffered several mouth ulcers. The patient was asked to stop taking this medication and asked to takeoral antihistamines and systemic Gabapentin steroids for one month. After one week, the patient heals completely from thelesions. Burning sensation with altered taste sensation and difficulty while swallowing are common patient complaints. Mouthopening was restricted and painful. The skin test (prick test) is done, which shows red, papular, or vesicular reactions. Earlyidentification of the lesion and prompt withdrawal of the offending drug are key for successful management, and the drug can bereplaced with another drug of the same efficacy. Thus, adverse drug reactions can be minimised by asking the patient aboutallergy to any drug or food while writing a prescription, and the patient should be informed and familiarised with the drugpatient the patient is allergic.
References
Bankowski Z. Bruppach er R, Crusius I, Gallagher J,Kremer G, et al. In: International reporting of adverse drug reactionsCouncil for International Organizations of Medical Sciences. International reporting of adverse drug reactions; 2000. Available from: International Reporting of Adverse Drug Reactions - CIOMS.
Sivapathasundaram B. Allergic and immunological diseases of the oral cavity. In: Rajendran R, Sivapathasundaram B, editors. Shafer’stextbook of oralpathology.6thed. India: Elsevier; 2009. p. 673-4.
Lankerani L, Baron ED. Photosensitivity to exogenousagents. J Cutan Med Surg. 2004;8(6):424-31. doi: 10.1177/120347540400800604, PMID 15988550. Available from: Photosensitivity to Exogenous Agents.LankeraniL. Baron ED; 2004. Available from: sagepub.com.
Binnie WH, Burett AW, Wright. 3rdedCawson. J Oral Dis:13-3.
Neville BW, Damm DD, Allen CM, Chi AC. Oral and maxillofacial pathology. 3rded. Elsevier Health Sciences; 2009. p. 347-58.
AdkinsonJr NF. Risk factors for drug allergy. J allergy ClinImmunol. 1984Oct1;74;4:567-72. doi: 10.1016/0091-6749(84)90108-8, PMID 6491103. Available from: Risk factors for drug allergy - ScienceDirect.
Greenberger PA. Immunotherapy update: mechanisms of action. AsthmaProc. 2002;23(6):373-6. PMID 12528601(Vol. 23, No. 6, p. 373). OceanSide Publications. Available from:Immunotherapy update: Mechanisms of action — Northwestern Scholars.
Allison TJ, Winter CC, Fournié JJ, Bonneville M, Garboczi DN. Structure of a human γδ T-cell antigen receptor. Nature. 2001;411(6839):820-4. doi: 10.1038/35081115, PMID 11459064. Available from:Structure of a human γδ T-cell antigen receptor | Nature.
Greenberg MS. Ulcerative, vesicular and bullous lesions. In: Lynch MA, Brightman VJ, Greenberg MS, editors. Burket’soralmedicine,diagnosis and treatment. 9thed. Philadelphia: Lippincott; 2000. p. 23.
Krippaehne JA, Montgomery MT. Erythema multiforme: a literature review and case report. Spec Care Dentist. 1992;12(3):125-30. doi: 10.1111/j.1754-4505.1992.tb00428.x, PMID 1440131.
Hasan R, Akhtar N, Begum M, Ali ME, Paul HK, Zakaria A. Set al. Cutaneous morphological patterns of adverse drug reactions: a study of 50 cases. J Pak Assoc Dermatol. 2010;20(4):206-11.
Morhardt AC. Dinosaur smiles: do the texture and morphology of the premaxilla, maxilla, and dentary bones of sauropsids provide osteological correlates for inferring extra-oral structures reliably in dinosaurs? Western Illinois University; 2009.
Friedmann AM. Evaluation and management of lymphadenopathy in children. Pediatr Rev. 2008;29(2):53-60. doi: 10.1542/pir.29-2-53, PMID 18245301.
Pazhayattil GS, Shirali AC. Drug-induced impairment of renal function. Int J Nephrol Renovasc Dis 2014Dec12;7:457-68. 2014;7:457-68. doi: 10.2147/IJNRD.S39747, PMID 25540591.
De Sutter AI, Lemiengre M, Campbell H, Cochrane Acute Respiratory Infections Group. Antihistamines for the common cold. Cochrane Database Syst Rev 1996Sep1;2009(3).
Krishnaswamy G. Critical care management of the patient with anaphylaxis: a Concise definitive review. Crit Care Med. 2021;49(5):838-57. doi: 10.1097/CCM.0000000000004893, PMID 33653974.
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