A Comparative Study On Fractional Carbon-Dioxide Laser Versus Fractional CarbonDioxide Laser with Platelet Rich Plasma in Post-Acne Scars

Life Sciences-Dermatology

Abstract

Acne scars, irrespective of age and gender, can cause significant cosmetic problems with profound psychosocial impact. During thehealing process, aberrant production and degradation of collagen lead to various types of acne scars. Facial acne scars can be safely andeffectively treated with the help of high-energy, pulsed, or scanning carbon dioxide lasers with recent advances involving platelet-rich plasmaas a modality. Their beneficial potential rests on delivering a high concentration of growth factors to the target tissues. The study aims toassess the outcome of fractional carbon dioxide laser alone and with platelet-rich plasma (PRP) in treating post-acne scars. This is a singlecentre randomized study comparing the efficacy of fractional carbon dioxide laser resurfacing and fractional carbon dioxide + PRP in thetreatment of post-acne scars involving 30 patients, with 15 patients in group 1 receiving only fractional carbon dioxide laser and 15 patients ingroup 2 receiving fractional carbon dioxide + PRP. In this study, though both groups exhibited significant improvement at final follow-up,patients in the fractional carbon dioxide with PRP group showed a more significant change in quantitative assessment from visit to visitcompared to those in the fractional carbon dioxide laser group, indicating that topical PRP helped further diminish the scars and improved thetexture of scars and also helped in reducing the incidence of side effects as patients in the fractional carbon dioxide laser group exhibitedsome side effects like hypopigmentation and hyperpigmentation. Our study has concluded that although fractional carbon dioxide laser aloneand fractional carbon dioxide laser with platelet-rich plasma had significant results, the latter group had slightly better results with no sideeffects.