Oral Manifestations in Diabetes Mellitus and Management Considerations: A Review

Life Sciences- Oral Medicine

Authors

  • Dr. Prasanna R. Sonar Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Higher Education & Research (Deemed to be university), Sawangi-Meghe, Wardha (Maharastra), India. https://orcid.org/0000-0003-2267-9539
  • Dr. Aarati S. Panchbhai Prof, Department of Oral Medicine and Radiology.Sharad Pawar Dental College & Hospital, Datta Meghe Institute of Higher Education & Research (Deemed to be University), Sawangi-Meghe, Wardha (Maharastra), India.
  • Dr. Sunil Mishra Professor and Head, Department of Oral Medicine and Radiology, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune.
  • Dr. Suwarna B. Dangore Professor, Department of Oral Medicine and Radiology, Sharad Pawar Dental College and Hospital, DMIHER (DU)

DOI:

https://doi.org/10.22376/ijlpr.2023.13.6.L349-L357

Keywords:

Diabetes mellitus, Oral manifestations, Diabetic patients, Periodontal disease, Xerostomia, Oral infections, Mucosal alterations

Abstract

Diabetes mellitus is a chronic metabolic disorder defined as an increase in sugar levels in the bloodstream brought onby either insufficient insulin secretion, resistance to insulin's effects, or both. All age groups are affected by the chronic conditionknown as diabetes mellitus. It is among the world's major causes of mortality and morbidity. Xerostomia, dental caries,periodontal disease, gingivitis, candidiasis, other oral infections, burning mouth syndrome, taste dysfunction, oral mucosalalterations, delayed wound healing, and localized osteitis are common oral manifestations of diabetes mellitus. Majorcomplications impacting a patient's quality of life include oral complications in diabetic individuals. Long-term oral problems inthese patients’ harm blood glucose regulation, making oral complications care and prevention important. The dental professionalshould be familiar with DM's oral manifestations to identify this disease complication. This article not only discusses the oralmanifestations but also discusses management considerations in diabetic patients which will help future dental professionals indental practice. This article aims to spread knowledge and awareness about the potential oral manifestations of diabetes mellitusand treatment considerations.Keywords: , , , , ,

References

Shafer’s textbook of oral pathology. 7th ed.

Rohani B. Oral manifestations in patients with diabetes mellitus. World J Diabetes. 2019;10(9):485-9. doi: 10.4239/wjd.v10.i9.485, PMID 31558983.

Tandon N, Ali MK, Narayan KMV. Pharmacologic prevention of microvascular and macrovascular complications in diabetes mellitus: implications of the results of recent clinical trials in type 2 diabetes. Am J Cardiovasc Drugs. 2012;12(1):7-22. doi: 10.2165/11594650-000000000-00000, PMID 22217193.

American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2009;32;Suppl 1(Suppl 1):S62-S67:S62-7. doi: 10.2337/dc09-S062, PMID 19118289.

Mauri-Obradors E, Estrugo-Devesa A, Jané-Salas E, Viñas M, López-López J. Oral manifestations of Diabetes Mellitus. A systematic review. Med Oral Patol Oral Cir Bucal. 2017 Sep 1;22(5):e586-94. doi: 10.4317/medoral.21655, PMID 28809366.

Pradeepa R, Mohan V. Epidemiology of type 2 diabetes in India. Indian J Ophthalmol. 2021 Nov;69(11):2932-8. doi: 10.4103/ijo.IJO_1627_21, PMID 34708726.

World Health Organization. Fact Sheet No. 312. Diabetes. 2011;2011. p.

Albert DA, Ward A, Allweiss P, Graves DT, Knowler WC, Kunzel C, et al. Diabetes and oral disease: implications for health professionals. Ann N Y Acad Sci. 2012;1255:1-15. doi: 10.1111/j.1749-6632.2011.06460.x, PMID 22409777.

Cicmil S, Mladenović I, Krunić J, Ivanović D, Stojanović N. Oral alterations in diabetes mellitus. Balkan J Dent Med. 2018;22(3):7-14. doi: 10.2478/bjdm-2018-0002.

Al-Maskari AY, Al-Maskari MY, Al-Sudairy S. Oral Manifestations and Complications of Diabetes Mellitus: a review. Sultan Qaboos Univ Med J. 2011;11(2):179-86. PMID 21969888.

Cicmil A, Govedarica O, Lečić J, Mališ S, Cicmil S, Čakić S. Oral symptoms and mucosal lesions in patients with diabetes mellitus Type 2. Balkan J Dent Med. 2017;21(3):50-4. doi: 10.1515/bjdm-2017-0007.

Mauri-Obradors E, Estrugo-Devesa A, Jané-Salas E, Viñas M, López-López J. Oral manifestations of Diabetes Mellitus. A systematic review. Med Oral Patol Oral Cir Bucal. 2017;22(5):e586-94. doi: 10.4317/medoral.21655, PMID 28809366 [PMID: 28809366 DOI: 10.4317/medoral.21655].

Ship JA. Diabetes and oral health: an overview. J Am Dent Assoc. 2003;134;Spec No:4S-10S. doi: 10.14219/jada.archive.2003.0367, PMID 18196667.

Khan T. Oral manifestations and complications of diabetes mellitus: a review. Int J Health Res. 2018;4:50-2. doi: 10.22271/ijmhr.

Kapourani A, Kontogiannopoulos KN, Manioudaki AE, Poulopoulos AK, Tsalikis L, Assimopoulou AN et al. A review on xerostomia and its various management strategies: the role of advanced polymeric materials in the treatment approaches. Polymers. 2022 Feb 22;14(5):850. doi: 10.3390/polym14050850, PMID 35267672.

Villa A, Connell CL, Abati S. Diagnosis and management of xerostomia and hyposalivation. Ther Clin Risk Manag. 2015;11:45-51. doi: 10.2147/TCRM.S76282, PMID 25653532.

Escobar A, Aitken-Saavedra JP. Xerostomia: an update of causes and treatments. Salivary glands-new approaches Diagn treat. 2018 Nov 5;1(11):1-2.

Glick M. Burket’s oral medicine. 12th ed.

Arrieta-Blanco JJ, Bartolomé-Villar B, Jiménez-Martinez E, Saavedra-Vallejo P, Arrieta-Blanco FJ. Bucco-dental problems in patients with Diabetes Mellitus (I): index of plaque and dental caries. Med Oral. 2003;8(2):97-109. PMID 12618670.

Indurkar MS, Maurya AS, Indurkar S. Oral manifestations of diabetes. Clin Diabetes. 2016;34(1):54-7. doi: 10.2337/diaclin.34.1.54, PMID 26807010 [PMID: 26807010 DOI: 10.2337/diaclin.34.1.54].

Daniel R, Gokulanathan S, Shanmugasundaram N, Lakshmigandhan M, Kavin T. Diabetes and periodontal disease. J Pharm Bioallied Sci. 2012;4;Suppl 2:S280-2. doi: 10.4103/0975-7406.100251, PMID 23066270 [PMID: 23066270 DOI: 10.4103/0975-7406.100251].

Negrato CA, Tarzia O. Buccal alterations in diabetes mellitus. Diabetol Metab Syndr. 2010;2:3. doi: 10.1186/1758-5996-2-3, PMID 20180965.

Preshaw PM, Bissett SM. Periodontitis and diabetes. Br Dent J. 2019;227(7):577-84. doi: 10.1038/s41415-019-0794-5, PMID 31605062.

Taboza ZA, Costa KL, Silveira VR, Furlaneto FA, Montenegro R, Russell S et al. Periodontitis, edentulism and glycemic control in patients with type 2 diabetes: a cross-sectional study. BMJ Open Diabetes Res Care. 2018;6(1):e000453. doi: 10.1136/bmjdrc-2017-000453, PMID 29607049 [PMID: 29607049 DOI: 10.1136/bmjdrc-2017-000453].

Rodrigues CF, Rodrigues ME, Henriques M. Candida sp. Infections in patients with diabetes mellitus. J Clin Med. 2019;8(1). doi: 10.3390/jcm8010076, PMID 30634716 [PMID: 30634716 DOI: 10.3390/jcm8010076].

Garcia-Cuesta C, Sarrion-Pérez MG, Bagán JV. Current treatment of oral candidiasis: A literature review. J Clin Exp Dent. 2014 Dec;6(5):e576-82. doi: 10.4317/jced.51798, PMID 25674329.

Spanemberg JC, Rodríguez de Rivera Campillo E, Salas EJ, López López J. Burning Mouth Syndrome: update. Oral Health Dent Manag. 2014;13(2):418-24. doi: 10.12974/2311-8695.2014.02.01.2, PMID 24984658.

Ritchie A, Kramer JM. Recent advances in the etiology and treatment of burning mouth syndrome. J Dent Res. 2018 Oct;97(11):1193-9). doi: 10.1177/0022034518782462, PMID 29913093.

Leite RS, Marlow NM, Fernandes JK, Hermayer K. Oral Health and type 2 diabetes. Am J Med Sci. 2013;345(4):271-3. doi: 10.1097/MAJ.0b013e31828bdedf, PMID 23531957.

Tsujimoto T, Imai K, Kanda S, Kakei M, Kajio H, Sugiyama T. Sweet taste disorder and vascular complications in patients with abnormal glucose tolerance. Int J Cardiol. 2016;221:637-41. doi: 10.1016/j.ijcard.2016.07.062, PMID 27423082 [PMID: 27423082 DOI: 10.1016/j.ijcard.2016.07.062].

Hsieh JW, Daskalou D, Macario S, Voruz F, Landis BN. How to manage taste disorders. Curr Otorhinolaryngol Rep. 2022 Dec;10(4):385-92. doi: 10.1007/s40136-022-00428-z, PMID 36158900.

Kadir T, Pisiriciler R, Akyüz S, Yarat A, Emekli N, Ipbüker A. Mycological and cytological examination of oral candidal carriage in diabetic patients and non-diabetic control subjects: thorough analysis of local aetiologic and systemic factors. J Oral Rehabil. 2002;29(5):452-7. doi: 10.1046/j.1365-2842.2002.00837.x, PMID 12028493.

Guggenheimer J, Moore PA, Rossie K, Myers D, Mongelluzzo MB, Block HM, et al. Insulin-dependent diabetes mellitus and oral soft tissue pathologies: II. Prevalence and characteristics of Candida and candidal lesions. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2000;89(5):570-6. doi: 10.1067/moe.2000.104477, PMID 10807713.

Petrou-Amerikanou C, Markopoulos AK, Belazi M, Karamitsos D, Papanayotou P. Prevalence of oral lichen planus in diabetes mellitus according to the type of diabetes. Oral Dis. 1998;4(1):37-40. doi: 10.1111/j.1601-0825.1998.tb00253.x, PMID 9655043.

Abiko Y, Selimovic D. The mechanism of protracted wound healing on oral mucosa in diabetes. Review [review] [review]. Bosn J Basic Med Sci. 2010;10(3):186-91. doi: 10.17305/bjbms.2010.2683, PMID 20846123 [PMID: 20846123 DOI: 10.17305/bjbms.2010.2683].

Spampinato SF, Caruso GI, De Pasquale R, Sortino MA, Merlo S. The treatment of impaired wound healing in diabetes: looking among old drugs. Pharmaceuticals (Basel). 2020 Apr 1;13(4):60. doi: 10.3390/ph13040060, PMID 32244718.

Babu K, Adiga K, Dsouza L, Poonja P, Bhandarkar G, Rao PK et al. Oral manifestations in diabetes mellitus. Dent. 2019;1:28-30.

Textbook of oral medicine-Anil G R and Savita AG. 3rd ed.

Soysa NS, Samaranayake LP, Ellepola AN. Diabetes mellitus as a contributory factor in oral candidosis. Diabet Med. 2006;23(5):455-9. doi: 10.1111/j.1464-5491.2005.01701.x, PMID 16681553.

Garola F, Gilligan G, Panico R, Leonardi N, Piemonte E. Clinical management of alveolar osteitis. A systematic review. Med Oral Patol Oral Cir Bucal. 2021 Nov;26(6):e691-702. doi: 10.4317/medoral.24256, PMID 34704976.

Miller A, Ouanounou A. Diagnosis, management, and dental considerations for the diabetic patient. J Can Dent Assoc. 2020;86:(k8). PMID 32543368.

Shahbaz M, Kazmi F, Majeed HA, Manzar S, Qureshi FA, Rashid S. Oral manifestations: A reliable indicator for undiagnosed diabetes mellitus patients. Eur J Dent. 2022 Oct 11. doi: 10.1055/s-0042-1755553, PMID 36220121.

Published

2023-11-01

How to Cite

R. Sonar, D. P. ., S. Panchbhai, D. A. ., Mishra, D. S. ., & B. Dangore, D. S. . (2023). Oral Manifestations in Diabetes Mellitus and Management Considerations: A Review : Life Sciences- Oral Medicine. International Journal of Life Science and Pharma Research, 13(6), L349-L357. https://doi.org/10.22376/ijlpr.2023.13.6.L349-L357

Issue

Section

Review Articles