Curcumin's Role in Dentistry: A Review of Herbal Drugs
Pharmaceutical Science-Oral medicine
DOI:
https://doi.org/10.22376/ijlpr.2023.13.6.P120-P126Keywords:
Curcumin Longa, polyphenols, Ayurveda, Therapeutic, Tangerine-brown, subgingival IrritantAbstract
Before antiquated duration, seasonings had been a substantial wellspring of medication. Turmeric (diferuloylmethane) is a tangerine-brown part of Curcumin (Curcuma aromatica),a flavor frequently originated in powdered curry. Generally remembered for its calming impacts, Curcumin longa possess extended past of therapeutic usage in Ayurveda and frameworks ofmedication from China. Curcumin can be used as a mouthwash, pit and gap filler, and subgingival irritant in various combinations. It has also been connected to a variety of pharmacologicalactions such as cancer prevention, antimicrobial properties, and soothing effects. Haldi is the local drug delivery system in clotting structure. The following article presents with an elevatedperspective mostly on the organic exercises of the miswak and conceivable restorative and dental applications. Turmeric is one of the most well-known spices that has been used for a longtime and is an important component of ancient medicine. It's harmless and has a variety of restorative applications, including dental use. The purpose of this essay is to look at the other oralcavity uses of turmeric because of lack of data and study of the area. The motive of the following write-up is to assess the potency of Curcumin longa spice for maintaining dental wellbeingspecifically, as well as overall wellbeing. Haldi or Indian saffron, is a spice with therapeutic characteristics and is reliable and reasonable choice. It also shown cancer-prevention, antibacterial,germ-free activities. It is also highly useful in dentistry because of these qualities. It aids in the treatment of periodontal disease and other dental illnesses. Turmeric can be used in a variety ofways, including as a pit and crevice sealer, mouthwash, and subgingival irritant. It can be additionally used a topical application in a coagulant format. Turmeric (Curcumin) is a well-known spicewith ancient medicinal uses, particularly in Ayurveda and Chinese medicine. Its tangerine-brown component, Curcumin longa, has been extensively utilized for its anti-inflammatory properties.In dentistry, Curcumin has found various applications, including as a mouthwash, pit and gap filler, and subgingival irritant in different combinations. Additionally, it exhibits pharmacologicalactions such as cancer prevention, antimicrobial effects, and soothing properties. The present article provides an overview of the organic activities of Curcumin, particularly its potentialtherapeutic and dental applications. Turmeric has a long history of safe use and has been a crucial component of traditional medicine. However, research on its oral cavity uses is limited,warranting further investigation in this area. The focus of this essay is to evaluate the efficacy of Curcumin in maintaining dental and overall wellbeing. As Haldi or Indian saffron, it offersreliable and affordable therapeutic benefits. Its demonstrated cancer-preventive, antibacterial, and germicidal activities make it highly valuable in dentistry, aiding in the treatment of periodontaldiseases and other dental ailments. Turmeric can be utilized in various forms, such as a pit and crevice sealer, mouthwash, and subgingival irritant. Moreover, it can be applied topically in acoagulant format to address dental issues effectively. Given its extensive historical use and promising medicinal properties, Curcumin remains a valuable asset in the realm of dentistry.
References
Nagpal M, Sood S. Role of curcumin in systemic and oral health: an overview. J Nat Sci Biol Med. 2013;4(1):3-7 [doi: 10.4103/0976-9668.107253] [Pubmed:23633828].
Labban L. Medicinal and pharmacological properties of Turmeric (Curcuma longa): a review. Int J Pharm Biomed Sci. 2014;5(1):17-23.
Krup V, Prakash LH, Harini A. Pharmacological activities of turmeric (Curcuma longa Linn): a review. J Homeop Ayurv. Med. 2013;2(133):2167-1206.
Kapgate TD, Bhowate RR, Dangore S, Meshram M, Lohe VK. Effect of turmeric on serum malondialdehyde in oral submucous fibrosis. Int J Curr Res Rev. 2020 Dec;12(23):129-35 [doi: 10.31782/IJCRR.2020.122313].
Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003 1 Feb;9(1):161-8 [doi: 10.1089/107555303321223035] [Pubmed:12676044].
Grover HS, Deswal H, Bhardwaj A. Curcumin: A medicinal plant and its effects in medicine and dentistry. Int J Contemp Dent Med Rev. 2015;2015.
Wahlström B, Blennow G. A study on the fate of curcumin in the rat. Acta Pharmacol Toxicol (Copenh). 1978 Aug;43(2):86-92 [doi: 10.1111/j.1600-0773.1978.tb02240.x] [Pubmed:696348].
Ravindranath V, Chandrasekhara N. Absorption and tissue distribution of curcumin in rats. Toxicology. 1980;16(3):259-65 [doi: 10.1016/0300-483x(80)90122-5] [Pubmed:7423534].
Chaturvedi TP. Uses of turmeric in dentistry: an update. Indian J Dent Res. 2009 1 Jan;20(1):107-9 [doi: 10.4103/0970-9290.49065] [Pubmed:19336870].
Ramirez-Boscá A, Soler A, Carrión Gutierrez MA, Laborda Alvarez J, Quintanilla Almagro E. Antioxidant curcumaextracts decrease the blood lipid peroxide levels of human subjects. Age. 1995;18(4):167-9 [doi: 10.1007/BF02432631].
Toda S, Miyase T, Arich H. Natural antioxidants. Antioxidative compounds isolated from rhizome of Curcuma longa L. Chem Pharmacol Bul 1985; 33; 1725-28.
Motterlini R, Foresti R, Bassi R, Green CJ. Curcumin, an anti-oxidantand anti inflammatory agent, induces heme oxygenase 1 andprotects endothelial cells against oxidative stress. Free Radic Biol Med. 2000;28(8):1303-12 [doi: 10.1016/s0891-5849(00)00294-x] [Pubmed:10889462].
Mukhopadhyay A, Basu N, Ghatak N, Gujral PK. Anti-inflammatory and irritant activities of curcumin analogues in rats. Agents Actions. 1982;12(4):508-15 [doi: 10.1007/BF01965935] [Pubmed:7180736].
Scrobota I, Bolfa P, Filip AG, Catoi C, Alb C, Pop O et al. Natural chemopreventive alternatives in oral cancer chemoprevention. J Physiol Pharmacol. 2016 1 Feb;67(1):161-72 [Pubmed:27010905].
Subasree S, Murthykumar K, Sripradha S, Naveed N. Effects of turmeric on oral health: an overview. Int J PharmSci Health Care. 2014;2:6-14.
Suhag A, Dixit J, Dhan P. Role of curcumin as a subgingival irrigant: a pilot study. Periodont Pract Today. 2007 1 Apr;4(2).
Waghmare PF, Chaudhari AU, Karhadkar VM, Jamkhande AS. Comparative evaluation of turmeric and chlorhexidine gluconate mouthwash in prevention of plaque formation and gingivitis: a clinical and microbiological study. J Contemp Dent Pract. 2011;12(4):221-4 [doi: 10.5005/jp-journals-10024-1038] [Pubmed:22186854].
Subasree S, Murthykumar K, Sripradha S, Naveed N. Effects of turmeric on oral health: an overview. Int J PharmSci Health Care. 2014;2:6-14.
Behal R, Mali AM, Gilda SS, Paradkar AR. Evaluation of local drug delivery system containing 2% whole turmeric gel used as an adjunctto scaling and root planning in chronic periodontitis: A clinical andmicrobiological study. J Indian Soc Periodontol. 2011;15(1):35-8 [doi: 10.4103/0972-124X.82264] [Pubmed:21772719].
Ammon HP, Wahl MA. Pharmacology of Curcuma longa. Planta Med. 1991 Feb;57(1):1-7 [doi: 10.1055/s-2006-960004] [Pubmed:2062949].
Bisht S, Feldmann G, Soni S, Ravi R, Karikar C, Maitra A, Maitra A. Polymeric nanoparticle-encapsulated curcumin (’nanocurcumin’): a novel strategy for human cancer therapy. J Nanobiotechnology. 2007 Dec;5(1):3 [doi: 10.1186/1477-3155-5-3] [Pubmed:17439648].
Agarwal N, Singh D, Sinha A, Srivastava S, Prasad RK, Singh G. Evaluation of efficacy of turmeric in management of oral submucous fibrosis. J Indian Acad Oral Med Radiol. 2014 1 Jul;26(3):260 [doi: 10.4103/0972-1363.144998].
Anuchapreeda S, Tima S, Duangrat C, Limtrakul P. Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines. Cancer Chemother Pharmacol. 2008 Sep;62(4):585-94 [doi: 10.1007/s00280-007-0642-1] [Pubmed:18034345].
Dixit J, Verma U, Karamjeet R, Sharma R, Balapure AK. Role of insulin as a growth promoter in regulating the response of curcumin in human primary gingival fibroblasts: an in vitro study. J Indian Soc Periodontol. 2009 Sep;13(3):133-7 [doi: 10.4103/0972-124X.60225] [Pubmed:20379410].
Dyavanagoudar SN. Oral submucous fibrosis: review on etiopathogenesis. JCST. 2009;1(2).
Yadav M, Aravinda K, Saxena VS, Srinivas K, Ratnakar P, Gupta J et al. Comparison of curcumin with intralesional steroid injections in Oral submucous Fibrosis–A randomized, open-label interventional study. J Oral Biol Craniofac Res. 2014 1 Sep;4(3):169-73 [doi: 10.1016/j.jobcr.2014.11.003] [Pubmed:25737939].
El Khoury E, Abiad M, Kassaify ZG, Patra D. Green synthesis of curcumin conjugated nanosilver for the applications in nucleic acid sensing and anti-bacterial activity. Colloids Surf B Biointerfaces. 2015 1 Mar;127:274-80 [doi: 10.1016/j.colsurfb.2015.01.050] [Pubmed:25687098].
Tang W, Du M, Zhang S, Jiang H. Therapeutic effect of curcumin on oral diseases: A literature review. Phytother Res. 2020;35(5):2287-95 [doi: 10.1002/ptr.6943] [Pubmed:33205472].
Thakur A, Kumar A, Hasan S, Saeed S. Curcumin in oral mucosal lesions: an update. Asian J Pharm Clin Res. 2019;12:32-43.
Wikipedia. https://en.wikipedia.org/wiki/File:Curcuma_longa_roots.jpg. Accessed 28/7/2023. Wikipedia.
Nosratzehi T. Oral lichen planus: an overview of potential risk factors, biomarkers and treatments. Asian Pac J Cancer Prev. 2018;19(5):1161-7 [doi: 10.22034/APJCP.2018.19.5.1161] [Pubmed:29801395].
Bhatia M, Urolagin SS, Pentyala KB, Urolagin SB, K B M, Bhoi S. Novel therapeutic approach for the treatment of periodontitis by curcumin. J Clin Diagn Res. 2014 Dec;8(12):ZC65-9 [doi: 10.7860/JCDR/2014/8231.5343] [Pubmed:25654035].
Published
How to Cite
Issue
Section
Copyright (c) 2023 Sakshi Pramod Nathani, Dr. Ravikant Sune, Dr Vidya Lohe, Dr Priyanka Paul Madhu
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
