Updated Detailed Review of Trachyspermum Ammi: Composition, Applications and Pharmacological Profile
Pharmaceutical Science-Pharmacy
DOI:
https://doi.org/10.22376/ijlpr.2023.13.5.P221-P238Keywords:
Trachyspermum Ammi, Herbal formulations, Phytoconstituents, Patents, Microwave-Assisted Extraction.Abstract
Trachyspermum Ammi (T. Ammi) is a traditional medicinal plant belonging to the family Apiaceae. It, also known asAjacine or Ajwain, is an herb with Egyptian origins. It is distributed all over India and mainly cultivated in Rajasthan and Gujarat.This review is designed to discuss the updated pharmacological activities of T. Ammi, its phytochemistry, herbal formulations,and patents filed on its novel formulations and their actions. Until now, no such review has discussed the above mentionedparticulars on the same platform. The review aims to provide the updated traditional and pharmacological activities of T. Ammi,along with its phytochemistry, herbal formulations, and microwave-assisted extraction method. The microwave-assistedextraction method is less time-consuming, cost-effective, and gives more extractive value than other methods. We have alsoadded the latest novel patents of the T.ammi. It is an annual plant with tall growth that is fragrant and bears white blooms andlittle brownish berries, small, grey, bitter, and peppery. The seeds or fruit of this plant are the parts that are used mostfrequently. Ajwain's fruits have 5% essential oil in them. Ancient researchers highly influenced the use of this herb. The essentialoil brings on Ajwain's aroma and flavor. Ajwain is a potent traditional medicine that is frequently used to cure a variety ofillnesses in both humans and animals. To include literature evidence to support the article's theme, a search was performed onfive electronic databases, including PubMed, Scopus, Web of Science, Embase, and Google Scholar, by using specific keywords.
References
Hyder M, Li Y, Wang M, Mao J, Mari JM, Bukero A et al. Insecticidal activity, Chemical Constituents of Trachyspermum Ammi, Withania coagulans and Murraya koenigii ethanloic extracts against Bemisia tabaci. Braz J Biol. 2022 Aug 1;84:e260298. doi: 10.1590/1519-6984.260298, PMID 35920500.
Morsy NFS. Production of thymol rich extracts from ajwain (Carum copticum L.) and thyme (Thymus vulgaris L.) using supercritical CO2. Ind Crops Prod. 2020 Mar 1;145:112072. doi: 10.1016/j.indcrop.2019.112072.
Bairwa R, Sodha RS, Rajawat BS. Trachyspermum Ammi. Pharmacogn Rev. 2012 Jan;6(11):56-60. doi: 10.4103/0973-7847.95871, PMID 22654405.
Imani-Baran A, Abdollahi J, Akbari H, Jafarirad S, Moharramnejad S. Anthelmintic activity of crude powder and crude aqueous extract of Trachyspermum Ammi on gastrointestinal nematodes in donkey (Equus asinus): an in vivo study. J Ethnopharmacol. 2020 Feb 10;248:112249. doi: 10.1016/j.jep.2019.112249, PMID 31557509.
Sonar PK, Singh R, Saraf SK. Phytochemical, chromatographic and spectroscopic investigation of Carum copticum seeds and their potential as immunomodulatory agents. Pharm Biol. 2016 Mar 3;54(3):494-502. doi: 10.3109/13880209.2015.1050116, PMID 26030463.
Ramakrishna C, Pamisetty A, Reddy SR. Nutraceutical enriched Indian traditional chikki. J Food Sci Technol. 2015 Aug;52(8):5138-46. doi: 10.1007/s13197-014-1625-y, PMID 26243935.
Chahal KK, Dhaiwal K, Kumar A, Kataria D, Singla N. Chemical composition of Trachyspermum Ammi L. and its biological properties: a review. J Pharmacogn Phytochem. 2017;6(3):131-40.
Mahboubi M, Kazempour N. Chemical composition and antimicrobial activity of Satureja hortensis and Trachyspermum copticum essential oil. Iran J Microbiol. 2011 Dec;3(4):194-200. PMID 22530088.
Hejazian SH, Bagheri SM, Safari F. Spasmolytic and anti-spasmodic action of Trachyspermum Ammi essence on rat’s ileum contraction. North Am J Med Sci. 2014 Dec;6(12):643-7. doi: 10.4103/1947-2714.147982, PMID 25599053.
Syed S, Al-Haq MI, Saddiqui MH, Aslam Z. Growth and yield response of ajwain (Carum copticum L.) to sowing date and row spacing. Pak J Life Soc Sci. 2015 Dec 14;13:157-61.
Bashyal SA, Guha AV. Evaluation of Trachyspermum Ammi seeds for antimicrobial activity and phytochemical analysis. Asian J Pharm Clin Res. 2018;11(5):148-222. doi: 10.22159/ajpcr.2018.v11i5.24430.
Moazeni M, Saharkhiz MJ, Hosseini AA. In vitro lethal effect of ajowan (Trachyspermum Ammi L.) essential oil on hydatid cyst protoscoleces. Vet Parasitol. 2012 Jun 8;187(1-2):203-8. doi: 10.1016/j.vetpar.2011.12.025, PMID 22245070.
Monfared AA, Mousavi SA, Zomorodian K, Mehrabani D, Iraji A, Moein MR. Trachyspermum Ammi aromatic water: A traditional drink with considerable anti-Candida activity. Curr Med Mycol. 2020 Sep;6(3):1-8. doi: 10.18502%2Fcmm.6.3.3979.
Available from: https://patents.google.com/patent/KR101241180B1/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi (Access on 31/03/2023). Google.
Available from: https://patents.google.com/patent/AU2019200802A1/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi (Access on 31/03/2023). Google.
Available from: https://patents.google.com/patent/US20200390696A1/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi (Access on 31/03/2023). Google.
Available from: https://patents.google.com/patent/US9532593B2/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi (Access on 31/03/2023). Google.
Available from: https://patents.google.com/patent/US9801845B2/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi (Access on 31/03/2023). Google.
Available from: https://patents.google.com/patent/US20220408734A1/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi&page=4 (Access on 31/03/2023). Google.
Available from: https://patents.google.com/patent/EP2949362B1/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi&page=4 (Access on 31/03/2023). Google.
Available from: https://patents.google.com/patent/US10130095B2/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi&page=9 (Access on 31/03/2023). Google.
Available from: https://patents.google.com/patent/WO2015000064A1/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi&page=9 (Access on 31/03/2023). Google.
Available from: https://patents.google.com/patent/US20200397711A1/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi&page=9 (Access on 31/03/2023). Google.
Available from: https://patents.google.com/patent/WO2006068759A2/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi&page=9 (Access on 31/03/2023). Google.
Available from: https://patents.google.com/patent/US20170348449A1/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi&page=9 (Access on 2/04/2023). Google.
Available from: https://patents.google.com/patent/WO2009135049A1/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi&page=9 (Access on 2/04/2023). Google.
Available from: https://patents.google.com/patent/WO2010126794A1/en?q=(Trachyspermum+ammi)&oq=+Trachyspermum+ammi&page=9 (Access on 2/04/2023). Google.
Khanehzad M, Abolhasani F, Koruji SM, Ragerdi Kashani I, Aliakbari F. The roles of Sertoli cells in fate determinations of spermatogonial stem cells Medical Journal TUMS Publications. 2016 Mar 10;73(12):878-87.
Bettaieb Rebey IB, Jabri-Karoui I, Hamrouni-Sellami I, Bourgou S, Limam F, Marzouk B. Effect of drought on the biochemical composition and antioxidant activities of cumin (Cuminum cyminum L.) seeds. Ind Crops Prod. 2012 Mar 1;36(1):238-45. doi: 10.1016/j.indcrop.2011.09.013.
Wahab AT, Ilyas Q, Farooq S, Javaid S, Ahmed S, Rahman AU et al. In-vitro and in-vivo anticandidal activity of Trachyspermum Ammi (L.) Sprague seeds ethanolic extract and thymol-containing hexanes fraction. Nat Prod Res. 2021 Nov 18;35(22):4833-8. doi: 10.1080/14786419.2020.1731738, PMID 32233667.
Singh NP, Pandey VP, Chand Yadav G, Singh G, Tyagi N, Pandey P et al. Genetic divergence studies in ajwain (Trachyspermum Ammi L.) genotypes. Int J Curr Microbiol Appl Sci. 2017;6(11):563-9. doi: 10.20546/ijcmas.2017.611.068.
Ramchander PJ, Middha A. Recent advances on ajowan and its essential constituents. J Med Plants. 2017;5(3):16-22.
Moein MR, Zomorodian K, Pakshir K, Yavari F, Motamedi M, Zarshenas MM. Trachyspermum Ammi (L.) Sprague: chemical composition of essential oil and antimicrobial activities of respective fractions. J Evid Based Complementary Altern Med. 2015 Jan;20(1):50-6. doi: 10.1177/2156587214553302, PMID 25305209.
Mishra S. A review of super food ajwain and its pharmacological actions. Int J Res Pharm Pharm Sci. 2020;1(1):303.
Gaddamwar DAG, Rajput PR, Parsodkar VJ. Extraction of basil, Padina, ajwain and development of oxygen garden in the school yard as a preventive measure for Covid-19. IJRASET. 2020;8(6):1408-11. doi: 10.22214/ijraset.2020.6228.
Pal DK, Dutt B, Varun Attri RD. Studies on important medicinal plants of mid Himalayan region of Himachal Pradesh. Int J Pharm Innov. 2020;9:158-75.
Saleem U, Riaz S, Ahmad B, Saleem M. Pharmacological screening of Trachyspermum Ammi for antihyperlipidemic activity in Triton X-100 induced hyperlipidemia rat model. Pharmacogn Res. 2017 Dec;9;Suppl 1:S34-40. doi: 10.4103/pr.pr_37_17, PMID 29333040.
Attou A, Davenne D, Benmansour A, Lazouni HA. Chemical composition and biological activities of Ammoides verticillata essential oil from west Algeria. Phytothérapie. 2019 Feb 1;17(1):2-8. doi: 10.3166/phyto-2019-0116.
Kumar A, Singh AK. Trachyspermum Ammi (Ajwain): A Comprehensive Review. World J Pharm Res. 2021 Apr 5;10(6):724-36. doi: 10.20959/wjpr20216-20569.
Prakash C, Ansari SH, Kaur G, MP. I, ram N, Singh GD. Analytical method development and its validation for the estimationof thymol in tachyspermum ammi mill fruit by gas liquid chromatography. Available from: https://citeseerx.ist.psu.edu/document?repid=rep1&type=pdf&doi=cbfc6ef584849edf01b225ed2deab0cca7ffc287.
Gayathri T, Giridhar K, Tanuja Priya B, Paratpara Rao M, Vijaya Lakshmi T. Variation for qualitative traits in ajwain (Trachyspermum Ammi L.) germplasm. Available from: https://www.researchgate.net/profile/GiridharKalidasu/publication/365728191_Variation_for_Qualitative_Traits_in_Ajwain_Trachyspermum_ammi_L_Germplasm/links/63805717c2cb154d29248b64/Variation-for-Qualitative-Traits-in-Ajwain-Trachyspermum-ammi-L-Germplasm.pdf.
Asif HM, Sultana S, Akhtar N. A panoramic view on phytochemical, nutritional, ethanobotanical uses and pharmacological values of Trachyspermum Ammi Linn. Asian Pac J Trop Biomed. 2014 Jul 1;4:S545-53. doi: 10.12980/APJTB.4.2014APJTB-2014-0242.
Grover M. Ayurvedic significance of World’s ancient spice. Trachyspermum Ammi linn.(Ajwain). Available from: http://irjpms.com/wp-content/uploads/2021/07/IRJPMS-V4N4P100Y21.pdf.
Goyal S, Chaturvedi V, Dhingra G, Tanwar S, Sharma K, Singh S. Trachyspermum Ammi: a review on traditional and modern pharmacological aspects Traditional and modern aspects. J Biol Sci. 2022 Nov 8;02(4):324-37. doi: 10.55006/biolsciences.2022.2401.
Barimani F, Gholami AA, Nabili M. In vitro antifungal activity of Raphanus sativus L. var. niger (black radish) and Trachyspermum Ammi (ajwain) on resistant and susceptible Aspergillus fumigatus isolates. Int J Mol Clin Microbiol. 2020 Dec 1;10(2):1360-8.
Chauhan B, Kumar G, Ali M. Pharmacognostical and physiochemical parameters of Trachyspermum Ammi (L.) Sprague (fruits). Curr Res Pharm Sci. 2013 Sep 30;87-91.
Zargaran A, Zarshenas MM, Mehdizadeh A, Mohagheghzadeh A. Oxymel in medieval Persia. Pharm Hist (Lond). 2012;42(1):11-3. PMID 22530314.
Ishikawa T, Sega Y, Kitajima J. Water-soluble constituents of ajowan. Chem Pharm Bull (Tokyo). 2001;49(7):840-4. doi: 10.1248/cpb.49.840, PMID 11456088.
Choudhury S, Ahmed R, Kanjilal PB, Leclercq PA. Composition of the seed oil of Trachyspermum Ammi (L.) Sprague from Northeast India. J Essent Oil Res. 1998 Sep 1;10(5):588-90. doi: 10.1080/10412905.1998.9700979.
Hardel D, Sahoo L, Patel J. Pharmacognostic studies on Trachyspermum Ammi linn. A powder analysis. IJRAP. 2011;2(4):1272-7.
Katasani D, Srinu B, Bala R. Phytochemical screening, quantitative estimation of total phenolic, flavanoids and antimicrobial evaluation of Trachyspermum Ammi. J Atoms Mol. 2011;1(1):1-8.
Jeet K, Devi N, Narender T, Sunil T, Lalit S, Raneev T. Trachyspermum Ammi (ajwain): a comprehensive review. Int Res J Pharm. 2012 May;3(5):133-8.
Ishikawa T, Sega Y, Kitajima J. Water-soluble constituents of ajowan. Chem Pharmaceuticalbulletin. 2001;49(7):8404.
Beegam KS, Joseph A, Singh VPP. Evaluation of the antimicrobial efficacy of Elettaria cardamomum oil, Trachyspermum ammi Oil and 5% Sodium Hypochlorite Against Enterococcus faecalis Biofilm Formed on Tooth Substrate. Contemp Clin Dent. 2021 Oct;12(4):396-400. doi: 10.4103/ccd.ccd_643_20, PMID 35068839.
Hanif MA, Hassan SM, Mughal SS, Rehman A, Hassan SK, Ibrahim A et al. An overview on ajwain (Trachyspermum Ammi) pharmacological effects: current and conventional. Technology. 2021 Apr 30;5(1):1-6. doi: 10.11648/j.pst.20210501.11.
Anwar S, Ahmed N, Habibatni S, Abusamra Y. Ajwain (Trachyspermum Ammi L.) oils. Inessential oils in food preservation, flavor and safety 2016 Jan 1 (pp. 181-92). Academic Press. doi: 10.1016/B978-0-12-416641-7.00019-5.
Vitali LA, Beghelli D, Biapa Nya PC, Bistoni O, Cappellacci L, Damiano S et al. Diverse biological effects of the essential oil from Iranian Trachyspermum ammi. Arab J Chem. 2016 Nov 1;9(6):775-86. doi: 10.1016/j.arabjc.2015.06.002.
Goyal S, Chaturvedi V, Dhingra G, Tanwar S, Sharma K, Singh S. Trachyspermum Ammi: a review on traditional and modern pharmacological aspects. J Biol Sci. 2022 Nov 8;2(4):324-37.
Shuja S, Owais A, Fatima N, Shan M, Khan M, Zaman M. The Use, Phytochemical and antimicrobial Activity Evaluation of Foeniculum vulgare, Cuminum cyminum, and Trachyspermum Ammi Were Reviewed for the Treatment of Gastric Diseases as Future compounds. J Pharm Pharmacol. 2022;10:273-82. doi: 10.17265/2328-2150/2022.10.005.
Zarshenas MM, Moein M, Samani SM, Petramfar P. An overview on ajwain (Trachyspermum Ammi) pharmacological effects; modern and traditional. J Nat Rem. 2014:98-105.
Omidpanah S, Aliakbari F, Nabavi SM, Vazirian M, Hadjiakhoondi A, Kurepaz-Mahmoodabadi M et al. Effects of monoterpenes of Trachyspermum Ammi on the viability of spermatogonia stem cells in vitro. Plants (Basel). 2020;9(3):343. doi: 10.3390/plants9030343, PMID 32182777.
Baschieri A, Ajvazi MD, Tonfack JLF, Valgimigli L, Amorati R. Explaining the antioxidant activity of some common non-phenolic components of essential oils. Food Chem. 2017 Oct 1;232:656-63. doi: 10.1016/j.foodchem.2017.04.036, PMID 28490124.
Hsu SS, Lin KL, Chou CT, Chiang AJ, Liang WZ, Chang HT et al. Effect of thymol on Ca2+ homeostasis and viability in human glioblastoma cells. Eur J Pharmacol. 2011 Nov 16;670(1):85-91. doi: 10.1016/j.ejphar.2011.08.017, PMID 21914442.
Sharifzadeh A, Shokri H. Antifungal activity of essential oils from Iranian plants against fluconazole-resistant and fluconazole-susceptible Candida albicans. Avicenna J Phytomed. 2016 Mar;6(2):215-22. doi: 10.1093/jas/skad047, PMID 27222835.
Escobar A, Pérez M, Romanelli G, Blustein G. Thymol bioactivity: a review focusing on practical applications. Arab J Chem. 2020 Dec 1;13(12):9243-69. doi: 10.1016/j.arabjc.2020.11.009.
Akber M, Seraj S, Islam F, Ferdausi D, Ahmed R, Nasrin D et al. A survey of medicinal plants used by the traditional medicinal practitioners of Khulna City, Bangladesh. Am Eurasian J Sustain Agric. 2011 Apr 1;5:177-95.
Debjit Bhowmik C, Kumar KS, Chandira M, Jayakar B. Turmeric: a herbal and traditional medicine. Arch Appl Sci Res. 2009;1(2):86-108.
Ravisankar P, Koushik O, Reddy A, Kumar U. AP, Pragna P. A detailed analysis on acidity and ulcers in esophagus, gastric and duodenal ulcers and management. IOSR JDMS (IOSR-JDMS). 2016;15(1):94-114. doi: 10.9790/0853-1511094114.
Razzak DMA. Pharmacological and phytochemical profile of Trachyspermum Ammi: evidence from the traditional medicine and recent research. Int J Unani Integ Med. 2020;4(3):19-23. doi: 10.33545/2616454X.2020.v4.i3a.139.
Williams C. Medicinal plants in Australia volume 4: an Antipodean apothecary. Rosenberg publishing; 2013 May 1. Google. Available from: https://books.google.com/books?hl=en&lr=&id=7eVUAQAAQBAJ&oi=fnd&pg=PA5&dq=Williams+C.+Medicinal+plants+in+Australia+volume+4:+an+Antipodean+apothecary.+Rosenberg+Publishing%3B+2013+May+1.&ots=O71yEGbnvz&sig=uui7We0nANR6-mu4WQ5sr9tDobM.
Singh H. Meghwal M. Ajwain a potential source of phytochemical for better health. J Pharm Innov. 2019;8:599-603.
Awan SJ, Hadi F, Maqbool T, Nadeem S, Malik S, Farzand A. A review on the medicinal potential of Trachyspermum Ammi Found in Pakistan. JPRI:302-11. doi: 10.9734/jpri/2021/v33i41B32369.
Ladani MR. Brief review on analgesic and anti-inflammatory properties of Moringa oleifera, Senna auriculata & other useful medicinal plants to inhibit release of immune mediators. Available from: https://www.researchgate.net/profile/Miral-Ladani-3/publication/363187025_Brief_review_on_analgesic_and_anti-inflammatory_properties_of_Moringa_oleifera_Senna_auriculata_other_useful_medicinal_plants_to_inhibit_release_of_immune_mediators/links/6310e1651ddd4470212885bc/Brief-review-on-analgesic-and-anti-inflammatory-properties-of-Moringa-oleifera-Senna-auriculata-other-useful-medicinal-plants-to-inhibit-release-of-immune-mediators.pdf?_sg%5B0%5D=started_experiment_milestone&origin=journalDetail&_rtd=e30%3D.
Rajeshwari CU, Kumar AV, Andallu B. Therapeutic potential of ajwain [Tracyspermum ammi L] Seeds. InNuts and seeds in health and disease prevention 2011 Jan 1 (pp. 153-9). Academic Press. doi: 10.1016/B978-0-12-375688-6.10017-9.
Available from: https://www.google.com/aclk?sa=l&ai=DChcSEwi_65fao4P-AhUWDisKHTJ0C6EYABAFGgJzZg&sig=AOD64_2mnnZ6jKOeAFJ1FT3G7UuUSf8o8g&adurl&ctype=5&ved=2ahUKEwiN0Y3ao4P-AhURkOYKHWWXDCYQvhd6BAgBEFA (Access on 30/03/2023). Google.
Available from: https://www.google.com/aclk?sa=l&ai=DChcSEwi_65fao4P-AhUWDisKHTJ0C6EYABABGgJzZg&sig=AOD64_3UpIKznj5nGfQb6KhnA448CfrmAw&adurl&ctype=5&ved=2ahUKEwiN0Y3ao4P-AhURkOYKHWWXDCYQvhd6BAgBEEY (Access on 30/03/2023). Google.
Available from: https://brijbooti.in/?ixwpse=1&rating=3&taxonomy=product_shipping_class&term=below-500 (Access on 30/03/2023).
Available from: https://www.athreyaherbs.com/products/hingvastak-powder(Access on 30/03/2023).
Al-Snafi AE. Therapeutic importance of Hyoscyamus species grown in Iraq (Hyoscyamus albus, Hyoscyamus niger and Hyoscyamus reticulates)-A review. IOSR J Pharm. 2018;8(6):18-32.
Dehdari S, Hajimehdipoor H. Medicinal properties of Adiantum capillus-veneris Linn. in traditional medicine and modern phytotherapy: a review article. Iran J Public Health. 2018 Feb;47(2):188-97. PMID 29445628.
Petramfar P, Moein M, Samani SM, Tabatabaei SH, Zarshenas MM. Trachyspermum Ammi 10% topical cream versus placebo on neuropathic pain, a randomized, double-blind, placebo-controlled trial. Neurol Sci. 2016 Sep;37(9):1449-55. doi: 10.1007/s10072-016-2600-3, PMID 27166709.
Dubey S. Kashyap P. Trachyspermum Ammi: a review on its multidimensional uses in Indian folklore medicines. Res J Med Plants. 2015;9(8):368-74. doi: 10.3923/rjmp.2015.368.37410.3923/rjmp.2015.368.374.
Sharifzadeh A, Khosravi AR, Shokri H, Sharafi G. Antifungal effect of Trachyspermum Ammi against susceptible and fluconazole-resistant strains of Candida albicans. J Mycol Med. 2015 Jun 1;25(2):143-50. doi: 10.1016/j.mycmed.2015.03.008, PMID 25982599.
Mazzara E, Scortichini S, Fiorini D, Maggi F, Petrelli R, Cappellacci L et al. A design of experiment (DoE) approach to model the yield and chemical composition of ajowan (Trachyspermum Ammi L.) essential oil obtained by microwave-assisted extraction. Pharmaceuticals (Basel). 2021 Aug 19;14(8):816. doi: 10.3390/ph14080816, PMID 34451913.
Nickavar B, Adeli A, Nickavar A. TLC-bioautography and GC-MS analyses for detection and identification of antioxidant constituents of Trachyspermum copticum essential oil. Iran J Pharm Res. 2014;13(1):127-33. PMID 24734063.
Bora L. Anticandidal activity of medicinal plants and Pseudomonas aeruginosa strains of clinical specimens. J Microbiol Immunol Infect. 2016 Apr 1;49(2):276-80. doi: 10.1016/j.jmii.2014.10.002, PMID 25592881.
Yazdeli MZ, Ghazaei C, Maraghi ET, Bakhshi A, Shukohifar M. Evaluation of antibacterial Synergism of methanolic Extract of Dracocephalum kotschyi and Trachyspermum Ammi. Malays J Med Sci MJMS. 2021 Dec;28(6):64-75. doi: 10.21315%2Fmjms2021.28.6.7.
Clinical and Laboratory Standards Institute. Performance standards for antimicrobial susceptibility testing; twenty-first informational supplement; CLSI document M100. 2017-S21. doi: 10.11150/kansenshogakuzasshi.85.355.
Qamar N, John P, Bhatti A. Toxicological and Anti-rheumatic potential of Trachyspermum Ammi derived biogenic selenium nanoparticles in arthritic BALB/c mice. Int J Nanomedicine. 2020 May 15;15:3497-509. doi: 10.2147/IJN.S243718, PMID 32547009.
Chaubey MK. Study of insecticidal properties of Trachyspermum Ammi and Mentha arvensis essential oils against Sitophilus zeamais L.(Coleoptera: Curculionidae). Curr Life Sci. 2018 Jan;4:10-7. doi: 10.5281/zenodo.1116380.
Sharifi Mood BS, Shafeghat M, Metanat M, Saeidi S, Sepehri N. The inhibitory effect of ajowan essential oil on bacterial growth. Int J Infect. 2014 Jul 30;1(2). doi: 10.17795/iji-19394.
Siddiqui MJ, Aslam A, Khan T. Comparison and evaluation of different seed extracts of Trachyspermum Ammi for immunomodulatory effect on cell-mediated immunity through delayed-type hypersensitivity assay skin thickness method. J Pharm Bioallied Sci. 2019 Jan;11(1):43-8. doi: 10.4103/jpbs.JPBS_174_18, PMID 30906139.
Rai M, Rathod D, Agarkar G, Dar M, Brestic M, Pastore GM et al. Fungal growth promotor endophytes: a pragmatic approach towards sustainable food and agriculture. Symbiosis. 2014 Feb;62(2):63-79. doi: 10.1007/s13199-014-0273-3.
Andrés MF, Diaz CE, Giménez C, Cabrera R, González-Coloma A. Endophytic fungi as novel sources of biopesticides: the Macaronesian Laurel forest, a case study. Phytochem Rev. 2017 Oct;16(5):1009-22. doi: 10.1007/s11101-017-9514-4. Rai M, Rathod D, Agarkar G, Dar M, Brestic M, Pastore GM et al. Fungal growth promotor endophytes: a pragmatic approach towards sustainable food and agriculture. Symbiosis. 2014 Feb;62(2):63-79. doi: 10.1007/s13199-014-0273-3.
Maggiore M, Pensel PE, Denegri G, Elissondo MC. Chemoprophylactic and therapeutic efficacy of thymol in murine cystic echinococcosis. Parasitol Int. 2015 Oct 1;64(5):435-40. doi: 10.1016/j.parint.2015.06.005, PMID 26096310.
Zhou LH, Jiang YK, Li RY, Huang LP, Yip CW, Denning DW et al. Risk-based estimate of human fungal disease burden, China. Emerg Infect Dis. 2020 Sep;26(9):2137-47. doi: 10.3201/eid2609.200016, PMID 32818410.
Iannarelli R, Marinelli O, Morelli MB, Santoni G, Amantini C, Nabissi M et al. Aniseed (Pimpinella anisum L.) essential oil reduces pro-inflammatory cytokines and stimulates mucus secretion in primary airway bronchial and tracheal epithelial cell lines. Ind Crops Prod. 2018 Apr 1;114:81-6. doi: 10.1016/j.indcrop.2018.01.076.
Boskabady MH, Alitaneh S, Alavinezhad A. Carum copticum L.: a herbal medicine with various pharmacological effects. BioMed Res Int. 2014 Jun 25;2014:569087. doi: 10.1155/2014/569087, PMID 25089273.
Dutta P, Sarma N, Saikia S, Gogoi R, Begum T, Lal M. Pharmacological activity of Trachyspermum Ammi L. seeds essential oil grown from Northeast India. J Essent Oil Bear Plants. 2021 Nov 2;24(6):1373-88. doi: 10.1080/0972060X.2022.2028681.
Sargazi Zadeh G, Panahi N. Endothelium-independent vasorelaxant activity of Trachyspermum Ammi essential oil on rat aorta. Clin Exp Hypertens. 2017 Feb 17;39(2):133-8. doi: 10.1080/10641963.2016.1235178, PMID 28287882.
Vegad UG, Pandya DJ. Tackling COVID-19 through Ayurveda: a review on the herbs of recommended Indian remedies. Curr Trad Med. 2021 Oct 1;7(5):15-32. doi: 10.2174/2215083807666210210152256.
Jyoti D, Dheer D, Singh D, Kumar G, Karnatak M, Chandra S et al. Thymol chemistry: A medicinal toolbox. Curr Bioact Compd. 2019 Oct 1;15(5):454-74. doi: 10.2174/1573407214666180503120222.
Rao FV, Andersen OA, Vora KA, DeMartino JA, Van Aalten DM. Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes. Chem Biol. 2005 Sep 1;12(9):973-80. doi: 10.1016/j.chembiol.2005.07.009, PMID 16183021.
Wadhwa M, Bakshi MPS. Effect of supplementing total mixed ration with ajwain (Trachyspermum Ammi) oil on the performance of buffalo calves. Indian J Ani Sci. 2019 Apr 1;89(4):424-30. doi: 10.56093/ijans.v89i4.89144.
Jimmy A. Characterization of Physalis lagascae for its in vitro anticancer activity (Doctoral dissertation, Annai JKK Sampoorani Ammal College of Pharmacy, Komarapalayam). Available from: http://repository-tnmgrmu.ac.in/id/eprint/10636.
Basu S, Banik BK. Natural spices in medicinal chemistry: properties and benefits. InGreen approaches in medicinal chemistry for sustainable drug design 2020 Jan 1 (pp. 739-58). Elsevier. doi: 10.1016/B978-0-12-817592-7.00022-8.
Khan N, Jamila N, Ejaz R, Nishan U, Kim KS. Volatile oil, phytochemical, and biological activities evaluation of Trachyspermum Ammi seeds by chromatographic and spectroscopic methods. Anal Lett. 2020 Apr 12;53(6):984-1001. doi: 10.1080/00032719.2019.1688825.
Singh PA, Bajwa N, Chinnam S, Chandan A, Baldi A. An overview of some important deliberations to promote medicinal plants cultivation. J Appl Res Med Aromat Plants. 2022 May 25;31:100400. doi: 10.1016/j.jarmap.2022.100400.
Soni K, Parle M. Trachyspermum Ammi seeds supplementation helps reverse scopolamine, alprazolam and electroshock induced amnesia. Neurochem Res. 2017 May;42(5):1333-44. doi: 10.1007/s11064-017-2177-0, PMID 28097466.
Anilakumar KR, Saritha V, Khanum F, Bawa AS. Ameliorative effect of ajwain extract on hexachlorocyclohexane-induced lipid peroxidation in rat liver. Food Chem Toxicol. 2009 Feb 1;47(2):279-82. doi: 10.1016/j.fct.2008.09.061, PMID 18940228.
Shahrajabian MH, Sun W, Cheng Q. Pharmaceutical benefits and multidimensional uses of ajwain (Trachyspermum Ammi L.). Pharmacogn Commun. 2021 Apr 1;11(2):138-41. doi: 10.5530/pc.2021.2.25.
Subrata B. Ajwain and its phenolic compound, carvacrol improve cadmium-induced apoptosis in PC12 cells [doctoral dissertation]. doi: 10.14943/doctoral.k13888.
Mahmoudpour Z, Shokri J, Kamalinejad M, Meftah N, Khafri S, Mozaffarpur SA et al. The efficacy of a Persian herbal formulation on functional bloating: A double-blind randomized controlled trial. J Integr Med. 2019 Sep 1;17(5):344-50. doi: 10.1016/j.joim.2019.05.007, PMID 31201146.
Korani M, Jamshidi M. The effect of aqueous extract of Trachyspermum Ammi seeds and ibuprofen on inflammatory gene expression in the cartilage tissue of rats with collagen-induced arthritis. J Inflam Res. 2020 Feb 28;13:133-9. doi: 10.2147/JIR.S236242, PMID 32184646.
Sasikumar JM, Erba O, Egigu MC. In vitro antioxidant activity and polyphenolic content of commonly used spices from Ethiopia. Heliyon. 2020 Sep 1;6(9):e05027. doi: 10.1016/j.heliyon.2020.e05027, PMID 32995654.
Daga P, Vaishnav SR, Dalmia A, Tumaney AW. Extraction, fatty acid profile, phytochemical composition and antioxidant activities of fixed oils from spices belonging to Apiaceae and Lamiaceae family. J Food Sci Technol. 2022;59(2):518-31. doi: 10.1007/s13197-021-05036-1, PMID 35185173.
Grădinaru AC, Trifan A, Şpac A, Brebu M, Miron A, Aprotosoaie AC. Antibacterial activity of traditional spices against lower respiratory tract pathogens: combinatorial effects of Trachyspermum Ammi essential oil with conventional antibiotics. Lett Appl Microbiol. 2018 Nov 1;67(5):449-57. doi: 10.1111/lam.13069, PMID 30187508.
Hassanshahian M, Bayat Z, Saeidi S, Shiri Y. Antimicrobial activity of Trachyspermum Ammi essential oil against human bacterial. Available from: https://www.sid.ir/en/VEWSSID/J_pdf/57000020140102.pdf.
Naquvi KJ, Ansari SH, Salma A, Ahamad J, Najib S. A review on phytochemical investigations and biological activities of Trachyspermum Ammi (L.) Sprague. Res J Pharm Technol. 2022 May 1;15(5):2364-70.
Ali A. Herbs that heal: the philanthropic behavior of nature. Ann Phytomed. 2020;9(1):7-17. doi: 10.21276/ap.2020.9.1.2.
Bhadra P. An overview of ajwain (Trachyspermum Ammi). Indian J Nat Sci. 2020;10(59):18466-2474.
Saraswat S, Kharche SD, Jindal SK. Impact of reactive oxygen species on spermatozoa: ABalancing act between beneficial and detrimental effects. Iran J Appl Anim Sci. 2014 Mar 1;4(2):247-55.
Nagoor Meeran MF, Javed H, Al Taee H, Azimullah S, Ojha SK. Pharmacological properties and molecular mechanisms of thymol: prospects for its therapeutic potential and pharmaceutical development. Front Pharmacol. 2017 Jun 26;8:380. doi: 10.3389/fphar.2017.00380, PMID 28694777.
Llana-Ruiz-Cabello M, Gutiérrez-Praena D, Puerto M, Pichardo S, Jos Á, Cameán AM. In vitro pro-oxidant/antioxidant role of carvacrol, thymol and their mixture in the intestinal Caco-2 cell line. Toxicol In Vitro. 2015 Jun 1;29(4):647-56. doi: 10.1016/j.tiv.2015.02.006, PMID 25708581.
Sachan N, Saraswat N, Chandra P, Khalid M, Kabra A. Isolation of thymol from Trachyspermum Ammi Fruits for treatment of diabetes and diabetic neuropathy in STZ-induced rats. BioMed Res Int. 2022 Apr 28;2022:8263999. doi: 10.1155/2022/8263999, PMID 35528161.
Paul S, Kang SC. In vitro determination of the contraceptive spermicidal activity of essential oil of Trachyspermum Ammi (L.) Sprague ex Turrill fruits. New Biotechnol. 2011 Oct 1;28(6):684-90. https://doi:10.1016/j.nbt.2011.02.008. doi: 10.1016/j.nbt.2011.02.008, PMID 21396489.
Platel K, Srinivasan K. Studies on the influence of dietary spices on food transit time in experimental rats. Nutr Res. 2001 Sep 1;21(9):1309-14. doi: 10.1016/S0271-5317(01)00331-1.
Solanki ND, Bhavsar SK. An evaluation of the protective role of Ficus racemosa Linn. in streptozotocin-induced diabetic neuropathy with neurodegeneration. Indian J Pharmacol. 2015 Nov;47(6):610-5. doi: 10.4103/0253-7613.169579, PMID 26729951.
Abtahi MS, Maghsoudi H, Hatef B, Marashi P, Vassaf M. Antifungal effect of flavonoid extract of Trachyspermum Ammi plant on the gene expression of pro-inflammatory cytokines such as IL-18 and TNF-α? in articular THP-1 monocyte/Macrophages Cells. Biosci Biotechnol Res Asia. 2015;12(2):1339-44. doi: 10.13005/bbra/1789.
Modareskia M, Fattahi M, Mirjalili MH. Thymol screening, phenolic contents, antioxidant and antibacterial activities of Iranian populations of Trachyspermum Ammi (L.) Sprague (Apiaceae). Sci Rep. 2022 Sep 19;12(1):15645. doi: 10.1038/s41598-022-19594-7, PMID 36123425.
Aslam A, Nokhala A, Peerzada S, Ahmed S, Khan T, Siddiqui MJ. Evaluation and comparison of Trachyspermum Ammi seed extract for its anti-inflammatory effect. J Pharm Bioallied Sci. 2020 Nov;12;Suppl 2:S777-80. doi: 10.4103/jpbs.JPBS_243_19, PMID 33828377.
Arasu A, Pingley V, Prabha N, O R, Annathurai K, Kasirajan S et al. Impact and fungitoxic spectrum of Trachyspermum Ammi against Candida albicans, an opportunistic pathogenic fungus commonly found in human gut that causes candidiasis infection. J Infect Public Health. 2021 Dec 1;14(12):1854-63. doi: 10.1016/j.jiph.2021.09.027, PMID 34656507.
Kaur J, Kaur R, Datta R, Kaur S, Kaur A. Exploration of insecticidal potential of an alpha glucosidase enzyme inhibitor from an endophytic Exophiala spinifera. J Appl Microbiol. 2018 Nov 1;125(5):1455-65. doi: 10.1111/jam.13947, PMID 29877011. Kaur J, Kaur R, Datta R, Kaur S, Kaur A. Exploration of insecticidal potential of an alpha glucosidase enzyme inhibitor from an endophytic Exophiala spinifera. J Appl Microbiol. 2018 Nov 1;125(5):1455-65. doi: 10.1111/jam.13947, PMID 29877011.
Bajpai VK, Agrawal P. Studies on phytochemicals, antioxidant, free radical scavenging and lipid peroxidation inhibitory effects of Trachyspermum Ammi seeds. Indian J Pharm Educ Res. 2015 Jan 1;49(1):58-65, doi: 10.5530/ijper.49.1.8.
Yu YM, Chao TY, Chang WC, Chang MJ, Lee MF. Thymol reduces oxidative stress, aortic intimal thickening, and inflammation-related gene expression in hyperlipidemic rabbits. J Food Drug Anal. 2016 Jul 1;24(3):556-63. doi: 10.1016/j.jfda.2016.02.004, PMID 28911561.
Lee SC, Seo SM, Huh MJ, Kwon JH, Nam I, Park JH et al. Behavioral and electrophysiological effects of ajowan (Trachyspermum Ammi Sprague)(Apiales: Apiaceae) essential oil and its constituents on nymphal and adult bean bugs, Riptortus clavatus (Thunberg)(Hemiptera: Alydidae). Insects. 2020 Feb 4;11(2):104. doi: 10.3390/insects11020104, PMID 32033226.
Chandrasekar R, Chandrasekar S. Natural herbal treatment for rheumatoid arthritis-a review. Int J Pharm Sci Res. 2017 Feb 1;8(2):368. doi: 10.13040/IJPSR.0975-8232.8.
Perera WPRT, Liyanage JA, Dissanayake KGC, Gunathilaka H, Weerakoon WMTDN, Wanigasekara DN et al. Antiviral potential of selected medicinal herbs and their isolated natural products. BioMed Res Int. 2021 Dec 8;2021:7872406. doi: 10.1155/2021/7872406, PMID 34926691.
Roy S, Chaurvedi P, Chowdhary A. Evaluation of antiviral activity of essential oil of Trachyspermum Ammi against Japanese encephalitis virus. Pharmacogn Res. 2015 Jul;7(3):263-7. doi: 10.4103/0974-8490.157977, PMID 26130938.
Hosseinkhani F, Jabalameli F, Banar M, Abdellahi N, Taherikalani M, Leeuwen WB et al. Monoterpene isolated from the essential oil of Trachyspermum Ammi is cytotoxic to multidrug-resistant Pseudomonas aeruginosa and Staphylococcus aureus strains. Rev Soc Bras Med Trop. 2016 Mar;49(2):172-6. doi: 10.1590/0037-8682-0329-2015, PMID 27192585.
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