Evaluation of Physico-Phytochemical Parameters of Holarrhena Pubescens Wall.Ex G. Don. (Kutaja) Seed and Bark and Their Effect in Obesity Associated Hyperlipidemia

Pharmaceutical Science-Pharmacology

Authors

  • Rajkumar Gupta Department of Dravyaguna, Mahatma Gandhi Ayurved College, Hospital& Research Centre, Dattameghe Institute of Higher Education and Research Deemed to be University, Sawangi(M), Wardha. India
  • Ombeer Pal Department of Dravyaguna, Mahatma Gandhi Ayurved College, Hospital& Research Centre, Dattameghe Institute of Higher Education and Research Deemed to be University, Sawangi(M), Wardha. India
  • Shraddha Nayak Department of Dravyaguna, School of Ayurveda, D. Y. Patil Deemed to be University, Nerul, Navi Mumbai, Maharashtra, India https://orcid.org/0000-0002-5266-2685
  • Mohan Yende Department of Rachana sharirbhausaheb mulakayurved College Nagpur, India
  • Ritu Wadhwa Department of Panchakarma and Kayachikitsa, School of Ayurveda, D. Y. Patil Deemed to be University, Nerul, Navi Mumbai, Maharashtra, India
  • Arundhati Banerje School of Biotechnology and Bioinformatics, D. Y. Patil Deemed to Be University, Plot No 50, Sector-15, CBD Belapur, Navi Mumbai-400614, Maharashtra, India
  • Kanchanlata Tungare School of Biotechnology and Bioinformatics, D. Y. Patil Deemed to Be University, Plot No 50, Sector-15, CBD Belapur, Navi Mumbai-400614, Maharashtra, India
  • Mustansir Bhori School of Biotechnology and Bioinformatics, D. Y. Patil Deemed to Be University, Plot No 50, Sector-15, CBD Belapur, Navi Mumbai-400614, Maharashtra, India
  • Shishira Bharadwaj Loma Linda University Medical Center, CA, USA
  • Dnyaneshwar Padvi Department of Panchakarma and Kayachikitsa, School of Ayurveda, D. Y. Patil Deemed to be University, Nerul, Navi Mumbai, Maharashtra, India

DOI:

https://doi.org/10.22376/ijlpr.2023.13.5.P14-P24

Keywords:

Hyperlipidemia, Obesity, Kutaja (Holarrhenapubescens Wall. ex G. Don), Cholesterol, Triglyceride, Physico-chemical, Phytochemical analysis.

Abstract

Obesity-related Hyperlipidemia is a major health concern due to its strong association with a number of diseases like diabetes, ischemic heart disease,and renal disease. The safe treatment of Hyperlipidemia thus becomes the need of the hour. This study aimed to evaluate the pharmacognostic, physicochemical,with phytochemical properties of Holarrhenapubescens Wall.ex G. Don. (Kutaja) seed and bark. The pharmacognostic, physicochemical, and phytochemical evaluationof collected samples of H. pubescens seeds and bark was performed and was found to be as per API norms. Furthermore, to evaluate and compare their efficacyin the treatment of Hyperlipidemia. - Forty subjects were randomly allocated to two groups according to the plant part administered to them and was observedfor 90 days. The assessment was done on the basis of subjective parameters (Laziness, heaviness of body, Shortness of breath, and sleepiness) and objectiveparameters (total cholesterol, triglycerides, LDL, HDL, VLDL, and total Cholesterol to HDL ratio) before and after the treatment duration. - Significant decreasein the subjective parameters was recorded, and similarly, a significant decrease in the levels of total cholesterol, LDL, VLDL, and total Cholesterol to HDL ratiowas observed for both the seed and the bark of Kutaja – The therapeutic effect of both the parts i.e. Kutaja seeds and bark were found at par in controllingHyperlipidemia and thus proved their definite role in ameliorating Medodustii.e. deranged lipid metabolism common in Obesity.– Both seeds and bark can be utilizedseparately and also in place of one another in cases of Obesity associated Hyperlipidemia.

References

Chandra KS, Bansal M, Nair T, Iyengar SS, Gupta R, Manchanda SC, et al. Consensus statement on management of Dyslipidemia in Indian subjects. Indian Heart J. 2014;66; Suppl 3:S1-51. doi 10.1016/j.ihj.2014.12.001, PMID 25595144.

Misra A, Luthra K, Vikram NK. Dyslipidemia in Asian Indians: determinants and significance. J Assoc Physicians India. 2004;52:137-42. PMID 15656049.

Geldsetzer P, Manne-Goehler J, Theilmann M, Davies JI, Awasthi A, Vollmer S et al. Diabetes and hypertension in India: a Nationally Representative Study of 1.3 Million Adults. JAMA Intern Med. 2018;178(3):363-72. doi: 10.1001/jamainternmed.2017.8094, PMID 29379964.

Joshi P, Islam S, Pais P, Reddy S, Dorairaj P, Kazmi K et al. Risk factors for early myocardial infarction in South Asians compared with individuals in other countries. JAMA. 2007;297(3):286-94. doi 10.1001/jama.297.3.286, PMID 17227980.

Sharma M, Ganguly NK. Premature coronary artery disease in Indians and its associated risk factors. Vasc Health Risk Manag. 2005;1(3):217-25. PMID 17319107.

Pahan K. Lipid-lowering drugs. Cell Mol Life Sci. 2006;63(10):1165-78. doi: 10.1007/s00018-005-5406-7, PMID 16568248.

Bansal AB, Cassagnol M. HMG-CoA Reductase Inhibitors. StatPearls. Stat. 2021.

Gyawali D, Schneider RH, Orme‐Johnson DW, Ramaratnam S. Ayurvedic herbal preparations for hypercholesterolemia. Cochrane Database Syst Rev. 2019 Mar 15;2019(3): CD012076.

Pal A, Sharma PP, Mukherjee PK. A clinical study of kutaja (HolarrhenaAntidysenterica wall) on Shonitarsha. AYU (An Int Q J Res Ayurveda). 2009;30(4):369.

Zahara K, Panda SK, Swain SS, Luyten W. Metabolic diversity and therapeutic potential of Holarrhena pubescens: an important ethnomedicinal plant. Biomolecules. 2020;10(9):1341. doi: 10.3390/biom10091341, PMID 32962166.

Ali K, Chatterjee K, De D, Bera T, Ghosh D. Efficacy of aqueous extract of seed of Holarrhenaantidysenterica for the management of diabetes in the experimental model rat: A correlative study with antihyperlipidemic activity. Int J Appl Res Nat Prod. 2009;2(3):13-21.

Panda A, Dixit AK. Effect of Indrayava (Holarrhenaantidysenterica seed) on inpatient uncomplicated severe hyperglycemia: A case study. J HomeopathyAyurvedic. Med. 2013 Jan 1;02.

Roghini R, Vijayalakshmi K. Phytochemical screening, quantitative analysis of flavonoids and minerals in ethanolic extract of Citrus paradisi. Int J Pharm Sci Res. 2018:4859-64.

Jadhav R, Shraddha N. Comparative phytochemical study of shalaparni and shalaparniksheerapaka. World J Pharm Res. 2019;8(12):1608-27.

Shaikh JR, Patil M. Qualitative tests for preliminary phytochemical screening: an overview. Int J Chem Stud. 2020;8(2):603-8. doi: 10.22271/chemi.2020.v8.i2i.8834.

Jain K, Khare S, Tabsum S. Macroscopic and microscopic evaluation of Abrusprecatorius L. (Gunja). Int J Pharm Sci Res. 2016:2631-5.

Vaidya. Review of KaphajNanatmajVyadhi with special reference to insulin resistance syndrome. World J Pharm Res. 2016;6(2):337-56.

Selvam ABD. Can the term Phytosensology be preferred over the term Organoleptic? Pharmacognosy Res. 2010;2(4):271-2. doi: 10.4103/0974-8490.69131, PMID 21808581.

Grover N, Meena R, Patni V. Physiochemical evaluation, phytochemical screening AndChromato-graphic fingerprint profile of WoodfordiaFruticosa (L.) Kurz extracts. Soc PharmSci Res. 2014 Jul 1;12(10):2772-82.

Vermani A, Chauhan A. Physico-chemical analysis of Ash of some medicinal plants growing in Uttarakhand, India. Nat Sci. 2010 Jan 1;8.

Shukla RK, Painuly D, Shukla A, Kumar V, Singh J, Porval A, et al. Physical evaluation, proximate analysis, and antimicrobial activity of MorusNigra seeds. Int J Pharm Pharm Sci. 2015 Jan 1:191-7.

Ajazuddin, Saraf S. Evaluation of physicochemical and phytochemical properties of Safoof-E-Sana, an Unani polyherbal formulation. Pharmacognosy Res. 2010;2(5):318-22. doi: 10.4103/0974-8490.72332, PMID 21589760.

A REVIEW OF Chung KT, Wong TY, Wei CI, Huang YW, Lin Y. Tannins and human health. Crit Rev Food Sci Nutr. 1998;38(6):421-64. doi: 10.1080/10408699891274273, PMID 9759559.

Lin D, Xiao M, Zhao J, Li Z, Xing B, Li X et al. An overview of plant phenolic compounds and their importance in human nutrition and managing Type 2 diabetes. Molecules. 2016;21(10):1374. doi: 10.3390/molecules21101374, PMID 27754463.

Ruiz‐Cruz S, Gassos Ortega LE, Mata MAL, Ornelas‐Paz Jde J, Chaparro‐Hernández S, Ruiz KLH, et al. Flavonoids: important bio compounds in food; 2017 Aug 23.

Shi J, Arunasalam K, Yeung D, Kakuda Y, Mittal G, Jiang Y. Saponins from edible legumes: chemistry, processing, and health benefits. J Med Food. 2004;7(1):67-78. doi: 10.1089/109662004322984734, PMID 15117556.

Attimarad M, Ahmed KKM, Aldhubaib BE, Harsha S. High-performance thin layer chromatography: A powerful analytical technique in pharmaceutical drug discovery. Pharm Methods. 2011;2(2):71-5. doi: 10.4103/2229-4708.84436, PMID 23781433.

Jahangeer C, Heenaye-Mamode Khan M, Mamode Khan N, Jahangeer S. The effect of risk factors on cardiovascular vascular diseases in Mauritius. Am Med J. 2010;1(1):46-50. doi: 10.3844/amjsp.2010.46.50.

Assadi SN. How do psychological stress and physical work affect blood lipid profiles? Medicine. 2017;96(18):e6816. doi 10.1097/MD.0000000000006816, PMID 28471984.

Nam JY, Kim J, Cho KH, Choi Y, Choi J, Shin J, et al. Associations of sitting time and occupation with metabolic syndrome in South Korean adults: A cross-sectional study. BMC Public Health. 2016;16(1):943. doi: 10.1186/s12889-016-3617-5, PMID 27605021.

Grundy SM. Overnutrition, ectopic lipid, and metabolic syndrome. J Investig Med. 2016;64(6):1082-6. doi: 10.1136/jim-2016-000155, PMID 27194746.

Kreuser F, Kromeyer-Hauschild K, Gollhofer A, Korsten-Reck U, Röttger K. ’Obese equals lazy?’ analysis of the association between weight status and physical activity in children. J Obes. 2013;2013:437017. doi: 10.1155/2013/437017, PMID 23533723.

Hashmi MF, Modi P, Sharma S. Dyspnea. StatPearls. StatPearlsPublishing. 2021.

Briones B, Adams N, Strauss M, Rosenberg C, Whalen C, Carskadon M et al. Relationship between sleepiness and general health status. Sleep. 1996;19(7):583-8. doi: 10.1093/sleep/19.7.583, PMID 8899938.

Sharma S, Bhattad S. Effect of vamanakarma with Kutajaeej yoga in managing Medorogaw. s.r. to Dyslipidemia Clinical study.Journal of Ayurved.Vol. 2017;4(Oct-Dec):51-6.

Nelson RH. Hyperlipidemia is a risk factor for cardiovascular disease. Prim Care. 2013;40(1):195-211. doi 10.1016/j.pop.2012.11.003, PMID 23402469.

Penumarthy S, Penmetsa GS, Mannem S. Assessment of serum levels of triglycerides, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol in periodontitis patients. J Indian Soc Periodontol. 2013;17(1):30-5. doi: 10.4103/0972-124X.107471, PMID 23633769.

GBD 2019 Diseases and Injuries CollaboratorsAbd-Allah, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: A systematic analysis for the global burden of disease Study 2019. Lancet. Oct 17, 2020;396(10258):1204-22. doi: 10.1016/S0140-6736(20)30925-9, PMID 33069326.

Abbafati C, Abbas KM, Abbasi M, MitraAbbasifard MohsenA-K, HedayatAbbastabar FAbd-Allah, et al. Five Insights from the global burden of disease Study 2019. Lancet. Oct 17, 2020;396(10258):1135-59. doi: 10.1016/S0140-6736(20)31404-5, PMID 33069324.

Franklin RC, Peden AE, Hamilton EB, Bisignano C, Castle CD, Dingels ZV et al. The burden of unintentional drowning: global, regional and national mortality estimates from the Global Burden of Disease 2017 Study. Inj Prev. 2020;26;Suppl 1:i83-95. doi 10.1136/injury prev-2019-043484. PMID 32079663.

Venugopal SK, Anoruo M, Jialal I. Biochemistry, low-density lipoprotein. StatPearls. 2021.

Published

2023-09-01

How to Cite

Gupta, R., Pal, O. ., Nayak, S. ., Yende, M. ., Wadhwa, R., Banerje, A. ., Tungare, K. ., Bhori, M. ., Bharadwaj, S. ., & Padvi, D. (2023). Evaluation of Physico-Phytochemical Parameters of Holarrhena Pubescens Wall.Ex G. Don. (Kutaja) Seed and Bark and Their Effect in Obesity Associated Hyperlipidemia: Pharmaceutical Science-Pharmacology. International Journal of Life Science and Pharma Research, 13(5), P14-P24. https://doi.org/10.22376/ijlpr.2023.13.5.P14-P24

Issue

Volume 13 Issue 5, September 2023

Section

Research Articles

Copyright (c) 2023 Rajkumar Gupta, Ombeer Pal, Shraddha Nayak, Mohan Yende, Ritu Wadhwa, Arundhati Banerje, Kanchanlata Tungare, Mustansir Bhori, Shishira Bharadwaj, Dnyaneshwar Padvi

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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.