A Review on Growth Factor Loaded Scaffolds for Rapid Healing of Bone Tissue
Life Sciences -Biotechnology
DOI:
https://doi.org/10.22376/ijlpr.2023.13.5.L176-L198Keywords:
Growth factors, Biomaterials, Bone regeneration, Angiogenesis, FibroblastsAbstract
Artificial bone implants from various sources, including metals, polymers, and bio-ceramics, turned out to be extensivelyoccupied in present-day tissue engineering applications. The biomaterials provide an essential platform for the osteoblast cells tomultiply, increase, and differentiate into mature osteocytes leading to bone regeneration in the defect site. Apart from biomaterialsand cells, the other essential component in tissue engineering is growth factors. Growth factors are the biomolecules responsiblefor transformation, growth, migration, and cell crawling on the biomaterial's surface. Many growth factors like BMP (BoneMorphogenetic Protein) family, (Transforming Growth Factor Beta) TGF-β, and VEGF (Vascular Endothelial Growth Factor)exhibit a crucial role in angiogenesis, extracellular matrix (ECM) formation and transformation of fibroblasts and other stem cellsinto osteocytes aiding in bone growth. In addition, the growth factors have higher renal clearance making it tough to maintain theirlevels at the site of injury, which demands a sustained release approach. Our review aims to explore various growth factors usedin treating bone defects; the primary objective is to understand each growth factor's role in the healing process and tailor thescaffold according to the requirement. Further, in this review, we have focused on the growth factors being used, their importance,and the sustained release strategies being followed for the efficient distribution of growth factors and, thus, bone healing bycovering the use of different growth factors in conjunction with biomaterials involved in the treatment of bone tissue defects.
References
Biga LM, Dawson S, Harwell A, Hopkins R, Kaufmann J, LeMaster M, et al. 6.3 Bone Structure. In: Anatomy & Physiology. OpenStax/Oregon State University; 2019.
Lee DK, Ki MR, Kim EH, Park CJ, Ryu JJ, Jang HS, et al. Biosilicated collagen/β-tricalcium phosphate composites as a BMP-2-delivering bone‐graft substitute for accelerated craniofacial bone regeneration. Biomaterials Research. 2021 Apr 21;25(1):1–11.
Multi-layered polydopamine coatings for the immobilization of growth factors onto highly-interconnected and bimodal PCL/HA-based scaffolds. Materials Science and Engineering: C. 2020 Dec 1;117:111245.
Yifei X, Yanan Y, Li J, Yue M, Hao W, Wang L, et al. Porous composite calcium citrate/polylactic acid materials with high mineralization activity and biodegradability for bone repair tissue engineering. Int J Polym Mater [Internet]. 2021 May 3 [cited 2022 Oct 13]; Available from: https://www.scinapse.io/papers/3010668654
NIR fluorescence for monitoring in vivo scaffold degradation along with stem cell tracking in bone tissue engineering. Biomaterials. 2020 Nov 1;258:120267.
Glucose cross-linked hydrogels conjugate HA nanorods as bone scaffolds: Green synthesis, characterization and in vitro studies. Mater Chem Phys. 2020 Feb 15;242:122515.
Reyes R, la Riva B D, Delgado A, Hernández A, Sánchez E, Évora C. Effect of triple growth factor controlled delivery by a brushite-PLGA system on a bone defect. Injury [Internet]. 2012 Mar [cited 2022 Oct 12];43(3). Available from: https://pubmed.ncbi.nlm.nih.gov/22035848/
Nath SD, Abueva C, Kim B, Lee BT. Chitosan-hyaluronic acid polyelectrolyte complex scaffold crosslinked with genipin for immobilization and controlled release of BMP-2. Carbohydr Polym [Internet]. 2015 Jan 22 [cited 2022 Oct 12];115. Available from: https://pubmed.ncbi.nlm.nih.gov/25439881/
Narasimhulu CA, Singla DK. The Role of Bone Morphogenetic Protein 7 (BMP-7) in Inflammation in Heart Diseases. Cells [Internet]. 2020 Feb [cited 2022 Oct 13];9(2). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073173/
Tong S, Xu DP, Liu ZM, Du Y, Wang XK. Synthesis of the New-Type Vascular Endothelial Growth Factor-Silk Fibroin-Chitosan Three-Dimensional Scaffolds for Bone Tissue Engineering and In Vitro Evaluation. J Craniofac Surg [Internet]. 2016 Mar [cited 2022 Oct 12];27(2). Available from: https://pubmed.ncbi.nlm.nih.gov/26890455/
Zhang Y, Cheng N, Miron R, Shi B, Cheng X. Delivery of PDGF-B and BMP-7 by mesoporous bioglass/silk fibrin scaffolds for the repair of osteoporotic defects. Biomaterials [Internet]. 2012 Oct [cited 2022 Oct 12];33(28). Available from: https://pubmed.ncbi.nlm.nih.gov/22763224/
De Witte TM, Fratila-Apachitei LE, Zadpoor AA, Peppas NA. Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices. Regen Biomater. 2018 Jun 9;5(4):197–211.
Sahoo S, Sinha A, Das M. Synthesis, characterization and in vitro biocompatibility study of strontium titanate ceramic: A potential biomaterial. J Mech Behav Biomed Mater. 2020 Feb;102:103494.
Rabiee SM, Nazparvar N, Azizian M, Vashaee D, Tayebi L. Effect of ion substitution on properties of bioactive glasses: A review [Internet]. Vol. 41, Ceramics International. 2015. p. 7241–51. Available from: http://dx.doi.org/10.1016/j.ceramint.2015.02.140
Cacciotti I. Bivalent cationic ions doped bioactive glasses: the influence of magnesium, zinc, strontium and copper on the physical and biological properties [Internet]. Vol. 52, Journal of Materials Science. 2017. p. 8812–31. Available from: http://dx.doi.org/10.1007/s10853-017-1010-0
Haugen HJ, Lyngstadaas SP, Rossi F, Perale G. Bone grafts: which is the ideal biomaterial? J Clin Periodontol. 2019 Jun;46 Suppl 21:92–102.
Mir M, Ali MN, Barakullah A, Gulzar A, Arshad M, Fatima S, et al. Synthetic polymeric biomaterials for wound healing: a review. Progress in Biomaterials. 2018 Feb 14;7(1):1–21.
Website [Internet]. Available from: https://royalsocietypublishing.org/doi/10.1098/rsif.2009.0379
Chitosan based nanofibers in bone tissue engineering. Int J Biol Macromol. 2017 Nov 1;104:1372–82.
Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategies. Adv Drug Deliv Rev. 2015 Apr 1;84:1–29.
Bone morphogenic protein-2 (BMP-2) loaded nanoparticles mixed with human mesenchymal stem cell in fibrin hydrogel for bone tissue engineering. J Biosci Bioeng. 2009 Dec 1;108(6):530–7.
Chitosan-based biomaterials for tissue engineering. Eur Polym J. 2013 Apr 1;49(4):780–92.
Scaffolds for Bone Tissue Engineering: State of the art and new perspectives. Materials Science and Engineering: C. 2017 Sep 1;78:1246–62.
Dang TT, Nikkhah M, Memic A, Khademhosseini A. Polymeric Biomaterials for Implantable Prostheses [Internet]. Natural and Synthetic Biomedical Polymers. 2014. p. 309–31. Available from: http://dx.doi.org/10.1016/b978-0-12-396983-5.00020-x
Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review. Acta Biomater. 2012 Apr 1;8(4):1401–21.
Chang PC, Liu BY, Liu CM, Chou HH, Ho MH, Liu HC, et al. Bone tissue engineering with novel rhBMP2-PLLA composite scaffolds. J Biomed Mater Res A. 2007 Jun 15;81(4):771–80.
Manring MM, Hawk A, Calhoun JH, Andersen RC. Treatment of War Wounds: A Historical Review [Internet]. Vol. 467, Clinical Orthopaedics & Related Research. 2009. p. 2168–91. Available from: http://dx.doi.org/10.1007/s11999-009-0738-5
Hench LL. The story of Bioglass® [Internet]. Vol. 17, Journal of Materials Science: Materials in Medicine. 2006. p. 967–78. Available from: http://dx.doi.org/10.1007/s10856-006-0432-z
Website [Internet]. Available from: https://doi.org/10.1111/j.1151-2916.1998.tb02540.x
Website [Internet]. Available from: https://doi.org/10.1111/j.1151-2916.1998.tb02540.x
Lee K, Silva EA, Mooney DJ. Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. J R Soc Interface [Internet]. 2011 Feb 6 [cited 2023 Mar 16];8(55). Available from: https://pubmed.ncbi.nlm.nih.gov/20719768/
Ferrand A, Eap S, Richert L, Lemoine S, Kalaskar D, Demoustier-Champagne S, et al. Osteogenetic properties of electrospun nanofibrous PCL scaffolds equipped with chitosan-based nanoreservoirs of growth factors. Macromol Biosci. 2014 Jan;14(1):45–55.
Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation. Acta Biomater. 2012 May 1;8(5):1768–77.
Peptides for bone tissue engineering. J Control Release. 2016 Dec 28;244:122–35.
Varkey M, Gittens SA, Uludag H. Growth factor delivery for bone tissue repair: an update. Expert Opin Drug Deliv [Internet]. 2004 Nov [cited 2023 Mar 16];1(1). Available from: https://pubmed.ncbi.nlm.nih.gov/16296718/
Biomimetic hydrogels for controlled biomolecule delivery to augment bone regeneration. Adv Drug Deliv Rev. 2012 Sep 1;64(12):1078–89.
Extracellular signaling molecules to promote fracture healing and bone regeneration. Adv Drug Deliv Rev. 2015 Nov 1;94:3–12.
Local and targeted drug delivery for bone regeneration. Curr Opin Biotechnol. 2016 Aug 1;40:125–32.
Nyberg E, Holmes C, Witham T, Grayson WL. Growth factor-eluting technologies for bone tissue engineering. Drug Deliv Transl Res. 2015 May 13;6(2):184–94.
Honda H, Tamai N, Naka N, Yoshikawa H, Myoui A. Bone tissue engineering with bone marrow-derived stromal cells integrated with concentrated growth factor in Rattus norvegicus calvaria defect model. J Artif Organs. 2013 Sep;16(3):305–15.
Dyondi D, Webster TJ, Banerjee R. A nanoparticulate injectable hydrogel as a tissue engineering scaffold for multiple growth factor delivery for bone regeneration. Int J Nanomedicine. 2013;8:47–59.
de Guzman RC, Saul JM, Ellenburg, Merrill MR, Coan HB, Smith TL, et al. Bone regeneration with BMP-2 delivered from keratose scaffolds. Biomaterials [Internet]. 2013 Feb [cited 2022 Oct 13];34(6). Available from: https://pubmed.ncbi.nlm.nih.gov/23211447/
Nandi SK, Kundu B, Basu D. Protein growth factors loaded highly porous chitosan scaffold: a comparison of bone healing properties. Mater Sci Eng C [Internet]. 2013 Apr 1 [cited 2022 Oct 13];33(3). Available from: https://pubmed.ncbi.nlm.nih.gov/23827571/
Shi Q, Li Y, Sun J, Zhang H, Chen L, Chen B, et al. The osteogenesis of bacterial cellulose scaffold loaded with bone morphogenetic protein-2. Biomaterials [Internet]. 2012 Oct [cited 2022 Oct 13];33(28). Available from: https://pubmed.ncbi.nlm.nih.gov/22727467/
Yu F, Geng D, Kuang Z, Huang S, Cheng Y, Chen Y, et al. Sequentially releasing self-healing hydrogel fabricated with TGFβ3-microspheres and bFGF to facilitate rat alveolar bone defect repair. Asian J Pharm Sci [Internet]. 2022 May [cited 2022 Oct 13];17(3). Available from: https://pubmed.ncbi.nlm.nih.gov/35782329/
Controlled delivery of icariin on small intestine submucosa for bone tissue engineering. Materials Science and Engineering: C. 2017 Feb 1;71:260–7.
Kim JH, Kim TH, Kang MS, Kim HW. Angiogenic Effects of Collagen/Mesoporous Nanoparticle Composite Scaffold Delivering VEGF165. Biomed Res Int [Internet]. 2016 Sep 5 [cited 2022 Oct 13];2016. Available from: https://doi.org/10.1155/2016/9676934
Fujioka-Kobayashi M, Schaller B, Kobayashi E, Hernandez M, Zhang Y, Miron RJ. Hyaluronic Acid Gel-Based Scaffolds as Potential Carrier for Growth Factors: An In Vitro Bioassay on Its Osteogenic Potential. J Clin Med Res [Internet]. 2016 Dec [cited 2022 Oct 13];5(12). Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5184785/
Talaei-KhozaniTahereh. Fabrication of platelet-rich plasma/silica scaffolds for bone tissue engineering. Bioinspired, Biomimetic and Nanobiomaterials [Internet]. 2018 Jun 20 [cited 2022 Oct 13]; Available from: https://www.icevirtuallibrary.com/doi/10.1680/jbibn.17.00007
Kim BS, Kim JS, Yang SS, Kim HW, Lim HJ, Lee J. Angiogenin-loaded fibrin/bone powder composite scaffold for vascularized bone regeneration. Biomaterials research [Internet]. 2015 Aug 25 [cited 2022 Oct 22];19. Available from: https://pubmed.ncbi.nlm.nih.gov/26331087/
Li Q, Zhou G, Yu X, Wang T, Xi Y, Tang Z. Porous deproteinized bovine bone scaffold with three-dimensional localized drug delivery system using chitosan microspheres. Biomed Eng Online [Internet]. 2015 Apr 15 [cited 2022 Oct 22];14. Available from: https://pubmed.ncbi.nlm.nih.gov/25881175/
Enzymatic crosslinked gelatin 3D scaffolds for bone tissue engineering. Int J Pharm. 2019 May 1;562:151–61.
Azizian S, Hadjizadeh A, Niknejad H. Chitosan-gelatin porous scaffold incorporated with Chitosan nanoparticles for growth factor delivery in tissue engineering. Carbohydr Polym. 2018 Jul 9;202:315–22.
Gümüşderelioğlu M, Aday S. Heparin-functionalized chitosan scaffolds for bone tissue engineering. Carbohydr Res [Internet]. 2011 Apr 1 [cited 2022 Oct 22];346(5). Available from: https://pubmed.ncbi.nlm.nih.gov/21333274/
Aligned electrospun cellulose scaffolds coated with rhBMP-2 for both in vitro and in vivo bone tissue engineering. Carbohydr Polym. 2019 Jun 1;213:27–38.
Park J, Lee SJ, Lee H, Park SA, Lee JY. Three dimensional cell printing with sulfated alginate for improved bone morphogenetic protein-2 delivery and osteogenesis in bone tissue engineering. Carbohydr Polym [Internet]. 2018 Sep 15 [cited 2022 Oct 22];196. Available from: https://pubmed.ncbi.nlm.nih.gov/29891290/
Sharmila G, Muthukumaran C, Kirthika S, Keerthana S, Kumar NM, Jeyanthi J. Fabrication and characterization of Spinacia oleracea extract incorporated alginate/carboxymethyl cellulose microporous scaffold for bone tissue engineering. Int J Biol Macromol [Internet]. 2020 Aug 1 [cited 2022 Oct 22];156. Available from: https://pubmed.ncbi.nlm.nih.gov/32294496/
Gambari L, Amore E, Raggio R, Bonani W, Barone M, Lisignoli G, et al. Hydrogen sulfide-releasing silk fibroin scaffold for bone tissue engineering. Mater Sci Eng C [Internet]. 2019 Sep [cited 2022 Oct 22];102. Available from: https://pubmed.ncbi.nlm.nih.gov/31147018/
Murphy CM, Schindeler A, Gleeson JP, Yu NY, Cantrill LC, Mikulec K, et al. A collagen-hydroxyapatite scaffold allows for binding and co-delivery of recombinant bone morphogenetic proteins and bisphosphonates. Acta Biomater [Internet]. 2014 May [cited 2022 Oct 22];10(5). Available from: https://pubmed.ncbi.nlm.nih.gov/24456759/
Jabbarzadeh E, Deng M, Lv Q, Jiang T, Khan YM, Nair LS, et al. VEGF-incorporated biomimetic poly(lactide-co-glycolide) sintered microsphere scaffolds for bone tissue engineering. J Biomed Mater Res B Appl Biomater [Internet]. 2012 Nov [cited 2022 Oct 13];100(8). Available from: https://pubmed.ncbi.nlm.nih.gov/22915492/
Eğri S, Eczacıoğlu N. Sequential VEGF and BMP-2 releasing PLA-PEG-PLA scaffolds for bone tissue engineering: I. Design and in vitro tests. Artif Cells Nanomed Biotechnol [Internet]. 2017 Mar [cited 2022 Oct 13];45(2). Available from: https://pubmed.ncbi.nlm.nih.gov/26912262/
Jain S, Meka K Sr, Chatterjee K. Curcumin eluting nanofibers augment osteogenesis toward phytochemical based bone tissue engineering. Biomed Mater [Internet]. 2016 Oct 6 [cited 2022 Oct 13];11(5). Available from: https://pubmed.ncbi.nlm.nih.gov/27710925/
Bouyer M, Guillot R, Lavaud J, Plettinx C, Olivier C, Curry V, et al. Surface delivery of tunable doses of BMP-2 from an adaptable polymeric scaffold induces volumetric bone regeneration. Biomaterials [Internet]. 2016 Oct [cited 2022 Oct 13];104. Available from: https://pubmed.ncbi.nlm.nih.gov/27454063/
Lee SJ, Lee D, Yoon TR, Kim HK, Jo HH, Park JS, et al. Surface modification of 3D-printed porous scaffolds via mussel-inspired polydopamine and effective immobilization of rhBMP-2 to promote osteogenic differentiation for bone tissue engineering. Acta Biomater [Internet]. 2016 Aug [cited 2022 Oct 13];40. Available from: https://pubmed.ncbi.nlm.nih.gov/26868173/
Rampichová M, Buzgo M, Míčková A, Vocetková K, Sovková V, Lukášová V, et al. Platelet-functionalized three-dimensional poly-ε-caprolactone fibrous scaffold prepared using centrifugal spinning for delivery of growth factors. Int J Nanomedicine. 2017;12:347.
Rahman M, Peng XL, Zhao XH, Gong HL, Sun XD, Wu Q, et al. 3D bioactive cell-free-scaffolds for in-vitro/in-vivo capture and directed osteoinduction of stem cells for bone tissue regeneration. Bioactive materials [Internet]. 2021 Apr 21 [cited 2022 Oct 22];6(11). Available from: https://pubmed.ncbi.nlm.nih.gov/33997495/
Li X, Yi W, Jin A, Duan Y, Min S. Effects of sequentially released BMP-2 and BMP-7 from PELA microcapsule-based scaffolds on the bone regeneration. Am J Transl Res. 2015;7(8):1417.
Kim TH, Yun YP, Park YE, Lee SH, Yong W, Kundu J, et al. In vitro and in vivo evaluation of bone formation using solid freeform fabrication-based bone morphogenic protein-2 releasing PCL/PLGA scaffolds. Biomed Mater [Internet]. 2014 Apr [cited 2022 Oct 22];9(2). Available from: https://pubmed.ncbi.nlm.nih.gov/24518200/
Murphy WL, Peters MC, Kohn DH, Mooney DJ. Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering. Biomaterials [Internet]. 2000 Dec [cited 2022 Oct 22];21(24). Available from: https://pubmed.ncbi.nlm.nih.gov/11071602/
Basmanav FB, Kose GT, Hasirci V. Sequential growth factor delivery from complexed microspheres for bone tissue engineering. Biomaterials [Internet]. 2008 Nov [cited 2022 Oct 22];29(31). Available from: https://pubmed.ncbi.nlm.nih.gov/18691753/
Kanczler JM, Ginty PJ, Barry JJ, Clarke NM, Howdle SM, Shakesheff KM, et al. The effect of mesenchymal populations and vascular endothelial growth factor delivered from biodegradable polymer scaffolds on bone formation. Biomaterials [Internet]. 2008 Apr [cited 2022 Oct 22];29(12). Available from: https://pubmed.ncbi.nlm.nih.gov/18234329/
Zhang Q, Qin M, Zhou X, Nie W, Wang W, Li L, et al. Porous nanofibrous scaffold incorporated with S1P loaded mesoporous silica nanoparticles and BMP-2 encapsulated PLGA microspheres for enhancing angiogenesis and osteogenesis. J Mater Chem B Mater Biol Med. 2018 Oct 31;6(42):6731–43.
Sahoo S, Ang LT, Goh JC, Toh SL. Growth factor delivery through electrospun nanofibers in scaffolds for tissue engineering applications. J Biomed Mater Res A [Internet]. 2010 Jun 15 [cited 2022 Oct 22];93(4). Available from: https://pubmed.ncbi.nlm.nih.gov/20014288/
Chen L, Shao L, Wang F, Huang Y, Gao F. Enhancement in sustained release of antimicrobial peptide and BMP-2 from degradable three dimensional-printed PLGA scaffold for bone regeneration. RSC Adv. 2019 Apr 3;9(19):10494–507.
RhBMP-2-loaded calcium silicate/calcium phosphate cement scaffold with hierarchically porous structure for enhanced bone tissue regeneration. Biomaterials. 2013 Dec 1;34(37):9381–92.
Overman JR, Helder MN, ten Bruggenkate CM, Schulten EA, Klein-Nulend J, Bakker AD. Growth factor gene expression profiles of bone morphogenetic protein-2-treated human adipose stem cells seeded on calcium phosphate scaffolds in vitro. Biochimie [Internet]. 2013 Dec [cited 2022 Oct 13];95(12). Available from: https://pubmed.ncbi.nlm.nih.gov/24028822/
Gu Z, Zhang X, Li L, Wang Q, Yu X, Feng T. Acceleration of segmental bone regeneration in a rabbit model by strontium-doped calcium polyphosphate scaffold through stimulating VEGF and bFGF secretion from osteoblasts. Mater Sci Eng C [Internet]. 2013 Jan 1 [cited 2022 Oct 13];33(1). Available from: https://pubmed.ncbi.nlm.nih.gov/25428072/
Chen S, Shi Y, Zhang X, Ma J. Evaluation of BMP-2 and VEGF loaded 3D printed hydroxyapatite composite scaffolds with enhanced osteogenic capacity in vitro and in vivo. Mater Sci Eng C [Internet]. 2020 Jul [cited 2022 Oct 13];112. Available from: https://pubmed.ncbi.nlm.nih.gov/32409051/
Mijiritsky E, Ferroni L, Gardin C, Bressan E, Zanette G, Piattelli A, et al. Porcine Bone Scaffolds Adsorb Growth Factors Secreted by MSCs and Improve Bone Tissue Repair. Materials [Internet]. 2017 Sep 8 [cited 2022 Oct 13];10(9). Available from: https://pubmed.ncbi.nlm.nih.gov/28885576/
Suárez-González D, Lee JS, Diggs A, Lu Y, Nemke B, Markel M, et al. Controlled multiple growth factor delivery from bone tissue engineering scaffolds via designed affinity. Tissue Eng Part A [Internet]. 2014 Aug [cited 2022 Oct 22];20(15-16). Available from: https://pubmed.ncbi.nlm.nih.gov/24350567/
Perez RA, El-Fiqi A, Park JH, Kim TH, Kim JH, Kim HW. Therapeutic bioactive microcarriers: co-delivery of growth factors and stem cells for bone tissue engineering. Acta Biomater [Internet]. 2014 Jan [cited 2022 Oct 22];10(1). Available from: https://pubmed.ncbi.nlm.nih.gov/24121192/
Florczyk SJ, Leung M, Jana S, Li Z, Bhattarai N, Huang JI, et al. Enhanced bone tissue formation by alginate gel-assisted cell seeding in porous ceramic scaffolds and sustained release of growth factor. J Biomed Mater Res A [Internet]. 2012 Dec [cited 2022 Oct 13];100(12). Available from: https://pubmed.ncbi.nlm.nih.gov/22767533/
Jun SH, Lee EJ, Jang TS, Kim HE, Jang JH, Koh YH. Bone morphogenic protein-2 (BMP-2) loaded hybrid coating on porous hydroxyapatite scaffolds for bone tissue engineering. J Mater Sci Mater Med [Internet]. 2013 Mar [cited 2022 Oct 13];24(3). Available from: https://pubmed.ncbi.nlm.nih.gov/23344924/
Su Y, Su Q, Liu W, Lim M, Venugopal JR, Mo X, et al. Controlled release of bone morphogenetic protein 2 and dexamethasone loaded in core-shell PLLACL-collagen fibers for use in bone tissue engineering. Acta Biomater [Internet]. 2012 Feb [cited 2022 Oct 13];8(2). Available from: https://pubmed.ncbi.nlm.nih.gov/22100346/
Fujioka-Kobayashi M, Ota MS, Shimoda A, Nakahama K, Akiyoshi K, Miyamoto Y, et al. Cholesteryl group- and acryloyl group-bearing pullulan nanogel to deliver BMP2 and FGF18 for bone tissue engineering. Biomaterials [Internet]. 2012 Oct [cited 2022 Oct 13];33(30). Available from: https://pubmed.ncbi.nlm.nih.gov/22800537/
Comparative study of osteogenic potential of a composite scaffold incorporating either endogenous bone morphogenetic protein-2 or exogenous phytomolecule icaritin: An in vitro efficacy study. Acta Biomater. 2012 Aug 1;8(8):3128–37.
Farokhi M, Mottaghitalab F, Ai J, Shokrgozar MA. Sustained release of platelet-derived growth factor and vascular endothelial growth factor from silk/calcium phosphate/PLGA based nanocomposite scaffold. Int J Pharm [Internet]. 2013 Sep 15 [cited 2022 Oct 13];454(1). Available from: https://pubmed.ncbi.nlm.nih.gov/23856159/
Santo VE, Duarte AR, Popa EG, Gomes ME, Mano JF, Reis RL. Enhancement of osteogenic differentiation of human adipose derived stem cells by the controlled release of platelet lysates from hybrid scaffolds produced by supercritical fluid foaming. J Control Release [Internet]. 2012 Aug 20 [cited 2022 Oct 13];162(1). Available from: https://pubmed.ncbi.nlm.nih.gov/22698936/
Lu H, Kawazoe N, Kitajima T, Myoken Y, Tomita M, Umezawa A, et al. Spatial immobilization of bone morphogenetic protein-4 in a collagen-PLGA hybrid scaffold for enhanced osteoinductivity. Biomaterials [Internet]. 2012 Sep [cited 2022 Oct 13];33(26). Available from: https://pubmed.ncbi.nlm.nih.gov/22698726/
Choi DH, Park CH, Kim IH, Chun HJ, Park K, Han DK. Fabrication of core-shell microcapsules using PLGA and alginate for dual growth factor delivery system. J Control Release [Internet]. 2010 Oct 15 [cited 2022 Oct 13];147(2). Available from: https://pubmed.ncbi.nlm.nih.gov/20647022/
Biomimetic gelatin/chitosan/polyvinyl alcohol/nano-hydroxyapatite scaffolds for bone tissue engineering. Mater Des. 2021 Sep 1;207:109865.
Development of PLGA-coated β-TCP scaffolds containing VEGF for bone tissue engineering. Materials Science and Engineering: C. 2016 Dec 1;69:780–8.
Bastami F, Paknejad Z, Jafari M, Salehi M, Rezai RM, Khojasteh A. Fabrication of a three-dimensional β-tricalcium-phosphate/gelatin containing chitosan-based nanoparticles for sustained release of bone morphogenetic protein-2: Implication for bone tissue engineering. Mater Sci Eng C [Internet]. 2017 Mar 1 [cited 2022 Oct 13];72. Available from: https://pubmed.ncbi.nlm.nih.gov/28024612/
Sobhani A, Rafienia M, Ahmadian M, Naimi-Jamal M. Fabrication and Characterization of Polyphosphazene/Calcium Phosphate Scaffolds Containing Chitosan Microspheres for Sustained Release of Bone Morphogenetic Protein 2 in Bone Tissue Engineering. 2017 [cited 2022 Oct 13]; Available from: https://doi.org/10.1007/s13770-017-0056-z
Lei Y, Xu Z, Ke Q, Yin W, Chen Y, Zhang C, et al. Strontium hydroxyapatite/chitosan nanohybrid scaffolds with enhanced osteoinductivity for bone tissue engineering. Mater Sci Eng C [Internet]. 2017 Mar 1 [cited 2022 Oct 13];72. Available from: https://pubmed.ncbi.nlm.nih.gov/28024569/
Lin H, Tang Y, Lozito TP, Oyster N, Kang RB, Fritch MR, et al. Projection Stereolithographic Fabrication of BMP-2 Gene-activated Matrix for Bone Tissue Engineering. Sci Rep. 2017 Sep 12;7(1):1–11.
Gentile P, Nandagiri VK, Daly J, Chiono V, Mattu C, Tonda-Turo C, et al. Localised controlled release of simvastatin from porous chitosan-gelatin scaffolds engrafted with simvastatin loaded PLGA-microparticles for bone tissue engineering application. Mater Sci Eng C [Internet]. 2016 Feb [cited 2022 Oct 13];59. Available from: https://pubmed.ncbi.nlm.nih.gov/26652371/
Chiu YC, Fong EL, Grindel BJ, Kasper FK, Harrington DA, Farach-Carson MC. Sustained delivery of recombinant human bone morphogenetic protein-2 from perlecan domain I - functionalized electrospun poly (ε-caprolactone) scaffolds for bone regeneration. Journal of experimental orthopaedics [Internet]. 2016 Dec [cited 2022 Oct 13];3(1). Available from: https://pubmed.ncbi.nlm.nih.gov/27714703/
Patntirapong S, Janvikul W, Theerathanagorn T, Singhatanadgit W. Osteoinduction of stem cells by collagen peptide-immobilized hydrolyzed poly(butylene succinate)/β-tricalcium phosphate scaffold for bone tissue engineering. J Biomater Appl [Internet]. 2017 Jan [cited 2022 Oct 13];31(6). Available from: https://pubmed.ncbi.nlm.nih.gov/30208806/
Zhao X, Han Y, Li J, Cai B, Gao H, Feng W, et al. BMP-2 immobilized PLGA/hydroxyapatite fibrous scaffold via polydopamine stimulates osteoblast growth. Mater Sci Eng C [Internet]. 2017 Sep 1 [cited 2022 Oct 13];78. Available from: https://pubmed.ncbi.nlm.nih.gov/28576035/
Cao L, Yu Y, Wang J, Werkmeister JA, McLean KM, Liu C. 2-N, 6-O-sulfated chitosan-assisted BMP-2 immobilization of PCL scaffolds for enhanced osteoinduction. Mater Sci Eng C [Internet]. 2017 May 1 [cited 2022 Oct 13];74. Available from: https://pubmed.ncbi.nlm.nih.gov/28254298/
Zhang HX, Zhang XP, Xiao GY, Hou Y, Cheng L, Si M, et al. In vitro and in vivo evaluation of calcium phosphate composite scaffolds containing BMP-VEGF loaded PLGA microspheres for the treatment of avascular necrosis of the femoral head. Mater Sci Eng C [Internet]. 2016 Mar [cited 2022 Oct 13];60. Available from: https://pubmed.ncbi.nlm.nih.gov/26706534/
Bae MS, Ko NR, Lee SJ, Lee JB, Heo DN, Byun W, et al. Development of novel photopolymerizable hyaluronic acid/heparin-based hydrogel scaffolds with a controlled release of growth factors for enhanced bone regeneration. Macromol Res. 2016 Aug 11;24(9):829–37.
Quinlan E, López-Noriega A, Thompson E, Kelly HM, Cryan SA, O’Brien FJ. Development of collagen-hydroxyapatite scaffolds incorporating PLGA and alginate microparticles for the controlled delivery of rhBMP-2 for bone tissue engineering. J Control Release [Internet]. 2015 Jan 28 [cited 2022 Oct 22];198. Available from: https://pubmed.ncbi.nlm.nih.gov/25481441/
Zheng L, Wang L, Qin J, Sun X, Yang T, Ni Y, et al. New Biodegradable Implant Material Containing Hydrogel with Growth Factors of Lyophilized PRF in Combination with an nHA/PLGA Scaffold. J Hard Tissue Biol. 2015;24(1):54–60.
Wang Z, Wang K, Lu X, Li M, Liu H, Xie C, et al. BMP-2 encapsulated polysaccharide nanoparticle modified biphasic calcium phosphate scaffolds for bone tissue regeneration. J Biomed Mater Res A [Internet]. 2015 Apr [cited 2022 Oct 22];103(4). Available from: https://pubmed.ncbi.nlm.nih.gov/25100662/
He X, Liu Y, Yuan X, Lu L. Enhanced healing of rat calvarial defects with MSCs loaded on BMP-2 releasing chitosan/alginate/hydroxyapatite scaffolds. PLoS One [Internet]. 2014 Aug 1 [cited 2022 Oct 22];9(8). Available from: https://pubmed.ncbi.nlm.nih.gov/25084008/
Fan J, Park H, Lee MK, Bezouglaia O, Fartash A, Kim J, et al. Adipose-derived stem cells and BMP-2 delivery in chitosan-based 3D constructs to enhance bone regeneration in a rat mandibular defect model. Tissue Eng Part A [Internet]. 2014 Aug [cited 2022 Oct 22];20(15-16). Available from: https://pubmed.ncbi.nlm.nih.gov/24524819/
Sheehy EJ, Miller GJ, Amado I, Raftery RM, Chen G, Cortright K, et al. Mechanobiology-informed regenerative medicine: Dose-controlled release of placental growth factor from a functionalized collagen-based scaffold promotes angiogenesis and accelerates bone defect healing. J Control Release [Internet]. 2021 Jun 10 [cited 2022 Oct 22];334. Available from: https://pubmed.ncbi.nlm.nih.gov/33811984/
Wang G, Qiu J, Zheng L, Ren N, Li J, Liu H, et al. Sustained delivery of BMP-2 enhanced osteoblastic differentiation of BMSCs based on surface hydroxyapatite nanostructure in chitosan-HAp scaffold. J Biomater Sci Polym Ed [Internet]. 2014 [cited 2022 Oct 22];25(16). Available from: https://pubmed.ncbi.nlm.nih.gov/25166866/
In Situ Controlled Release of rhBMP-2 in Gelatin-Coated 3D Porous Poly(ε-caprolactone) Scaffolds for Homogeneous Bone Tissue Formation - Google Search [Internet]. [cited 2022 Oct 22]. Available from: https://www.google.com/search?q=In+Situ+Controlled+Release+of+rhBMP-2+in+Gelatin-Coated+3D+Porous+Poly(%CE%B5-caprolactone)+Scaffolds+for+Homogeneous+Bone+Tissue+Formation&rlz=1C1CHBF_enIN1020IN1020&oq=In+Situ+Controlled+Release+of+rhBMP-2+in+Gelatin-Coated+3D+Porous+Poly(%CE%B5-caprolactone)+Scaffolds+for+Homogeneous+Bone+Tissue+Formation&aqs=chrome..69i57j69i64l2.1288j0j4&sourceid=chrome&ie=UTF-8
Osseointegration evaluation of UHMWPE and PEEK-based scaffolds with BMP-2 using model of critical-size cranial defect in mice and push-out test. J Mech Behav Biomed Mater. 2021 Jul 1;119:104477.
Controlled growth factor delivery system with osteogenic-angiogenic coupling effect for bone regeneration. Journal of Orthopaedic Translation. 2021 Nov 1;31:110–25.
Bal Z, Korkusuz F, Ishiguro H, Okada R, Kushioka J, Chijimatsu R, et al. A novel nano-hydroxyapatite/synthetic polymer/bone morphogenetic protein-2 composite for efficient bone regeneration. Spine J [Internet]. 2021 May [cited 2022 Oct 22];21(5). Available from: https://pubmed.ncbi.nlm.nih.gov/33493682/
Kong X, Wang J, Cao L, Yu Y, Liu C. Enhanced osteogenesis of bone morphology protein-2 in 2-N,6-O-sulfated chitosan immobilized PLGA scaffolds. Colloids Surf B Biointerfaces [Internet]. 2014 Oct 1 [cited 2022 Oct 22];122. Available from: https://pubmed.ncbi.nlm.nih.gov/25084565/
Mussel-inspired hybrid coating functionalized porous hydroxyapatite scaffolds for bone tissue regeneration. Colloids Surf B Biointerfaces. 2019 Jul 1;179:470–8.
Thomas A, Johnson E, Agrawal AK, Bera J. Preparation and characterization of glass–ceramic reinforced alginate scaffolds for bone tissue engineering. J Mater Res. 2019 Nov;34(22):3798–809.
Hu Y, Zheng L, Zhang J, Lin L, Shen Y, Zhang X, et al. Dual delivery of bone morphogenetic protein-2 and basic fibroblast growth factor from nanohydroxyapatite/collagen for bone tissue engineering. Applied Biological Chemistry. 2019 Sep 27;62(1):1–9.
3D printing of silk fibroin-based hybrid scaffold treated with platelet rich plasma for bone tissue engineering. Bioactive Materials. 2019 Dec 1;4:256–60.
Surface functionalization of dual growth factor on hydroxyapatite-coated nanofibers for bone tissue engineering. Appl Surf Sci. 2020 Aug 1;520:146311.
Yilgor P, Tuzlakoglu K, Reis RL, Hasirci N, Hasirci V. Incorporation of a sequential BMP-2/BMP-7 delivery system into chitosan-based scaffolds for bone tissue engineering. Biomaterials [Internet]. 2009 Jul [cited 2022 Oct 22];30(21). Available from: https://pubmed.ncbi.nlm.nih.gov/19361857/
BMP-2 incorporated biomimetic CaP coating functionalized 3D printed Ti6Al4V scaffold induces ectopic bone formation in a dog model. Mater Des. 2022 Mar 1;215:110443.
Assessment of bone morphogenic protein and hydroxyapatite–titanium dioxide composites for bone implant materials. Surf Coat Technol. 2015 Aug 25;276:168–74.
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Copyright (c) 2023 Yochana Boddepalli, Nikhitha Chava, Sarvani Gadiraju, Kavya Sri Pachchava, Karthik Kotikalapudi, Nadeem Siddiqui
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