C.N.S. Protective Drugs: An Overview
Life Sciences
DOI:
https://doi.org/10.22376/ijlpr.2023.13.3.SP1.L27-L34Keywords:
Medicinal Plants, Alzheimer's Disease, Anxiety, Stress and Anxiety, Stress, CNS Disorders, , Medhya RasayanaAbstract
Although regulatory authorities presently authorize extremely few drugs for dealing with multifactorial conditions and conditions of cognition such as Alzheimer's, specific plant-derived agents, consisting of, for instance, galantamine and rivastigmine (a semi-synthetic derivative of physostigmine) finding an application in contemporary medicine. However, in Ayurveda, the Indian traditional system of medicine which is more than 5000 years of ages, selected plants have long been categorized as 'Medhyarasayanas,' from the Sanskrit words 'Medhya,' indicating intellect or cognition, and 'Rasayana,' implying 'rejuvenation.' These plants are utilized both in natural and traditional medicine and offer advantages that pharmaceutical drugs do not have. The article is an attempt to examine the most critical medical plants, consisting of Vacha (Acorus calamus), Ashwagandha (Withania somnifera), Vidhara (Argyreia Nervosa), Shankhapushpi (Convolvulus prostratus), Shatavari (Asparagus racemosus), Mandukaparni (Centella Asiatica), Brahmi (Bacopa monnieri), Jyotishmati (Celastrus paniculatus) which are extensively used for their reputed effectiveness in C.N.S. conditions. This paper’s main aim is to explore C.N.S. Protective drugs or Medhya Rasayana mentioned in Ayurvedic classical textbooks concerning modern science mode of actions and to study the mechanism of the C.N.S. protective drugs. The source for this study is collected from classical Ayurvedic books and commentaries, modern medical science textbooks, and different articles from Pubmed, D.H.A.R.A., Google Scholar, etc. Various Medhya Rasayana mentioned in Ayurvedic texts have potent qualities to enhance memory and relieve medical illnesses related to C.N.S., whether it is related to mental or sensory problems. So, various safe and natural remedies are available in Ayurveda; long-term or short-term mental health can be recovered without any life-threatening complication.
References
Kennedy DO, Wightman EL. Herbal extracts and phytochemicals: secondary plant metabolites and the enhancement of human brain function. Adv Nutr. 2011 Jan 1;2(1):32-50. doi 10.3945/an.110.000117, PMID 22211188.
Dhanasekaran M, Tharakan B, Holcomb LA, Hitt AR, Young KA, Manyam BV. Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera. Phytother Res. 2007 Oct;21(10):965-9. doi 10.1002/ptr.2195, PMID 17604373.
Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): a review. Altern Med Rev. 2000 Aug 1;5(4):334-46. PMID 10956379.
Dhanasekaran M, Tharakan B, Holcomb LA, Hitt AR, Young KA, Manyam BV. Neuroprotective mechanisms of ayurvedic antidementia botanical Bacopa monniera. Phytother Res. 2007 Oct;21(10):965-9. doi 10.1002/ptr.2195, PMID 17604373.
Alzheimer’s Association. 2010 Alzheimer’s disease facts and figures. Alzheimers Dem. 2010;6(2):158-94. doi: 10.1016/j.jalz.2010.01.009.
Kumar R, Sharma S, Sharma S. A review on Vacha: an effective medicinal plant.
Bramhanand T, editor, Chapter 4. Verse-13 Chaukhamba Surabharati Prakashana. In: Sharagadhara Samhita of pandit Sharangadharacharya, Poorvakhanda; Chaturthodhyaya. 1st ed. Vol. 48; 2012.
Acharya YT, editor, Chapter 27. Verse-1 Varanasi: Choukhamba Sanskrita Sansthana. In: Sushrut Samhita with Dalhan's Nibandha Sangraha Teeka, Chikitsa Sthana; Sarvopaghatshamaniya. 1st ed. Vol. 498; 2009.
Acharya YT, editor, Chapter 46. Verse-150 Varanasi: Choukhamba Sanskrita Sansthana. In: Sushruta Samhita of Sushruta with Dalhan's Nibandha Sangraha Teeka, sutra Sthana; Annapanavidhi. 1st ed. Vol. 227; 2009.
Acharya YT, editor, Chapter 1/3 Verse-30 Varanasi: Choukhamba Prakashana. Agnivesha. In: Caraka Samhita with Chakrapani’s Ayurveda Deepika Teeka, Chikitsa Sthana; Rasayana Adhyaya Trutiya Pada. 1st ed. Vol. 385; 1994.
Zahiruddin S, Bassist P, Parveen A, Parveen R, Khan W, Ahmad S. Ashwagandha in brain disorders: an evaluation of current developments. J Ethnopharmacol. 2020 Jul 15;257:112876.
Zahiruddin S, Bassist P, Parveen A, Parveen R, Khan W, Ahmad S. Ashwagandha in brain disorders: a review of current developments. J Ethnopharmacol. 2020 Jul 15;257:112876.
Patnaik N. Role of medicinal plants (Brahmi and ashwagandha) in the treatment of Alzheimer’s illness.
Modi AJ, Khadabadi SS, Deokate UA, Farooqui IA, Deore SL, Gangwani MR et al. f: phytochemistry, pharmacognosy, and pharmacological studies. J Pharmacogn Phytother. 2010 Apr 30;2(3):34-42.
Malik J, Karan M, Vasisht K. Nootropic, anxiolytic and CNS-depressant studies on different plant sources of shankhpushpi. Pharm Biol. 2011 Dec 1;49(12):1234-42. doi: 10.3109/13880209.2011.584539, PMID 21846173.
Farooqui AA, Farooqui T, Madan A, Ong JH, Ong WY. Ayurvedic medicine for the treatment of dementia: mechanistic elements. Evid-Based Complement Nat Med. 2018 Oct;2018.
Lalert L, Kruevaisayawan H, Amatyakul P, Ingkaninan K, Khongsombat O. Neuroprotective impact of Asparagus racemosus root extract via the improvement of brain-derived neurotrophic factor and estrogen receptor in ovariectomized rats. J Ethnopharmacol. 2018 Oct 28;225:336-41. doi 10.1016/j.jep.2018.07.014, PMID 30009979.
Kant R, Srivastav PP, Datta AK. The medicinal function of Centella asiatica and its applications in the Dahi: A research study evaluation. J Pharm Res Int. 2019;28(6):1-9.
Patnaik N. Role of medicinal plants (Brahmi and ashwagandha) in the treatment of Alzheimer’s disease.
Dubey T, Brahmi CS (Bacopamonnieri). An ayurvedic herb versus Alzheimer’s disease. Arch Biochem Biophys. 2019 Nov 15;676:108153.
Sharma P, Shrivastava NM, Shrivastava S, Bhopal MP. Role of ”Jyotishmati” in the treatment of C.N.S. conditions. International Conference on ”Current Development in Science & Technology”(I.C.R.A.S.T. 2017); 2017. p. 29-30.
Sharma R, Kabra A, Rao MM, Prajapati PK. Natural and Holistic services for Neurodegenerative and Depressive conditions: leads from Ayurveda. Present Pharm Style. 2018 Jun 1;24(22):2597-608.
Mishra B, Nighatu B, Varga H Chunekar KC, editor. Varanasi: Chaukambha Bharati Academy [reprint]; 2010.
Madhav M. Mutalik Maitreyi, Tinospora cordifolia – role in depression, cognition, and memory. Aust J Med Herbalism.
Joshi H, Parle M. Nardostachys jatamansi improves learning and memory in mice. J Med Food. 2006;9(1):113-8. doi 10.1089/jmf.2006.9.113, PMID 16579738.
Chandre R, Upadhyay BN, Murthy KH. Clinical evaluation of Kushmanda Ghrita in the management of depressive e illness. Ayu. 2011;32(2):230-3. doi: 10.4103/0974-8520.92592, PMID 22408308.
Luo Y, Smith JV, Paramasivam V, Burdick A, Curry KJ, Buford JP, et al. Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761. Proc Natl Acad Sci U S A. 2002;99(19):12197-202. doi 10.1073/pnas.182425199, PMID 12213959.
Oliveira AI, Pinho C, Sarmento B, Dias AC. Neuroprotective activity of Hypericum perforatum and its major components. Front Plant Sci. 2016 Jul 11;7:1004. doi 10.3389/fpls.2016.01004, PMID 27462333.
Pedrosa EC, Bezerra AP, da Costa IM, Pinheiro FI, Guzen FP. Neuroprotective profile of Piper Methysticum (Kava) and its effects on the central nervous system: a systematic review. J Pharmacol Chem Biol Sci. 2020;2:55-84.
Buchbauer G, Jäger W, Jirovetz L, Meyer F, Dietrich H. Effects of valerian root oil, borneol, isoborneol, bornyl acetate, and isobornyl acetate on the motility of laboratory animals (mice) after inhalation. Pharmazie. 1992;47(8):620-2. PMID 1438515.
Sakamoto T, Mitani Y, Nakajima K. Psychotropic effects of Japanese valerian root extract. Chem Pharm Bull (Tokyo). 1992;40(3):758-61. doi 10.1248/cpb.40.758, PMID 1611689.
Agnivesha, Charaka, Dridhabala, Samhita C, Sthana C, Adhyaya R, et al., 1/1/7. 2, Ayushi Hindi commentary Khushvaha Vd, editor HS. 1st ed. Varanasi: Chaukhambha Orientalia Publisher, 2009;30.
Vagbhata AS, Sthana S, Adhyaya D, 20. 3, English commentary by Prof. Murthy KR. 9th ed. Varanasi: Chaukhambha Orientalia Publisher; 2005. p. 369.
Nalini K, Aroor AR, Karanth KS, Rao A. Effect of Centella asiatica fresh leaf aqueous extract on learning and memory, and biogenic amine turnover in albino rats. Fitoterapia. 1992;3:232-7.
Veerendra K, Gupta YK. Centella asiatica (L.) Urban: from traditional medicine to modern medicine with neuroprotective potential. Evid Based Complement Alternat Med;2012:8.
Chin YW, Jung HA, Liu Y, Su BN, Castoro JA, Keller WJ et al. Anti-oxidant constituents of the roots and stolons of licorice (Glycyrrhiza glabra). J Agric Food Chem. 2007;55(12):4691-7. doi: 10.1021/jf0703553, PMID 17516657.
Wijeweera P, Arnason JT, Koszycki D, Merali Z. Evaluation of anxiolytic properties of Gotukola–(Centella asiatica) extracts and asiaticoside in rat behavioral models. Phytomedicine. 2006;13(9-10):668-76. doi 10.1016/j.phymed.2006.01.011, PMID 16488124.
Reddy KY. Review on effect of natural memory enhancing drugs on dementia. Int J Phytopharmacol. 2010;1:1-7.
Muralidharan P. Cerebroprotective effect of Glycerrhyza glabra Linn root extract on a hypoxic rat. J Bangladesh Pharmacol Soc. 2009;4:60-4.
Agrawal A. Effect of Tinospora cordifolia on learning and memory in normal and memory deficit rats. Indian J Pharmacol. 2002;34:339-49.
Bairy KL. Efficacy of Tinospora cordifolia on learning and memory in healthy volunteers: A double-blind, randomized, placebo controlled study. Iran J Pharmacol Ther. 2004;3:57-60.
Gupta AK. Quality standards of Indian medicinal plants. Vol. 1. New Delhi: Indian Council of Medical Research; 2003. p. 217.
Agnivesha, Charaka, Dridhabala, Samhita C, Sthana C, Adhyaya R, et al. Ayushi Hindi commentary. 1st ed Khushvaha Vd, editor HS. Vol. 2009. Varanasi: Chaukhambha Orientalia Publisher; 1/3/31. p. 30.
Kokate CK. Textbook: pharmacognosy. 29th ed. Pune: Nirali Publication; 2004. p. 164.
Singh RH, Narsimhamurthy K, Singh G. Neuronutrient impact of Ayurvedic Rasayana therapy in brain aging. Biogerontology. 2008;9(6):369-74. doi: 10.1007/s10522-008-9185-z, PMID 18931935.
Borude M, Anand R, Ugale S. A critical review on medhya rasayana in AYURVEDA.
Published
How to Cite
Issue
Section
Copyright (c) 2023 Jagruti Tambakhe, Varinder Singh, Shweta Parwe, Milind Nisargandha, Sheetal Asutkar

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

