Human Papillomavirus (Hpv) Vaccination of The Girl Child: An Intervention for Primary Prevention of Cervical Cancer in India

Life Sciences-Pediatrics

Authors

  • Shanthi Ramesh Department of Pediatrics, Sree Balaji Medical College& Hospital, Chennai, India https://orcid.org/0000-0002-5321-9503
  • Somasekar R Department of Pediatrics, Sree Balaji Medical College& Hospital, Chennai, India
  • Sundari S Department of Pediatrics, Sree Balaji Medical College& Hospital, Chennai, India

DOI:

https://doi.org/10.22376/ijpbs/lpr.2022.12.6.L165-172

Keywords:

HPV vaccination, Nonavalent vaccine, human papillomavirus (HPV), cervix, cancer elimination, and Pap smear

Abstract

This review gives a comprehensive account of the currently available HPV vaccines including the Nonavalent vaccine which was not covered by some articles. The review includes the current burden of cervical cancer globally and in India. It also outlines the cervical cancer elimination initiative envisaged by the National Health Mission and the World Health Organization. This review aims to highlight the importance of cervical cancer prevention through HPV vaccination and regular screening program. The Human Papillomavirus infection is an established cause of cervical cancer in women. Cervical cancer is the second leading cause of cancer deaths among women in India. India has a young population with more than 436.7 million women aged 15 years and older at risk of developing cervical cancer. There is mounting evidence that cervical cancer is highly preventable. Primary prevention can be done effectively by vaccinating adolescent girls aged 9 to 14 years with the HPV vaccine. Three HPV vaccines, namely the Bivalent, Quadrivalent, and Nonavalent, are currently licensed for use. As part of the National Health Mission, the Government of India launched for the year 2016 for the first time, a population-based prevention, screening, and control program for cervical cancer. The World Health Organization has launched a cervical cancer elimination initiative that looks forward to a cancer-free future. The review concludes that though there are challenges at every level, the solution points in only one direction. All need to work together to ensure the HPV vaccination program is included in our National Immunization Program as the top priority. 

References

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin.2021;71(3):209-49. doi: 10.3322/caac.21660, PMID 33538338.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo Met al.Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN2012. IntJ Cancer. 2015Mar1;136(5):E359-86. doi: 10.1002/ijc.29210, PMID 25220842.

Sreedevi A, Javed R, Dinesh A. Epidemiology of cervical cancer with special focus on India. Int J Womens Health. 2015Apr16;7:405-14. doi: 10.2147/IJWH.S50001, PMID 25931830, PMCID PMC4404964.

Nigam A, Saxena P, Acharya AS, Mishra A, Batra S. HPV vaccination in India: critical appraisal. ISRN Obstet Gynecol. 2014;2014:394595. doi: 10.1155/2014/394595, PMID 25006481.

Schiffman M, Castle PE. The promise of global cervical-cancer prevention. NEnglJ Med. 2005Nov17;353(20):2101-4. doi: 10.1056/NEJMp058171, PMID 16291978.

Lei J, Ploner A, Elfström KM, Wang J, Roth A, Fang F, et al. HPV vaccination and the risk of invasive cervical cancer. NEnglJ Med.2020;383(14):1340-8. doi: 10.1056/NEJMoa1917338, PMID 32997908.

Mix JM, Van Dyne EA, Saraiya M, Hallowell BD, Thomas CC. Assessing impact of HPV vaccination on cervical cancer incidence among women aged 15-29 years in the United States, 1999-2017: an ecologic study. Cancer Epidemiol Biomarkers Prev. 2021Jan1;30(1):30-7. doi: 10.1158/1055-9965.EPI-20-0846, PMID 33082207.

Temte JL. HPV vaccine: a cornerstone of female health. AmFamPhysician. 2007Jan1;75(1):28. PMID 17225700.

Senkomago V, Henley SJ, Thomas CC, Mix JM, Markowitz LE, Saraiya M. Human papillomavirus-attributable cancers - United States, 2012-2016. MMWRMorb MortalWklyRep.2019;68(33):724-8. doi: 10.15585/mmwr.mm6833a3, PMID 31437140.

Kasi SG, Shivananda S, Marathe S, Chatterjee K, Agarwalla S, Dhir SKet al.Indian Academy of Pediatrics (IAP) Advisory Committee on Vaccines and Immunization Practices (ACVIP): Recommended immunizationschedule (2020-21) and update on immunization for childrenaged 0 through 18 years. Indian Pediatr.2021;58(1):44-53. doi: 10.1007/s13312-021-2096-7, PMID 33257602.

Sankaranarayanan R, Basu P, Kaur P, Bhaskar R, Singh GB, Denzongpa Pet al.Current status of human papillomavirus vaccination in India’s cervical cancer prevention efforts. Lancet Oncol. 2019Nov1;20(11):e637-44. doi: 10.1016/S1470-2045(19)30531-5, PMID 31674322.

Chatterjee A. The next generation of HPVvaccines: nonavalent vaccine V503 on the horizon. Expert Rev Vaccines.2014;13(11):1279-90. doi: 10.1586/14760584.2014.963561, PMID 25256262.

Dehlendorff C, Baandrup L, Kjaer SK. Real-world effectiveness of human papillomavirus vaccination against vulvovaginal high-grade precancerous lesions and cancers. J Natl Cancer Inst. 2021Jul;113(7):869-74. doi: 10.1093/jnci/djaa209, PMID 33377930.

Kaarthigeyan K. Cervical cancer in India and HPV vaccination. Indian J Med PaediatrOncol. 2012Jan;33(1):7-12. doi: 10.4103/0971-5851.96961, PMID 22754202.

KombeKombe AJ, Li B, Zahid A, Mengist HM, Bounda GA, Zhou Yet al.Epidemiology and burden of human papillomavirus and related diseases, molecular pathogenesis, and vaccine evaluation. Front Public Health. 2020;8:1003. doi: 10.3389/fpubh.2020.552028, PMID 33553082.

Kasi SG, Shivananda S, Marathe S, Chatterjee K, Agarwalla S, Dhir SKet al.Indian Academy of Pediatrics (IAP) Advisory Committee on Vaccines and Immunization Practices (ACVIP): Recommended immunizationschedule (2020-21) and update on immunization for childrenaged 0 through 18 years. Indian Pediatr.2021;58(1):44-53. doi: 10.1007/s13312-021-2096-7, PMID 33257602.

Kasi SG, Shivananda S, Marathe S, Chatterjee K, Agarwalla S, Dhir SKet al.Indian Academy of Pediatrics (IAP)Advisory Committee on vaccines and immunization practices (ACVIP): recommended immunization schedule (2020-21) and update on immunization for children aged 0 through 18 years. Indian Pediatr. 2021Jan;58(1):44-53. doi: 10.1007/s13312-021-2096-7, PMID 33257602.

Human papillomavirus (HPV)vaccine [cited18.6.2022]. Available from: https://www.cancer.gov/about-cancer/causes-prevention/risk/infectious-agents/hpv-vaccine-fact-sheet.

WHO position papers on human papillomavirus (HPV). WklyEpidemiolRec.May2017.

Kamolratanakul S, Pitisuttithum P. Human papillomavirusvaccineefficacy and effectiveness against cancer. Vaccines. 2021Dec;9(12):1413. doi: 10.3390/vaccines9121413, PMID 34960159.

Bharadwaj M, Hussain S, Nasare V, Das BC. HPV&HPV vaccination: issues in developing countries. Indian J MedRes. 2009;130(3):327-33. PMID 19901442.

Thomas TL. The new human papillomavirus (HPV) vaccine: pros and cons for pediatric and adolescent health. PediatrNurs. 2008Sep1;34(5):429-31, PMID 19051848.

Guide to introducing HPV vaccine into National Immunization Programmes. Available from: http://apps.who.int/iris/bitstream/10665/253123/1/9789241549769-eng.pdf(accessed[accessed on18.6.2022].

Global cancerdata: GLOBOCAN2018. Available from: https://www.uicc.org/news/global-cancer-data-globocan-2018.

Cervical cancer- National Health Portal of India [cited6.4.2022]. Available from: https://www.nhp.gov.in/disease/reproductive-system/female-gynaecological-diseases-/cervical-cancer.

Cervical cancer [cited6.4.2022]. Available from: https://www.nhp.gov.in/disease/reproductive-system/female-gynaecological-diseases-/cervical-cancer.

Saxena U, Sauvaget C, Sankaranarayanan R. Evidence-based screening, early diagnosis and treatment strategy of cervical cancer for national policy in low-resource countries: example of India. Asian PacJ Cancer Prev. 2012;13(4):1699-703. doi: 10.7314/apjcp.2012.13.4.1699, PMID 22799391.

Ferlay J, Ervik M, Lam F, Colombet M, Mery L, Piñeros Met al.Global cancerobservatory: cancertoday. Lyon, France: International Agency for Research on Cancer; 2020 [cited[Jan 272021]]. Available from: https://gco.iarc.fr/today.

Tomljenovic L, Shaw CA. Human papillomavirus (HPV) vaccine policy and evidence-based medicine: are they at odds?Ann Med. 2013Mar1;45(2):182-93. doi: 10.3109/07853890.2011.645353, PMID 22188159.

Age-adjusted incidence rate of cervix uteri cancer among women in India between 2012 and 2016, by Population-Based Cancer Registries [cited18.6.2022]. Available from: https://www.statista.com/statistics/1244258/india-age-adjusted-incidence-rate-of-cervix-uteri-cancer-among-women-by-pbcr/.

Das D, Rai AK, Kataki AC, Barmon D, Deka P, Sharma JDet al.Nested multiplex PCR based detection of human papillomavirus in cervical carcinoma patients of North-EastIndia. Asian PacJ Cancer Prev. 2013;14(2):785-90. doi: 10.7314/apjcp.2013.14.2.785, PMID 23621238.

Srivastava S, Gupta S, Roy JK. High prevalence of oncogenic HPV-16 in cervical smears of asymptomatic females of eastern Uttar Pradesh, India: a population-based study. J Biosci. 2012;37(1):63-72. doi: 10.1007/s12038-012-9181-y, PMID 22357204.

Basu P, Roychowdhury S, Bafna UD, Chaudhury S, Kothari S, Sekhon Ret al.Human papillomavirus genotype distribution in cervical cancer in India: results from a multi-center study. Asian Pac J Cancer Prev.2009Jan1;10(1):27-34. PMID 19469620.

Franceschi S, Rajkumar R, Snijders PJ, Arslan A, Mahé C, Plummer M, et al.Papillomavirus infection in rural women in southern India. Br J Cancer. 2005;92(3):601-6. doi: 10.1038/sj.bjc.6602348, PMID 15668709.

Chatterjee S, Chattopadhyay A, Samanta L, Panigrahi P. HPV and cervical cancer epidemiology-current status of HPV vaccination in India. Asian PacJ Cancer Prev. 2016Aug1;17(8):3663-73. PMID 27644600.

FonthamETH, WolfAMD, Church TR, Etzioni R, Flowers CR, Herzig Aet al.Cervical cancer screening for individuals at average risk: 2020 guideline update from the American Cancer Society. CA CancerJ Clin. 2020Sep;70(5):321-46. doi: 10.3322/caac.21628, PMID 32729638.

Mishra R. An epidemiological study of cervical and breast screening in India: district-level analysis. BMC WomensHealth. 2020Dec;20(1):1-5.

Mehrotra R, Yadav K. Cervical Cancer: formulation and Implementation of Govt of India guidelines for screening and management. Indian J GynecolOncol. 2022Mar;20(1):4. doi: 10.1007/s40944-021-00602-z, PMID 34977333.

Cervical cancer elimination initiative-WHO [cited6.4.2022]. Available from: https://www.who.int/initiatives/cervical-cancer-elimination-initiative.

A cervical cancer-free future: first-ever global commitment to eliminate cancer [cited6.4.2022]. Available from: https://www.who.int/news/item/17-11-2020-a-cervical-cancer-free-future-first-ever-global-commitment-to-eliminate-a-cancer.

Published

2022-10-25

How to Cite

Ramesh, S. ., R, S., & S, S. (2022). Human Papillomavirus (Hpv) Vaccination of The Girl Child: An Intervention for Primary Prevention of Cervical Cancer in India: Life Sciences-Pediatrics. International Journal of Life Science and Pharma Research, 12(6), L165-L172. https://doi.org/10.22376/ijpbs/lpr.2022.12.6.L165-172

Issue

Section

Review Articles