Central Corneal Thickness Changes in Diabetic Retinopathy. A Prospective Observational and Correlative Study
Life Sciences-Corneal Thickness in Diabetic Retinopathy
DOI:
https://doi.org/10.22376/ijpbs/lpr.2022.12.6.SP25.L23-27Keywords:
Type 2 Diabetes Mellitus, Grades of Diabetic Retinopathy, Central Corneal Thickness, HbA1c, Ultrasound PachymetryAbstract
Generally, there is a delay of 4 to 7 years in the diagnosis of type 2 diabetes and about 20% of patients would have already developed some micro vascular complications at the time of diagnosis. To study the central corneal thickness (CCT) variation and correlate with grades of diabetic retinopathy in an adult South Indian population. The study was conducted on 184 eyes each of T2DM patients of duration more than 5 years. 98 males (53.26%) & 86 females (46.73%) were recruited. After recording age, sex and duration of diabetes, fundus examination was done. CCT measurements were determined using Ultrasonic Pachymetry. Diabetic retinopathy was classified based on ETDRS (Early diabetic retinopathy study) and mean CCT values of each group were correlated and statistically analysed using SPSS software Version 17. Out of 184 subjects recruited, 72 patients were with no diabetic retinopathy (NDR), 107 patients were with non-proliferative diabetic retinopathy (NPDR) and 5 patients were with proliferative diabetic retinopathy (PDR). The mean CCT of no diabetic retinopathy (NDR), non-proliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) were found to be 526.14μm, 533.98μm and 555.20μm respectively. CCT was found to be thicker for diabetics with proliferative diabetic retinopathy compared to those with no retinopathy; the difference was not statistically significant (p=0.16). Uncontrolled diabetics (HbA1c >7%) had thicker corneas compared with diabetics with good control which was statistically significant (p=0.003). CCT was higher in diabetics having duration > 10 years than with duration <10 years but was not statistically significant (p=0.117).
References
Wolfs RC, Klaver CC, Vingerling JR, Grobbee DE, Hofman A, de Jong PT. Distribution of central corneal thickness and its association with intraocular pressure: the Rotterdam Study. Am J Ophthalmol. 1997;123(6):767-72. doi: 10.1016/s0002-9394(14)71125-0, PMID 9535620.
Suchitra MR, Jaiganesh K, Parthasarathy S. Diabetic profile – screening of HbA1c – a random community assessment. J Clin Diagn Res. 2013;7(10):2200-2. doi: 10.7860/JCDR/2013/5690.3470, PMID 24298475.
Gros-Otero J, Arruabarrena-Sánchez C, Teus M. Central corneal thickness in a healthy Spanish population. Arch Soc Esp Oftamol. 2011;86(3):73–76:73-6. doi: 10.1016/j.oftal.2010.12.008, PMID .
Roszkowska AM, Tringali CG, Colosi P, Squeri CA, Ferreri G. Corneal endothelium evaluation in type I and type II diabetes mellitus. Ophthalmologica. 1999;213(4):258-61. doi: 10.1159/000027431, PMID 10420110.
Busted N, Olsen T, Schmitz O. Clinical observations on the corneal thickness and the corneal endothelium in diabetes mellitus. Br J Ophthalmol. 1981;65(10):687-90. doi: 10.1136/bjo.65.10.687, PMID 7317320.
Inoue K, Kato S, Inoue Y, Amano S, Oshika T. The corneal endothelium and thickness in ttype II diabetes mellitus. Jpn J Ophthalmol. 2002;46(1):65-9. doi: 10.1016/s0021-5155(01)00458-0, PMID 11853716.
Schultz RO, Matsuda M, Yee RW, Edelhauser HF, Schultz KJ. Corneal endothelial changes in type I and type II diabetes mellitus. Am J Ophthalmol. 1984;98(4):401-10. doi: 10.1016/0002-9394(84)90120-x, PMID 6486211.
Keoleian GM, Pach JM, Hodge DO, Trocme SD, Bourne WM. Structural and functional studies of the corneal endothelium in diabetes mellitus. Am J Ophthalmol. 1992;113(1):64-70. doi: 10.1016/s0002-9394(14)75755-1, PMID 1728148.
Choo MM, Prakash K, Samsudin A, Soong T, Ramli N, Kadir AJ. Corneal changes in type II diabetes mellitus in Malaysia. Int J Ophthalmol. 2010;3(3):234-6. Doi: 18, doi: 10.3980/j.issn.2222-3959.2010.03.12, PMID 22553561.
Brandt JD, Beiser JA, Kass MA, Gordon MO. Central corneal thickness in the Ocular Hypertension Treatment Study (OHTS). Ophthalmology. 2001;108(10):1779-88. doi: 10.1016/s0161-6420(01)00760-6, PMID 11581049.
Mathebula SD, Segoati TM. Is the central corneal thickness of diabetic patients thicker than that of non- diabetics’ eyes? Afr Vis Eye Health. 2015;74(1): 5 pages. doi: 10.4102/aveh.v74i1.307.
Eysteinsson T, Jonasson F, Sasaki H, Arnarsson A, Sverrisson T, Sasaki K, et al. Central corneal thickness, radius of the corneal curvature and intraocular pressure in normal subjects using non-contact techniques: Reykjavik Eye Study. Acta Ophthalmol Scand. 2002;80(1):11-5. doi: 10.1034/j.1600-0420.2002.800103.x, PMID 11906297.
Nemesure B, Wu SY, Hennis A, Leske MC, Barbados Eye Study Group. Corneal thickness and intraocular pressure in the Bar-bados Eye Studies. Arch Ophthalmol. 2003;121(2):240-4. doi: 10.1001/archopht.121.2.240, PMID 12583791.
Aghaian E, Choe JE, Lin S, Stamper RL. Central corneal thickness of Caucasians, Chinese, Hispanics, Filipinos, African Americans, and Japanese in a glaucoma clinic, Chinese. Ophthalmology. 2004;111(12):2211-9. doi: 10.1016/j.ophtha.2004.06.013, PMID 15582076.
Ozdamar Y, Cankaya B, Ozalp S, Acaroglu G, Karakaya J, Ozkan SS. Is there a correlation between diabetes mellitus and central corneal thickness? J Glaucoma. 2010;19(9):613-6. doi: 10.1097/IJG.0b013e3181ca7c62, PMID 20051882.
Vijaya L, George R, Baskaran M, Arvind H, Raju P, Ramesh SV, et al. Prevalence of primary open-angle glaucoma in an urban south Indian population and comparison with a rural population. Ophthalmology. 2008;115(4):648-654.e1. doi: 10.1016/j.ophtha.2007.04.062.
Roszkowska AM, Tringali CG, Colosi P, Squeri CA, Ferreri G. Corneal endothelium evaluation in type I and type II diabetes mellitus. Ophthalmologica. 1999;213(4):258-61. doi: 10.1159/000027431, PMID 10420110.
Lee JS, Oum BS, Choi HY, Lee JE, Cho BM. Differences in corneal thickness and corneal endothelium related to duration in diabetes. Eye. 2006: 913754;20:315-8.Beata Urban et al Evaluation of Corneal Endothelium in Children and Adolescents with Type 1 Diabetes Mellitus Mediators Inflamm. 2013. doi: 10.1155/2013/913754.
Briggs S, Osuagwu UL, AlHarthi EMStella Briggs et al. Manifestations of type 2 diabetes in corneal endothelial cell density, corneal thickness and intraocular pressure. J Biomed Res. 2015;30(1):46-51. doi: 10.7555/JBR.29.20140075, PMID 26616588.
Makkar B, Srivastav T, Mishra D, Singh MK. Changes in the Central Corneal Thickness in Diabetes Mellitus Patients with age and Gender Matched Healthy Controls in North Indian Population. Ann. Int. Med. Den. Res. 2018;4(4):OT07-OT09. doi: 10.21276/aimdr.2018.4.4.OT2.
Weston BC, Bourne WM, Polse KA, Hodge DO. Corneal hydration control in diabetes mellitus. Invest Ophthalmol Vis Sci. 1995;36(3):586-95. PMID 7890490.
Su DH, Wong TY, Wong WL, Saw SM, Tan DT, Shen SY, et al. Diabetes, hyperglycemia, and central corneal thickness: the Singapore Malay Eye Study. Ophthalmology. 2008;115(6):964-968.e1. doi: 10.1016/j.ophtha.2007.08.021, PMID 17964654.
Ozdamar Y, Cankaya B, Ozalp S, Acaroglu G, Karakaya J, Ozkan SS. Is there a correlation between diabetes mellitus and central corneal thickness? J Glaucoma. 2010;19(9):613-6. doi: 10.1097/IJG.0b013e3181ca7c62, PMID 20051882.
Choo MM, Prakash K, Samsudin A, Soong T, Ramli N, Kadir AJ. Corneal changes in type II diabetes mellitus in Malaysia. Int J Ophthalmol. 2010;3(3):234-6. Doi: 18, doi: 10.3980/j.issn.2222-3959.2010.03.12, PMID 22553561.
Okan T et al. Central corneal thickness in type II diabetes mellitus: is it related to the severity of diabetic retinopathy? Turk J Med Sci. 2015;45:651-654doi:10.3906/sag-1404-153.
Mathebula SD, Segoati TM. Is the central corneal thickness of diabetic patients thicker than that of non- diabetics’ eyes? Afr Vis Eye Health. 2015;74(1): 5 pages. doi: 10.4102/aveh.v74i1.307.
Siribunkum J, Kosrirukvongs P, Singalavanija A. Corneal abnormalities in diabetes. J Med Assoc Thai. 2001;84(8):1075-83. PMID 11758839.
Wiemer NG, Dubbelman M, Kostense PJ, Ringens PJ, Polak BC. The influence of chronic diabetes mellitus on the thickness and the shape of the anterior and posterior surface of the cornea. Cornea. 2007 Dec;26(10):1165-70. doi: 10.1097/ICO.0b013e31814fa82f, PMID 18043169.
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