In Vitro Anti-Cancer Activity of Schiff Base 2,4-Dichloro-6-(P-Tolylimino-Methyl)-Phenol and Its Transition metal complexes.

Pharmaceutical Science-Chemistry for New drug discovery

Abstract

Cancer is the world's second-biggest cause of mortality, accounting for 9.6 million deaths in 2018, and the burden continues to rise. As a result, better newer medications with greater efficacy for the treatment of various tumours are clearly and urgently needed. Anticancer drugs have been grouped as chemotherapy, hormonal remedy and immunotherapy. Chemotherapy protected various categories of drugs, each defined by its chemical structure and mode of action, such as alkylating agents, antibiotics, antimetabolites, mitotic inhibitors, and others. Although this issue has been widely explored, Schiff bases, which are formed from the condensation reaction of aromatic/aliphatic aldehydes and amines and form stable complexes with various transition metal ions, are still of significant interest in inorganic chemistry. Schiff bases and their metal complexes are promising leads for both synthetic and structural research due to their relatively simple synthesis and structural diversity and have been widely investigated, due to their incredible chemical properties and applications in various areas. The chelating ability and biological applications of metal complexes have attracted remarkable attention and they can work as models for biologically important species. Schiff bases and their complexes are flexible compounds synthesized from the condensation of an amino compound with carbonyl compounds and extensively used for industrial purposes and also show a broad range of biological activities including antibacterial, antifungal, antiviral, antimalarial, antiproliferative, anti-inflammatory, anticancer, anti-HIV, anthelmintic and antipyretic properties. The purpose of this research work was to assess the in vitro anticancer activity of the synthesized Schiff base molecule and its transition metal complexes against Human breast carcinoma Cancer cells at various doses (1000, 300, 100, 30, 10, and 3 g/ml). The anticancer activity of the free ligand and its metal complexes showed good to high activity against human breast cancer cells. Schiff base and its transition metal complexes against human breast cancer cell lines fascinate the researchers to develop new anticancer drugs without side effects.