SEARCH FOR PROTEIN EBNA-1 P79 ANTI EBV IN SERUM OF PATIENTS REACHES ANY OF BREAST CANCER AND FROM WESTERN ALGERIA

Life Sciences-Biology

Abstract

Breast cancer is in most countries, the most common cancer in women. It is the leading cause of death worldwide, there is a multifactorial disease where multiple events can be the cause of this disease, it is noted as an example genetic factors such asBRCA1 and BRCA2 genes and here ditary environmental factors, the notion of cancer virusis back in for cein the field of scientific research since the virus-induced cancers increasingly studied. Several families of viruses can induce cancer as the Epstein-Barr virus (EBV).The aim of the present study was to determine if there is a greater association of EBV infection with breast cancer patients as compared patients with nasopharyngeal cancer.We measured the levels ofanti-EBNA-1 P 79 in serum of these patients stored using Western blot technique. Patients with nasopharyngeal cancer were used as control group for comparison to serological analysis.Our study included 24 patients with breast cancer and  6  patients  with  nasopharyngeal  cancer  in  western  Algeria,  from  January  2009  to  June  2009  in gynecology (CHUO), at the Pasteur Institute of Sidiférruj and Biology Laboratory of Development and Differentiation. 19 of 24 sera (79.16%) showed a positive serological profile, the 6 sera of patients reaches any of nasopharyngeal cancer (100%) were positive.The expression of EBNA-1P79 is seen in a significant proportion  of  sera  from  breast  cancer,  also  for  patients  with  nasopharyngeal  cancer.  Our  results  are consistent with those found in the literature.