Plantarhyperhidrosis: The Efficacy Of Iontophoresis With Tap Water, Glycopyrronium Bromide And Indomethacin

Life Sciences-Physiotherapy for better pain management

Abstract

Hyperhidrosis is  an excessive production of sweat  more  than  the  physiological  amount  necessary  to  maintain thermal homeostasis. Primary focal  hyperhidrosis  is a disorder of  unknown etiology,  causing excessive,  bilateral,  symmetrical  sweating  on the soles  of  the foot is called plantar hyperhidrosis. The condition results not only in physical impairment, but also interferes with professional and social life. Although not life- threatening, it is  very uncomfortable and cause embarrassment  and psychological trauma. Iontophoresis is a helpful method,  which includes the presentation of particles into the body tissue through the skin. The essential principle is to place the ion particles under an electrode with the same charge, i.e. negative  ion  placed  under  cathode  and positive  ion  placed under  anode.  This  complete  process  is  also  known as “technique  of  ion transfer” into the body tissues by using electrical current  as a driving force.  It is a comparative study with pre and post intervention. 30 subjects with plantar hyperhidrosis were selected based on the inclusion criteria. The study duration was for about 4 weeks30 subjects of age group between 15 –25 years with idiopathic plantar hyperhidrosis of both  male and female subjects were  included in this study. Subjects with cardiac and respiratory disorders, pregnant or lactating, any cuts, abrasions, eczema or infections on plantar aspect, metal implants like pacemakers, Hypersensitivity to the active substance were excluded. The subjects were divided into 3 group Group A treated  with iontophoresis using tap water alone. Group B were treated  with iontophoresis using tap water along with 3%-5% of anticholinergic drug, glycopyrronium bromide solution. Group C were treated  with iontophoresis using tap water along with 1% of indomethacin (NSAID). The result of this study shows that there  were significant changes in outcome measures. On comparing Mean values of Group A, Group B & Group C on Minor test (Starch - Iodine Test) tap Water  along with Glycopyrronium Bromide (Group B) shows 1.60 which has the Lower Mean value is effective than Group A and Group C .On comparing Mean values of Group A, Group B & Group C on Visual Analog Scale score tap Water  along with Glycopyrronium Bromide (Group B) shows 3.80 which has the Lower Mean value is effective than Group A and Group C. On comparing Mean values of Group A, Group B & Group C on Hyperhidrosis Disease Severity Scale tap Water  along with Glycopyrronium Bromide (Group B) shows 1.40 which has the Lower Mean value is effective than Group A and Group C.  On comparing all the three groups, Group B shows better  result than Group C and Group A in outcome measure. This study concluded that Tap water along with glycopyrronium bromide reduces the excessive sweating and decrease the sweating symptoms in subjects with plantar hyperhidrosis.